Osseous complications of renal transplantation

David W. Butterly, Leigh Quarles

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Osseous complications are an important cause of long-term morbidity in renal transplant recipients. The etiology of these complications is multifactorial and relates to abnormalities of calcium homeostasis that persist after engraftment along with toxic effects of immunosuppression. Though we do not yet have a proven strategy to prevent or treat these osseous disorders, effective control of secondary hyperparathyroidism as well as strategies to limit bone loss may prove beneficial, particularly with regard to avoiding the rapid initial bone loss after transplantation. In addition to steroid sparing strategies, potential treatments that include antiresorptive agents (such as calcitonin or bisphosphonates) or anabolic agents which antagonize the effects of corticosteroid (such as rhGH) may be useful. Clinical trials are needed to examine the potential benefit of anti-resorptive and osteoinductive agents in allograft recipients. Although the overall incidence of osseous complications may be decreasing, improved graft survival rates will ensure that skeletal complications remain a significant clinical problem.

Original languageEnglish (US)
Pages (from-to)353-359
Number of pages7
JournalSeminars in Dialysis
Volume9
Issue number4
StatePublished - Jul 1 1996

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Kidney Transplantation
Bone Density Conservation Agents
Anabolic Agents
Bone and Bones
Secondary Hyperparathyroidism
Poisons
Diphosphonates
Calcitonin
Graft Survival
Immunosuppression
Allografts
Adrenal Cortex Hormones
Homeostasis
Survival Rate
Transplantation
Steroids
Clinical Trials
Calcium
Morbidity
Kidney

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Osseous complications of renal transplantation. / Butterly, David W.; Quarles, Leigh.

In: Seminars in Dialysis, Vol. 9, No. 4, 01.07.1996, p. 353-359.

Research output: Contribution to journalArticle

Butterly, David W. ; Quarles, Leigh. / Osseous complications of renal transplantation. In: Seminars in Dialysis. 1996 ; Vol. 9, No. 4. pp. 353-359.
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