Organization of Plasmodium falciparum genome: 1. Evidence for a highly repeated DNA sequence

Ramareddy Guntaka, Siddarame Gowda, Arepalli S. Rao, Theodore J. Green

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Plasmodium falciparum DNA, isolated from the merozoite stage, was cleaved with HindIII and cloned in pBR322 and λL47.1 vectors. Plasmid clones containing 13.4, 7.0, 4.3, 4.1 and 1.5 kb inserts were characterized in some detail. The inserts contain several repeating units of smaller size. Nucleic acid hybridization studies showed that the repeat element is present in the Plasmodium DNA at a very high copy number and appears to be distributed widely throughout the genome.

Original languageEnglish (US)
Pages (from-to)1965-1975
Number of pages11
JournalNucleic acids research
Volume13
Issue number6
DOIs
StatePublished - Mar 25 1985

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Plasmodium falciparum
Genome
Nucleic Acid Hybridization
Merozoites
Plasmodium
DNA
Plasmids
Clone Cells

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Organization of Plasmodium falciparum genome : 1. Evidence for a highly repeated DNA sequence. / Guntaka, Ramareddy; Gowda, Siddarame; Rao, Arepalli S.; Green, Theodore J.

In: Nucleic acids research, Vol. 13, No. 6, 25.03.1985, p. 1965-1975.

Research output: Contribution to journalArticle

Guntaka, Ramareddy ; Gowda, Siddarame ; Rao, Arepalli S. ; Green, Theodore J. / Organization of Plasmodium falciparum genome : 1. Evidence for a highly repeated DNA sequence. In: Nucleic acids research. 1985 ; Vol. 13, No. 6. pp. 1965-1975.
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