Opioid receptors and endogenous opioids in diverse human and animal cancers

I. S. Zagon, P. J. McLaughlin, S. R. Goodman, R. E. Rhodes

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Receptor binding studies demonstrated specific high-affinity, saturable binding of a number of opioid ligands to a wide variety of neural and nonneural human and animal tumors. Radioimmunoassays revealed the presence of β-endorphin and methionine-enkephalin in these tumors. Both methionine- and leucine-enkephalin were detected in tumor tissue by immunocytochemistry, with immunoreactivity related to the cortical cytoplasm of tumor cells, but not to cell nuclei. Endogenous opioids and receptors were found in benign and malignant tumors representative of ectodermal, mesodermal, and endodermal origin. Receptors and endogenous opioid peptides were present in tumors from many different species, including those transplanted into nude mice. These results suggest that opioid receptors and endogenous opioids are fundamental features of human and animal cancers.

Original languageEnglish (US)
Pages (from-to)1059-1065
Number of pages7
JournalJournal of the National Cancer Institute
Volume79
Issue number5
StatePublished - Dec 1 1987

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Opioid Receptors
Opioid Analgesics
Neoplasms
Methionine Enkephalin
Endorphins
Leucine Enkephalin
Opioid Peptides
Cell Nucleus
Nude Mice
Radioimmunoassay
Cytoplasm
Immunohistochemistry
Ligands

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Opioid receptors and endogenous opioids in diverse human and animal cancers. / Zagon, I. S.; McLaughlin, P. J.; Goodman, S. R.; Rhodes, R. E.

In: Journal of the National Cancer Institute, Vol. 79, No. 5, 01.12.1987, p. 1059-1065.

Research output: Contribution to journalArticle

Zagon, I. S. ; McLaughlin, P. J. ; Goodman, S. R. ; Rhodes, R. E. / Opioid receptors and endogenous opioids in diverse human and animal cancers. In: Journal of the National Cancer Institute. 1987 ; Vol. 79, No. 5. pp. 1059-1065.
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