Orbital inflammatory syndromes with systemic involvement may mimic metastatic disease

Melanie R. Foley, Darius M. Moshfeghi, Matthew Wilson, Barrett G. Haik, Alberto S. Pappo, D. Ashley Hill

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Physical examination of a 9-year-old girl with a 2-month history of swelling of the left orbit demonstrated an orbital mass, blepharoptosis, and proptosis. Computed tomography revealed a 2 x 3-cm mass in the superior left orbit that expanded orbital dimensions. Radiography showed abnormalities in the parietal and frontal bones and distal right tibia. Magnetic resonance imaging demonstrated an 8.5-cm abnormality of the marrow space of the right mid-tibia. Bone marrow biopsy was unremarkable. Orbital and tibial biopsies showed a nonspecific chronic inflammation. Idiopathic inflammation that involves the orbit (orbital pseudotumor) and that has systemic manifestations may mimic more serious conditions, such as metastases from rhabdomyosarcoma or Ewing sarcoma, chronic recurrent multifocal osteomyelitis (CRMO), and SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis). Accurate diagnosis requires careful clinical and pathologic examinations.

Original languageEnglish (US)
Pages (from-to)324-327
Number of pages4
JournalOphthalmic Plastic and Reconstructive Surgery
Volume19
Issue number4
DOIs
StatePublished - Jan 1 2003

Fingerprint

Orbit
Tibia
Orbital Pseudotumor
Bone Marrow
Parietal Bone
Blepharoptosis
Frontal Bone
Hyperostosis
Inflammation
Biopsy
Osteitis
Ewing's Sarcoma
Exophthalmos
Synovitis
Rhabdomyosarcoma
Acne Vulgaris
Radiography
Physical Examination
Tomography
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Surgery
  • Ophthalmology

Cite this

Orbital inflammatory syndromes with systemic involvement may mimic metastatic disease. / Foley, Melanie R.; Moshfeghi, Darius M.; Wilson, Matthew; Haik, Barrett G.; Pappo, Alberto S.; Hill, D. Ashley.

In: Ophthalmic Plastic and Reconstructive Surgery, Vol. 19, No. 4, 01.01.2003, p. 324-327.

Research output: Contribution to journalArticle

Foley, Melanie R. ; Moshfeghi, Darius M. ; Wilson, Matthew ; Haik, Barrett G. ; Pappo, Alberto S. ; Hill, D. Ashley. / Orbital inflammatory syndromes with systemic involvement may mimic metastatic disease. In: Ophthalmic Plastic and Reconstructive Surgery. 2003 ; Vol. 19, No. 4. pp. 324-327.
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