Osmolality of oral drug solutions and suspensions.

Roland Dickerson, G. Melnik

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The osmolality values of a variety of commonly used drug solutions and suspensions were determined. A total of 58 commercially available drug solutions and suspensions and electrolyte solutions for oral use were analyzed. Samples of each product were diluted 1:10 to a total volume of 100 microL with sterile water for irrigation and mixed thoroughly. The osmolality of 10-microL aliquots of each diluted mixture was determined at least in duplicate by vapor pressure osmometry. Only six (10%) of the products had osmolality values that were less than or equal to 1000 mOsm/kg (i.e., similar to the values of commercially available enteral formulas). The other products had osmolality values ranging from 1,050 to 10,950 mOsm/kg. Since many drug solutions and suspensions are hypertonic compared with normal gastrointestinal secretions, inappropriate administration could cause adverse gastrointestinal effects in patients receiving enteral nutrition support.

Original languageEnglish (US)
Pages (from-to)832-834
Number of pages3
JournalAmerican Journal of Hospital Pharmacy
Volume45
Issue number4
StatePublished - Apr 1 1988

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Osmolar Concentration
Suspensions
Pharmaceutical Preparations
Osmometry
Hypertonic Solutions
Vapor Pressure
Enteral Nutrition
Electrolytes
Small Intestine
Water

All Science Journal Classification (ASJC) codes

  • Leadership and Management
  • Pharmaceutical Science

Cite this

Osmolality of oral drug solutions and suspensions. / Dickerson, Roland; Melnik, G.

In: American Journal of Hospital Pharmacy, Vol. 45, No. 4, 01.04.1988, p. 832-834.

Research output: Contribution to journalArticle

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