Opposing changes in osteocalcin levels in bone vs serum during the acquisition of peak bone density in C3H/HeJ and C57BL/6J mice

X. Li, A. K. Srivastava, Weikuan Gu, G. Masinde, S. Mohan, D. J. Baylink

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Our knowledge of the developmental changes in the concentration of serum and bone osteocalcin (OC) is limited. To investigate the interrelationship between skeletal and circulatory OC during acquisition of peak bone density in mice, we examined the temporal changes in the concentration of serum and bone OC from 3 to 12 weeks of age between C3H/HeJ (C3H) and C57BL/6J (B6), two commonly used inbred strains of mice with a large difference in bone density. We have demonstrated an increase in bone and decrease in serum OC during the acquisition of peak bone density in C3H and B6 mice which parallels an increase in bone mineral density. These two strains exhibited differential changes in the concentration of OC. C3H mice retained more OC in bone and secreted less into serum compared with B6, which coincides with the large differences in bone density between these two strains. These opposite changes of OC levels in bone and serum between C3H and B6 stress the importance of defining the genetic mechanisms underlying the differences in OC metabolism, differences that could be relevant to the acquisition and maintenance of bone mass in mice.

Original languageEnglish (US)
Pages (from-to)416-420
Number of pages5
JournalCalcified Tissue International
Volume71
Issue number5
DOIs
StatePublished - Nov 1 2002
Externally publishedYes

Fingerprint

Osteocalcin
Inbred C57BL Mouse
Bone Density
Bone and Bones
Serum
Inbred C3H Mouse
Inbred Strains Mice
Maintenance

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

Opposing changes in osteocalcin levels in bone vs serum during the acquisition of peak bone density in C3H/HeJ and C57BL/6J mice. / Li, X.; Srivastava, A. K.; Gu, Weikuan; Masinde, G.; Mohan, S.; Baylink, D. J.

In: Calcified Tissue International, Vol. 71, No. 5, 01.11.2002, p. 416-420.

Research output: Contribution to journalArticle

Li, X. ; Srivastava, A. K. ; Gu, Weikuan ; Masinde, G. ; Mohan, S. ; Baylink, D. J. / Opposing changes in osteocalcin levels in bone vs serum during the acquisition of peak bone density in C3H/HeJ and C57BL/6J mice. In: Calcified Tissue International. 2002 ; Vol. 71, No. 5. pp. 416-420.
@article{0290d678229549c7b3d75d179f1385f4,
title = "Opposing changes in osteocalcin levels in bone vs serum during the acquisition of peak bone density in C3H/HeJ and C57BL/6J mice",
abstract = "Our knowledge of the developmental changes in the concentration of serum and bone osteocalcin (OC) is limited. To investigate the interrelationship between skeletal and circulatory OC during acquisition of peak bone density in mice, we examined the temporal changes in the concentration of serum and bone OC from 3 to 12 weeks of age between C3H/HeJ (C3H) and C57BL/6J (B6), two commonly used inbred strains of mice with a large difference in bone density. We have demonstrated an increase in bone and decrease in serum OC during the acquisition of peak bone density in C3H and B6 mice which parallels an increase in bone mineral density. These two strains exhibited differential changes in the concentration of OC. C3H mice retained more OC in bone and secreted less into serum compared with B6, which coincides with the large differences in bone density between these two strains. These opposite changes of OC levels in bone and serum between C3H and B6 stress the importance of defining the genetic mechanisms underlying the differences in OC metabolism, differences that could be relevant to the acquisition and maintenance of bone mass in mice.",
author = "X. Li and Srivastava, {A. K.} and Weikuan Gu and G. Masinde and S. Mohan and Baylink, {D. J.}",
year = "2002",
month = "11",
day = "1",
doi = "10.1007/s00223-001-1106-y",
language = "English (US)",
volume = "71",
pages = "416--420",
journal = "Calcified Tissue International",
issn = "0171-967X",
publisher = "Springer New York",
number = "5",

}

TY - JOUR

T1 - Opposing changes in osteocalcin levels in bone vs serum during the acquisition of peak bone density in C3H/HeJ and C57BL/6J mice

AU - Li, X.

AU - Srivastava, A. K.

AU - Gu, Weikuan

AU - Masinde, G.

AU - Mohan, S.

AU - Baylink, D. J.

PY - 2002/11/1

Y1 - 2002/11/1

N2 - Our knowledge of the developmental changes in the concentration of serum and bone osteocalcin (OC) is limited. To investigate the interrelationship between skeletal and circulatory OC during acquisition of peak bone density in mice, we examined the temporal changes in the concentration of serum and bone OC from 3 to 12 weeks of age between C3H/HeJ (C3H) and C57BL/6J (B6), two commonly used inbred strains of mice with a large difference in bone density. We have demonstrated an increase in bone and decrease in serum OC during the acquisition of peak bone density in C3H and B6 mice which parallels an increase in bone mineral density. These two strains exhibited differential changes in the concentration of OC. C3H mice retained more OC in bone and secreted less into serum compared with B6, which coincides with the large differences in bone density between these two strains. These opposite changes of OC levels in bone and serum between C3H and B6 stress the importance of defining the genetic mechanisms underlying the differences in OC metabolism, differences that could be relevant to the acquisition and maintenance of bone mass in mice.

AB - Our knowledge of the developmental changes in the concentration of serum and bone osteocalcin (OC) is limited. To investigate the interrelationship between skeletal and circulatory OC during acquisition of peak bone density in mice, we examined the temporal changes in the concentration of serum and bone OC from 3 to 12 weeks of age between C3H/HeJ (C3H) and C57BL/6J (B6), two commonly used inbred strains of mice with a large difference in bone density. We have demonstrated an increase in bone and decrease in serum OC during the acquisition of peak bone density in C3H and B6 mice which parallels an increase in bone mineral density. These two strains exhibited differential changes in the concentration of OC. C3H mice retained more OC in bone and secreted less into serum compared with B6, which coincides with the large differences in bone density between these two strains. These opposite changes of OC levels in bone and serum between C3H and B6 stress the importance of defining the genetic mechanisms underlying the differences in OC metabolism, differences that could be relevant to the acquisition and maintenance of bone mass in mice.

UR - http://www.scopus.com/inward/record.url?scp=0042164734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042164734&partnerID=8YFLogxK

U2 - 10.1007/s00223-001-1106-y

DO - 10.1007/s00223-001-1106-y

M3 - Article

C2 - 12172650

AN - SCOPUS:0042164734

VL - 71

SP - 416

EP - 420

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 0171-967X

IS - 5

ER -