Optically Active Derivatives Of Imidazolines. α-Adrenergic Blocking Properties

Fu Lian Hsu, Akihiko Hamada, Mark E. Booher, H. Fuder, P. N. Patil, Duane Miller

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The synthesis and α-adrenergic blocking activity of a series of optically active 2, 4-disubstituted imidazolines are presented. The substituted analogues of naphazoline, tolazoline, and clonidine possess moderate a-adrenergic blocking activity with-log KBvalues in the range from 4.77 to 6.57. The differences between the α-adrenergic blocking activity of the stereoisomers of the 2, 4-disubstituted imidazolines were small or insignificant in the rabbit aortic tissue preparations.

Original languageEnglish (US)
Pages (from-to)1232-1235
Number of pages4
JournalJournal of Medicinal Chemistry
Volume23
Issue number11
DOIs
StatePublished - Nov 1 1980
Externally publishedYes

Fingerprint

Imidazolines
Adrenergic Agents
Tolazoline
Naphazoline
Stereoisomerism
Clonidine
Rabbits

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

Cite this

Optically Active Derivatives Of Imidazolines. α-Adrenergic Blocking Properties. / Hsu, Fu Lian; Hamada, Akihiko; Booher, Mark E.; Fuder, H.; Patil, P. N.; Miller, Duane.

In: Journal of Medicinal Chemistry, Vol. 23, No. 11, 01.11.1980, p. 1232-1235.

Research output: Contribution to journalArticle

Hsu, Fu Lian ; Hamada, Akihiko ; Booher, Mark E. ; Fuder, H. ; Patil, P. N. ; Miller, Duane. / Optically Active Derivatives Of Imidazolines. α-Adrenergic Blocking Properties. In: Journal of Medicinal Chemistry. 1980 ; Vol. 23, No. 11. pp. 1232-1235.
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