Ossifying plexiform tumor

Solomon S. Lee, Brian L. Baker, Joshua D.G. Gapp, Andrew E. Rosenberg, Paul Googe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report a rare case of ossifying plexiform tumor in a 64-year-old female. The patient had a 2-year history of gradual hardening of the right thumb pad and pain that radiated up the forearm. Physical examination showed a tender, mobile 2-cm subcutaneous nodule distending the tip of the right thumb. The biopsy specimen showed a well-delineated tumor with multiple lobules of epithelioid and spindled cells arranged in a plexiform pattern separated by fibrous bands and having foci of bone formation. The neoplastic cells had scant-to-moderate amphophilic cytoplasm with mild nuclear pleomorphism in a myxocollagenous background. No necrosis, mitoses or cytological atypicia were seen. The osteocytes present in the bone islands were bland, with occasional rimming osteoblasts. X-ray showed stippled calcification in the soft tissue of the distal thumb without involvement of the phalanx. The patient is tumor free for 1 year after complete local excision. Only three cases of ossifying plexiform tumor have been reported. All previous cases and the current case presented as subcutaneous nodules on hand digits of females, measuring 1-2 cm in greatest dimension. Ossifying plexiform tumor appears to be a benign neoplasm with no reports of progression or metastasis.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalJournal of cutaneous pathology
Volume42
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Thumb
Neoplasms
Osteocytes
Epithelioid Cells
Osteoblasts
Mitosis
Forearm
Osteogenesis
Physical Examination
Cytoplasm
Necrosis
Hand
X-Rays
Neoplasm Metastasis
Biopsy
Bone and Bones
Pain

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Cite this

Lee, S. S., Baker, B. L., Gapp, J. D. G., Rosenberg, A. E., & Googe, P. (2015). Ossifying plexiform tumor. Journal of cutaneous pathology, 42(1), 61-65. https://doi.org/10.1111/cup.12449

Ossifying plexiform tumor. / Lee, Solomon S.; Baker, Brian L.; Gapp, Joshua D.G.; Rosenberg, Andrew E.; Googe, Paul.

In: Journal of cutaneous pathology, Vol. 42, No. 1, 01.01.2015, p. 61-65.

Research output: Contribution to journalArticle

Lee, SS, Baker, BL, Gapp, JDG, Rosenberg, AE & Googe, P 2015, 'Ossifying plexiform tumor', Journal of cutaneous pathology, vol. 42, no. 1, pp. 61-65. https://doi.org/10.1111/cup.12449
Lee SS, Baker BL, Gapp JDG, Rosenberg AE, Googe P. Ossifying plexiform tumor. Journal of cutaneous pathology. 2015 Jan 1;42(1):61-65. https://doi.org/10.1111/cup.12449
Lee, Solomon S. ; Baker, Brian L. ; Gapp, Joshua D.G. ; Rosenberg, Andrew E. ; Googe, Paul. / Ossifying plexiform tumor. In: Journal of cutaneous pathology. 2015 ; Vol. 42, No. 1. pp. 61-65.
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