Opportunities and challenges facing biomarker development for personalized head and neck cancer treatment

Alexandra V. Lucs, Benjamin Saltman, Christine H. Chung, Bettie M. Steinberg, David Schwartz

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Head and neck oncologists have traditionally relied on clinical tumor features and patient characteristics to guide care of individual patients. As surgical, radiotherapeutic, and systemic treatments have evolved to become more anatomically precise and mechanistically specific, the opportunity for improved cure and functional patient recovery has never been more promising for this historically debilitating cancer. However, personalized treatment must be accompanied by sophisticated patient selection to triage the application of advanced therapies toward ideal patient candidates. In this monograph, we review current progress, investigative themes, and key challenges facing head and neck cancer biomarker development intended to make personalized head and neck cancer treatment a clinical reality.

Original languageEnglish (US)
Pages (from-to)294-306
Number of pages13
JournalHead and Neck
Volume35
Issue number2
DOIs
StatePublished - Feb 1 2013

Fingerprint

Head and Neck Neoplasms
Biomarkers
Triage
Therapeutics
Tumor Biomarkers
Patient Selection
Neoplasms
Patient Care
Neck
Head

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Opportunities and challenges facing biomarker development for personalized head and neck cancer treatment. / Lucs, Alexandra V.; Saltman, Benjamin; Chung, Christine H.; Steinberg, Bettie M.; Schwartz, David.

In: Head and Neck, Vol. 35, No. 2, 01.02.2013, p. 294-306.

Research output: Contribution to journalReview article

Lucs, Alexandra V. ; Saltman, Benjamin ; Chung, Christine H. ; Steinberg, Bettie M. ; Schwartz, David. / Opportunities and challenges facing biomarker development for personalized head and neck cancer treatment. In: Head and Neck. 2013 ; Vol. 35, No. 2. pp. 294-306.
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