Optical coherence tomography angiography vessel density in healthy, glaucoma suspect, and glaucoma eyes

Adeleh Yarmohammadi, Linda M. Zangwill, Alberto Diniz-Filho, Min Hee Suh, Patricia Isabel Manalastas, Naeem Fatehee, Siamak Yousefi, Akram Belghith, Luke J. Saunders, Felipe A. Medeiros, David Huang, Robert N. Weinreb

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Abstract

PURPOSE. The purpose of this study was to compare retinal nerve fiber layer (RNFL) thickness and optical coherence tomography angiography (OCT-A) retinal vasculature measurements in healthy, glaucoma suspect, and glaucoma patients. METHODS. Two hundred sixty-one eyes of 164 healthy, glaucoma suspect, and open-angle glaucoma (OAG) participants from the Diagnostic Innovations in Glaucoma Study with good quality OCT-A imageswere included. Retinal vasculature informationwas summarized as a vessel density map and as vessel density (%), which is the proportion of flowing vessel area over the total area evaluated. Two vessel density measurements extracted from the RNFL were analyzed: (1) circumpapillary vessel density (cpVD) measured in a 750-μm-wide elliptical annulus around the disc and (2) whole image vessel density (wiVD) measured over the entire image. Areas under the receiver operating characteristic curves (AUROC) were used to evaluate diagnostic accuracy. RESULTS. Age-adjusted mean vessel density was significantly lower in OAG eyes compared with glaucoma suspects and healthy eyes. (cpVD: 55.1 ± 7%, 60.3 ± 5%, and 64.2 ± 3%, respectively; P < 0.001; and wiVD: 46.2 ± 6%, 51.3 ± 5%, and 56.6 ± 3%, respectively; P < 0.001). For differentiating between glaucoma and healthy eyes, the age-adjusted AUROC was highest for wiVD (0.94), followed by RNFL thickness (0.92) and cpVD (0.83). The AUROCs for differentiating between healthy and glaucoma suspect eyes were highest for wiVD (0.70), followed by cpVD (0.65) and RNFL thickness (0.65). CONCLUSIONS. Optical coherence tomography angiography vessel density had similar diagnostic accuracy to RNFL thickness measurements for differentiating between healthy and glaucoma eyes. These results suggest that OCT-A measurements reflect damage to tissues relevant to the pathophysiology of OAG.

Original languageEnglish (US)
Pages (from-to)OCT451-OCT459
JournalInvestigative Ophthalmology and Visual Science
Volume57
Issue number9
DOIs
StatePublished - Jan 1 2016

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Ocular Hypertension
Optical Coherence Tomography
Glaucoma
Angiography
Nerve Fibers
Open Angle Glaucoma
ROC Curve

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Yarmohammadi, A., Zangwill, L. M., Diniz-Filho, A., Suh, M. H., Manalastas, P. I., Fatehee, N., ... Weinreb, R. N. (2016). Optical coherence tomography angiography vessel density in healthy, glaucoma suspect, and glaucoma eyes. Investigative Ophthalmology and Visual Science, 57(9), OCT451-OCT459. https://doi.org/10.1167/iovs.15-18944

Optical coherence tomography angiography vessel density in healthy, glaucoma suspect, and glaucoma eyes. / Yarmohammadi, Adeleh; Zangwill, Linda M.; Diniz-Filho, Alberto; Suh, Min Hee; Manalastas, Patricia Isabel; Fatehee, Naeem; Yousefi, Siamak; Belghith, Akram; Saunders, Luke J.; Medeiros, Felipe A.; Huang, David; Weinreb, Robert N.

In: Investigative Ophthalmology and Visual Science, Vol. 57, No. 9, 01.01.2016, p. OCT451-OCT459.

Research output: Contribution to journalArticle

Yarmohammadi, A, Zangwill, LM, Diniz-Filho, A, Suh, MH, Manalastas, PI, Fatehee, N, Yousefi, S, Belghith, A, Saunders, LJ, Medeiros, FA, Huang, D & Weinreb, RN 2016, 'Optical coherence tomography angiography vessel density in healthy, glaucoma suspect, and glaucoma eyes', Investigative Ophthalmology and Visual Science, vol. 57, no. 9, pp. OCT451-OCT459. https://doi.org/10.1167/iovs.15-18944
Yarmohammadi, Adeleh ; Zangwill, Linda M. ; Diniz-Filho, Alberto ; Suh, Min Hee ; Manalastas, Patricia Isabel ; Fatehee, Naeem ; Yousefi, Siamak ; Belghith, Akram ; Saunders, Luke J. ; Medeiros, Felipe A. ; Huang, David ; Weinreb, Robert N. / Optical coherence tomography angiography vessel density in healthy, glaucoma suspect, and glaucoma eyes. In: Investigative Ophthalmology and Visual Science. 2016 ; Vol. 57, No. 9. pp. OCT451-OCT459.
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abstract = "PURPOSE. The purpose of this study was to compare retinal nerve fiber layer (RNFL) thickness and optical coherence tomography angiography (OCT-A) retinal vasculature measurements in healthy, glaucoma suspect, and glaucoma patients. METHODS. Two hundred sixty-one eyes of 164 healthy, glaucoma suspect, and open-angle glaucoma (OAG) participants from the Diagnostic Innovations in Glaucoma Study with good quality OCT-A imageswere included. Retinal vasculature informationwas summarized as a vessel density map and as vessel density ({\%}), which is the proportion of flowing vessel area over the total area evaluated. Two vessel density measurements extracted from the RNFL were analyzed: (1) circumpapillary vessel density (cpVD) measured in a 750-μm-wide elliptical annulus around the disc and (2) whole image vessel density (wiVD) measured over the entire image. Areas under the receiver operating characteristic curves (AUROC) were used to evaluate diagnostic accuracy. RESULTS. Age-adjusted mean vessel density was significantly lower in OAG eyes compared with glaucoma suspects and healthy eyes. (cpVD: 55.1 ± 7{\%}, 60.3 ± 5{\%}, and 64.2 ± 3{\%}, respectively; P < 0.001; and wiVD: 46.2 ± 6{\%}, 51.3 ± 5{\%}, and 56.6 ± 3{\%}, respectively; P < 0.001). For differentiating between glaucoma and healthy eyes, the age-adjusted AUROC was highest for wiVD (0.94), followed by RNFL thickness (0.92) and cpVD (0.83). The AUROCs for differentiating between healthy and glaucoma suspect eyes were highest for wiVD (0.70), followed by cpVD (0.65) and RNFL thickness (0.65). CONCLUSIONS. Optical coherence tomography angiography vessel density had similar diagnostic accuracy to RNFL thickness measurements for differentiating between healthy and glaucoma eyes. These results suggest that OCT-A measurements reflect damage to tissues relevant to the pathophysiology of OAG.",
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AU - Zangwill, Linda M.

AU - Diniz-Filho, Alberto

AU - Suh, Min Hee

AU - Manalastas, Patricia Isabel

AU - Fatehee, Naeem

AU - Yousefi, Siamak

AU - Belghith, Akram

AU - Saunders, Luke J.

AU - Medeiros, Felipe A.

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AU - Weinreb, Robert N.

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N2 - PURPOSE. The purpose of this study was to compare retinal nerve fiber layer (RNFL) thickness and optical coherence tomography angiography (OCT-A) retinal vasculature measurements in healthy, glaucoma suspect, and glaucoma patients. METHODS. Two hundred sixty-one eyes of 164 healthy, glaucoma suspect, and open-angle glaucoma (OAG) participants from the Diagnostic Innovations in Glaucoma Study with good quality OCT-A imageswere included. Retinal vasculature informationwas summarized as a vessel density map and as vessel density (%), which is the proportion of flowing vessel area over the total area evaluated. Two vessel density measurements extracted from the RNFL were analyzed: (1) circumpapillary vessel density (cpVD) measured in a 750-μm-wide elliptical annulus around the disc and (2) whole image vessel density (wiVD) measured over the entire image. Areas under the receiver operating characteristic curves (AUROC) were used to evaluate diagnostic accuracy. RESULTS. Age-adjusted mean vessel density was significantly lower in OAG eyes compared with glaucoma suspects and healthy eyes. (cpVD: 55.1 ± 7%, 60.3 ± 5%, and 64.2 ± 3%, respectively; P < 0.001; and wiVD: 46.2 ± 6%, 51.3 ± 5%, and 56.6 ± 3%, respectively; P < 0.001). For differentiating between glaucoma and healthy eyes, the age-adjusted AUROC was highest for wiVD (0.94), followed by RNFL thickness (0.92) and cpVD (0.83). The AUROCs for differentiating between healthy and glaucoma suspect eyes were highest for wiVD (0.70), followed by cpVD (0.65) and RNFL thickness (0.65). CONCLUSIONS. Optical coherence tomography angiography vessel density had similar diagnostic accuracy to RNFL thickness measurements for differentiating between healthy and glaucoma eyes. These results suggest that OCT-A measurements reflect damage to tissues relevant to the pathophysiology of OAG.

AB - PURPOSE. The purpose of this study was to compare retinal nerve fiber layer (RNFL) thickness and optical coherence tomography angiography (OCT-A) retinal vasculature measurements in healthy, glaucoma suspect, and glaucoma patients. METHODS. Two hundred sixty-one eyes of 164 healthy, glaucoma suspect, and open-angle glaucoma (OAG) participants from the Diagnostic Innovations in Glaucoma Study with good quality OCT-A imageswere included. Retinal vasculature informationwas summarized as a vessel density map and as vessel density (%), which is the proportion of flowing vessel area over the total area evaluated. Two vessel density measurements extracted from the RNFL were analyzed: (1) circumpapillary vessel density (cpVD) measured in a 750-μm-wide elliptical annulus around the disc and (2) whole image vessel density (wiVD) measured over the entire image. Areas under the receiver operating characteristic curves (AUROC) were used to evaluate diagnostic accuracy. RESULTS. Age-adjusted mean vessel density was significantly lower in OAG eyes compared with glaucoma suspects and healthy eyes. (cpVD: 55.1 ± 7%, 60.3 ± 5%, and 64.2 ± 3%, respectively; P < 0.001; and wiVD: 46.2 ± 6%, 51.3 ± 5%, and 56.6 ± 3%, respectively; P < 0.001). For differentiating between glaucoma and healthy eyes, the age-adjusted AUROC was highest for wiVD (0.94), followed by RNFL thickness (0.92) and cpVD (0.83). The AUROCs for differentiating between healthy and glaucoma suspect eyes were highest for wiVD (0.70), followed by cpVD (0.65) and RNFL thickness (0.65). CONCLUSIONS. Optical coherence tomography angiography vessel density had similar diagnostic accuracy to RNFL thickness measurements for differentiating between healthy and glaucoma eyes. These results suggest that OCT-A measurements reflect damage to tissues relevant to the pathophysiology of OAG.

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