Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19

S. M.G. Hoffman, David Nelson, D. S. Keeney

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

The cytochrome P450 superfamily of mixed-function oxygenases has been extensively studied due to its many critical metabolic roles, and also because it is a fascinating example of gene family evolution. The cluster of genes on human chromosome 19 from the CYP2A, 2B, and 2F subfamilies has been previously described as having a complex organization and many pseudogenes. We describe the discovery of genes from three more CYP2 subfamilies inside the cluster, and assemble a complete map of the region. We comprehensively review the organization, structure, and expression of genes from all six subfamilies. A general hypothesis for the evolution of this complex gene cluster is also presented.

Original languageEnglish (US)
Pages (from-to)687-698
Number of pages12
JournalPharmacogenetics
Volume11
Issue number8
DOIs
StatePublished - Dec 3 2001

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Chromosomes, Human, Pair 19
Human Chromosomes
Multigene Family
Pseudogenes
Genetic Association Studies
Mixed Function Oxygenases
Cytochrome P-450 Enzyme System
Gene Expression
Genes
steroid hormone 7-alpha-hydroxylase

All Science Journal Classification (ASJC) codes

  • Genetics
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19. / Hoffman, S. M.G.; Nelson, David; Keeney, D. S.

In: Pharmacogenetics, Vol. 11, No. 8, 03.12.2001, p. 687-698.

Research output: Contribution to journalArticle

Hoffman, S. M.G. ; Nelson, David ; Keeney, D. S. / Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19. In: Pharmacogenetics. 2001 ; Vol. 11, No. 8. pp. 687-698.
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