Optimizing imaging time for improved performance in oncology PET studies

Joseph A. Thie, Karl Hubner, Gary T. Smith

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Purpose: The potential for improving the diagnostic performance of static positron imaging tomography (PET) by judiciously choosing optimum post-injection imaging times is investigated. Procedures: Dynamic and whole-body scan data, from 2-deoxy-2-[18F]fluoro-D-glucose (FDG) oncological studies, are analyzed for changing standardized uptake value (SUV) behavior with increasing post-injection times at either single- or multiple-bed positions. Model-based interpretations address d(SUV)/dt, shown to correlate with SUV, and the contrast ratio for a tumor and its surroundings. A method for correcting measurements to a standardized time is given. Results: Both data and model-based equations suggest that starting data acquisition later than the average 55 ± 15 (SD) minutes post-injection reported in the FDG literature can improve contrast ratios. Considerations for choosing an optimum time from a clinical stand-point are listed. Conclusions: It is concluded that the appropriate time for each particular protocol can be found with the aid of the information presented here. True optimization, however, remains a complex issue.

Original languageEnglish (US)
Pages (from-to)238-244
Number of pages7
JournalMolecular Imaging and Biology
Volume4
Issue number3
DOIs
StatePublished - Jan 1 2002

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Injections
Whole Body Imaging
Fluorodeoxyglucose F18
Tomography
Electrons
Glucose
Neoplasms
caN protocol

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Optimizing imaging time for improved performance in oncology PET studies. / Thie, Joseph A.; Hubner, Karl; Smith, Gary T.

In: Molecular Imaging and Biology, Vol. 4, No. 3, 01.01.2002, p. 238-244.

Research output: Contribution to journalArticle

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