Optimal management of hypertension in patients with ischemic heart disease

Debabrata Mukherjee, Charles Campbell

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Epidemiological studies suggest a strong association between hypertension and ischemic heart disease (IHD), and hypertension is a major independent risk factor for the development of cardiovascular disease (CVD) including myocardial infarction (MI) and stroke. The primary objective of the management of hypertension in patients with IHD is modification of the balance between myocardial oxygen supply and demand to improve symptoms and reduce future cardiovascular adverse events. Patients with hypertension and heart failure constitute another important cohort in this high risk group. While several classes of antihypertensive agents have been shown to be beneficial in treating these patients, there are also several classes of drugs that should be avoided when treating hypertension in patients with IHD and heart failure. This review discusses which antihypertensive drugs should be used in patients who have established IHD with angina pectoris, in those with acute coronary syndromes and MI, and in those with heart failure. These recommendations are based on current guidelines. Finally, although there may be some differences in cardiovascular risk reduction among antihypertensive agents, the most important objective in hypertension management is to adequately control blood pressure irrespective of the agent used.

Original languageEnglish (US)
Pages (from-to)198-205
Number of pages8
JournalCardiovascular and Hematological Agents in Medicinal Chemistry
Volume7
Issue number3
DOIs
StatePublished - Oct 5 2009

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Myocardial Ischemia
Hypertension
Antihypertensive Agents
Heart Failure
Myocardial Infarction
Angina Pectoris
Risk Reduction Behavior
Acute Coronary Syndrome
Epidemiologic Studies
Cardiovascular Diseases
Stroke
Guidelines
Oxygen
Blood Pressure
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Hematology
  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Optimal management of hypertension in patients with ischemic heart disease. / Mukherjee, Debabrata; Campbell, Charles.

In: Cardiovascular and Hematological Agents in Medicinal Chemistry, Vol. 7, No. 3, 05.10.2009, p. 198-205.

Research output: Contribution to journalReview article

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