Ophthalmic complications following treatment of paranasal sinus rhabdomyosarcoma in comparison to orbital disease

Parag D. Gandhi, James Fleming, Barrett G. Haik, Matthew Wilson

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

PURPOSE:: To identify the type and frequency of ocular and orbital complications observed following treatment for primary rhabdomyosarcoma of the paranasal sinuses or the orbit. METHODS:: An institutional review board-approved, Health Insurance Portability and Accountability Act-compliant retrospective chart review was conducted to identify all patients treated at one institution from 1966 to 2005 with biopsy-proven primary paranasal sinus or orbital rhabdomyosarcoma. Pretreatment, treatment, and follow-up data were collected. RESULTS:: Forty-four patients (25 male) of a median age of 7.8 years (range 1.0-18.0 years) with primary paranasal sinus (17) or orbital (27) rhabdomyosarcoma were treated and followed for a median period of 5.3 years (range 0.6-32.0 years). The three most frequently observed ophthalmic complications were persistent eyelid erythema or cellulitis (12), epithelial keratitis (7), and conjunctival injection (6) in the paranasal sinus and epithelial keratitis (18), conjunctival injection (11), and cataract (10) in the orbit. Overall survival after treatment trended higher for the orbital rhabdomyosarcoma group (23 of 27) than the paranasal sinus group (9 of 17). CONCLUSIONS:: The most frequently observed treatment-induced ophthalmic complications in the paranasal sinus group were manageable with minimal patient morbidity, as in the patients with orbital disease. Vision-threatening complications were infrequently encountered. Despite maximal therapy, the mortality rate was higher in the paranasal sinus rhabdomyosarcoma group than in the orbital rhabdomyosarcoma group.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalOphthalmic Plastic and Reconstructive Surgery
Volume27
Issue number4
DOIs
StatePublished - Jul 1 2011

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Orbital Diseases
Rhabdomyosarcoma
Paranasal Sinuses
Keratitis
Orbit
Therapeutics
Health Insurance Portability and Accountability Act
Injections
Cellulitis
Research Ethics Committees
Eyelids
Erythema
Cataract
Morbidity
Biopsy
Survival
Mortality

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Surgery

Cite this

Ophthalmic complications following treatment of paranasal sinus rhabdomyosarcoma in comparison to orbital disease. / Gandhi, Parag D.; Fleming, James; Haik, Barrett G.; Wilson, Matthew.

In: Ophthalmic Plastic and Reconstructive Surgery, Vol. 27, No. 4, 01.07.2011, p. 241-246.

Research output: Contribution to journalReview article

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