Oral maxillary squamous carcinoma

An indication for neck dissection in the clinically negative neck

David M. Montes, Eric Carlson, Rui Fernandes, G. E. Ghali, Joshua Lubek, Robert Ord, Bryan Bell, Eric Dierks, Brian L. Schmidt

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background This multicenter study was undertaken to characterize the metastatic behavior of oral maxillary squamous carcinoma and to determine the role of selective neck dissection. Methods A retrospective, multicenter study of patients surgically treated for oral maxillary squamous carcinoma was completed. Data collected included primary tumor location, cervical lymph node status, and neck failure rate. Results The study included 146 patients. The adjusted regional metastatic rate was 31.4%. Of those N0 (clinically negative) necks treated with or without neck dissection, 14.4% developed cervical metastasis. Within the cohort, 7.5% of patients died with distant disease. The regional salvage rate was 52.9%. None of the patients with locoregional failures were salvaged. Conclusions Maxillary palatal, alveolar, and gingival squamous carcinomas exhibit aggressive regional metastatic behavior. Surgical salvage rates for neck failure are low; therefore, selective neck dissection (levels I-III) is recommended at the time of resection of T2, T3, and T4 maxillary squamous carcinomas.

Original languageEnglish (US)
Pages (from-to)1581-1585
Number of pages5
JournalHead and Neck
Volume33
Issue number11
DOIs
StatePublished - Nov 1 2011
Externally publishedYes

Fingerprint

Neck Dissection
Squamous Cell Carcinoma
Neck
Multicenter Studies
Retrospective Studies
Lymph Nodes
Neoplasm Metastasis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Montes, D. M., Carlson, E., Fernandes, R., Ghali, G. E., Lubek, J., Ord, R., ... Schmidt, B. L. (2011). Oral maxillary squamous carcinoma: An indication for neck dissection in the clinically negative neck. Head and Neck, 33(11), 1581-1585. https://doi.org/10.1002/hed.21631

Oral maxillary squamous carcinoma : An indication for neck dissection in the clinically negative neck. / Montes, David M.; Carlson, Eric; Fernandes, Rui; Ghali, G. E.; Lubek, Joshua; Ord, Robert; Bell, Bryan; Dierks, Eric; Schmidt, Brian L.

In: Head and Neck, Vol. 33, No. 11, 01.11.2011, p. 1581-1585.

Research output: Contribution to journalArticle

Montes, DM, Carlson, E, Fernandes, R, Ghali, GE, Lubek, J, Ord, R, Bell, B, Dierks, E & Schmidt, BL 2011, 'Oral maxillary squamous carcinoma: An indication for neck dissection in the clinically negative neck', Head and Neck, vol. 33, no. 11, pp. 1581-1585. https://doi.org/10.1002/hed.21631
Montes, David M. ; Carlson, Eric ; Fernandes, Rui ; Ghali, G. E. ; Lubek, Joshua ; Ord, Robert ; Bell, Bryan ; Dierks, Eric ; Schmidt, Brian L. / Oral maxillary squamous carcinoma : An indication for neck dissection in the clinically negative neck. In: Head and Neck. 2011 ; Vol. 33, No. 11. pp. 1581-1585.
@article{290cc54e995943129036b29f645221e9,
title = "Oral maxillary squamous carcinoma: An indication for neck dissection in the clinically negative neck",
abstract = "Background This multicenter study was undertaken to characterize the metastatic behavior of oral maxillary squamous carcinoma and to determine the role of selective neck dissection. Methods A retrospective, multicenter study of patients surgically treated for oral maxillary squamous carcinoma was completed. Data collected included primary tumor location, cervical lymph node status, and neck failure rate. Results The study included 146 patients. The adjusted regional metastatic rate was 31.4{\%}. Of those N0 (clinically negative) necks treated with or without neck dissection, 14.4{\%} developed cervical metastasis. Within the cohort, 7.5{\%} of patients died with distant disease. The regional salvage rate was 52.9{\%}. None of the patients with locoregional failures were salvaged. Conclusions Maxillary palatal, alveolar, and gingival squamous carcinomas exhibit aggressive regional metastatic behavior. Surgical salvage rates for neck failure are low; therefore, selective neck dissection (levels I-III) is recommended at the time of resection of T2, T3, and T4 maxillary squamous carcinomas.",
author = "Montes, {David M.} and Eric Carlson and Rui Fernandes and Ghali, {G. E.} and Joshua Lubek and Robert Ord and Bryan Bell and Eric Dierks and Schmidt, {Brian L.}",
year = "2011",
month = "11",
day = "1",
doi = "10.1002/hed.21631",
language = "English (US)",
volume = "33",
pages = "1581--1585",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",
number = "11",

}

TY - JOUR

T1 - Oral maxillary squamous carcinoma

T2 - An indication for neck dissection in the clinically negative neck

AU - Montes, David M.

AU - Carlson, Eric

AU - Fernandes, Rui

AU - Ghali, G. E.

AU - Lubek, Joshua

AU - Ord, Robert

AU - Bell, Bryan

AU - Dierks, Eric

AU - Schmidt, Brian L.

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Background This multicenter study was undertaken to characterize the metastatic behavior of oral maxillary squamous carcinoma and to determine the role of selective neck dissection. Methods A retrospective, multicenter study of patients surgically treated for oral maxillary squamous carcinoma was completed. Data collected included primary tumor location, cervical lymph node status, and neck failure rate. Results The study included 146 patients. The adjusted regional metastatic rate was 31.4%. Of those N0 (clinically negative) necks treated with or without neck dissection, 14.4% developed cervical metastasis. Within the cohort, 7.5% of patients died with distant disease. The regional salvage rate was 52.9%. None of the patients with locoregional failures were salvaged. Conclusions Maxillary palatal, alveolar, and gingival squamous carcinomas exhibit aggressive regional metastatic behavior. Surgical salvage rates for neck failure are low; therefore, selective neck dissection (levels I-III) is recommended at the time of resection of T2, T3, and T4 maxillary squamous carcinomas.

AB - Background This multicenter study was undertaken to characterize the metastatic behavior of oral maxillary squamous carcinoma and to determine the role of selective neck dissection. Methods A retrospective, multicenter study of patients surgically treated for oral maxillary squamous carcinoma was completed. Data collected included primary tumor location, cervical lymph node status, and neck failure rate. Results The study included 146 patients. The adjusted regional metastatic rate was 31.4%. Of those N0 (clinically negative) necks treated with or without neck dissection, 14.4% developed cervical metastasis. Within the cohort, 7.5% of patients died with distant disease. The regional salvage rate was 52.9%. None of the patients with locoregional failures were salvaged. Conclusions Maxillary palatal, alveolar, and gingival squamous carcinomas exhibit aggressive regional metastatic behavior. Surgical salvage rates for neck failure are low; therefore, selective neck dissection (levels I-III) is recommended at the time of resection of T2, T3, and T4 maxillary squamous carcinomas.

UR - http://www.scopus.com/inward/record.url?scp=80054042476&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054042476&partnerID=8YFLogxK

U2 - 10.1002/hed.21631

DO - 10.1002/hed.21631

M3 - Article

VL - 33

SP - 1581

EP - 1585

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 11

ER -