Oral methotrexate for treatment of ectopic pregnancy

Gary H. Lipscomb, Norman Meyer, Darby E. Flynn, Matt Peterson, Frank W. Ling

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

OBJECTIVE: The purpose of this study was to evaluate oral methotrexate tablets in the treatment of ectopic pregnancy. STUDY DESIGN: Patients with a diagnosis of ectopic pregnancy were offered oral methotrexate tablets rather that intramuscular injection. Oral methotrexate wasgiven in 2 divided doses 2 hours apart at a dose of 60 mg/m2 with standard 2.5 mg methotrexate tablets. Patients were followed up with the use of the same protocol that was used typically for intramuscular methotrexate. RESULTS: Nineteen of 22 patients (86%) were successfully treated. There was no statistical difference between patients who were treated successfully or unsuccessfully, with respect to initial human chorionic gonadotropin titers (P =.55), ectopic size (P =.77), or methotrexate dose (P =.18). Nineteen of 22 patients (86%) had increased pain during treatment. Outside of pain, gastrointestinal side effects were the most common. Thirty-two percent of patients required more than one treatment cycle. CONCLUSION: Oral methotrexate can be used to treat ectopic pregnancy successfully, but there are few advantages to recommend its use over intramuscular methotrexate.

Original languageEnglish (US)
Pages (from-to)1192-1195
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume186
Issue number6
DOIs
StatePublished - Jan 1 2002

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Ectopic Pregnancy
Methotrexate
Tablets
Therapeutics
Pain
Intramuscular Injections
Chorionic Gonadotropin

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Oral methotrexate for treatment of ectopic pregnancy. / Lipscomb, Gary H.; Meyer, Norman; Flynn, Darby E.; Peterson, Matt; Ling, Frank W.

In: American Journal of Obstetrics and Gynecology, Vol. 186, No. 6, 01.01.2002, p. 1192-1195.

Research output: Contribution to journalArticle

Lipscomb, Gary H. ; Meyer, Norman ; Flynn, Darby E. ; Peterson, Matt ; Ling, Frank W. / Oral methotrexate for treatment of ectopic pregnancy. In: American Journal of Obstetrics and Gynecology. 2002 ; Vol. 186, No. 6. pp. 1192-1195.
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