Oral vaccine that breaks the transmission cycle of the Lyme disease spirochete can be delivered via bait

Maria Gomes-Solecki, Dustin R. Brisson, Raymond J. Dattwyler

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Borrelia burgdorferi causes Lyme disease, a potentially debilitating human disease for which no vaccine is currently available. We developed an oral bait delivery system for an anti-B. burgdorferi vaccine based in OspA. Mice were immunized orally via gavage and bait feeding. Challenge was performed via Ixodes scapularis field nymphs carrying multiple B. burgdorferi strains. Vaccination protected 89% of the mice and the systemic immune response was skewed toward IgG2a/2b production. Moreover, this oral vaccine reduced the pathogen in the tick vector by eight-fold. We conclude that this oral vaccine induces a protective systemic immune response against a variety of infectious B. burgdorferi strains found in nature and therefore it can eliminate this zoonotic pathogen from its major host reservoirs. Because we observed elimination of the spirochete from the tick vector, a broad delivery of this oral vaccine to wildlife reservoirs is likely to disrupt the transmission cycle of this pathogen.

Original languageEnglish (US)
Pages (from-to)4440-4449
Number of pages10
JournalVaccine
Volume24
Issue number20
DOIs
StatePublished - May 15 2006

Fingerprint

Borrelia burgdorferi
Lyme disease
baits
mouth
Vaccines
vaccines
Ticks
ticks
pathogens
immune response
Nymph
Ixodes
Spirochaetales
Ixodes scapularis
disease reservoirs
Infectious Disease Transmission
Lyme Disease
mice
Zoonoses
human diseases

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Oral vaccine that breaks the transmission cycle of the Lyme disease spirochete can be delivered via bait. / Gomes-Solecki, Maria; Brisson, Dustin R.; Dattwyler, Raymond J.

In: Vaccine, Vol. 24, No. 20, 15.05.2006, p. 4440-4449.

Research output: Contribution to journalArticle

Gomes-Solecki, Maria ; Brisson, Dustin R. ; Dattwyler, Raymond J. / Oral vaccine that breaks the transmission cycle of the Lyme disease spirochete can be delivered via bait. In: Vaccine. 2006 ; Vol. 24, No. 20. pp. 4440-4449.
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