Opioid inhibition of rapid eye movement sleep by a specific mu receptor agonist

A. Cronin, J. C. Keifer, Helen Baghdoyan, Ralph Lydic

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Patients receiving opioids report feeling sleepy, but opioids actually inhibit the rapid eye movement phase of sleep (REM). Inhibition of REM sleep is followed by a rebound increase in REM sleep associated with cardiopulmonary complications. The medial pontine reticular formation (mPRF) is a brain region from which morphine can inhibit REM sleep. The present study tested the hypothesis that specific subtypes of opioid receptors within the mPRF mediate inhibition of REM sleep. Synthetic opioid agonists selective for mu, delta and kappa subtypes were microinjected into the mPRF of four awake cats and polygraphic recordings of sleep and breathing were obtained. An enkephalinase inhibitor was microinjected into the mPRF to assess the contribution of endogenous opioids to the control of sleep and breathing. Only the mu agonist significantly inhibited REM sleep, and no opioid depressed breathing. These results demonstrate that opioid-induced REM sleep inhibition is mediated by mu receptor subtypes in the mPRF.

Original languageEnglish (US)
Pages (from-to)188-192
Number of pages5
JournalBritish Journal of Anaesthesia
Volume74
Issue number2
DOIs
StatePublished - Jan 1 1995

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mu Opioid Receptor
REM Sleep
Opioid Analgesics
Sleep
Respiration
Neprilysin
Inhibition (Psychology)
Opioid Receptors
Morphine
Emotions
Cats
Pontine Tegmentum
Brain

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Opioid inhibition of rapid eye movement sleep by a specific mu receptor agonist. / Cronin, A.; Keifer, J. C.; Baghdoyan, Helen; Lydic, Ralph.

In: British Journal of Anaesthesia, Vol. 74, No. 2, 01.01.1995, p. 188-192.

Research output: Contribution to journalArticle

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