Osteoporosis management program decreases incidence of hip fracture in patients with prostate cancer receiving androgen deprivation therapy

Ali Asghar Zhumkhawala, Joseph Gleason, T. Craig Cheetham, Fang Niu, Ronald K. Loo, Richard M. Dell, Steven J. Jacobsen, Gary W. Chien

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: To evaluate the incidence of hip fracture in men with prostate cancer receiving androgen deprivation therapy (ADT). Materials and Methods: One of the detrimental side effects of ADT for prostate cancer is osteoporosis. Through an osteoporosis prevention program implemented in our healthcare system, the patients at risk undergo dual x-ray absorptiometry scans and receive treatment if the T-score indicates bone loss. We evaluated the incidence of hip fracture in men with prostate cancer who were receiving ADT through a retrospective, cohort study conducted within a managed care organization. The participants were all men newly diagnosed with prostate cancer from January 2003 to December 2007 receiving leuprolide injections. Patients who had had a dual x-ray absorptiometry scan beginning 3 months before the index date through the end of study were included in the intervention group; all others were included in the comparison group. The main outcome of interest was a hip fracture occurring after the index date, excluding cancer pathologic fractures, traumatic fractures, and fractures associated with epilepsy. Results: A total of 1071 patients were in the intervention group, and 411 were in the comparison group. In the intervention group, 18 hip fractures occurred compared with 17 in the comparison group. The incidence rate of hip fractures per 1000 person-years was 5.1 (95% confidence interval 3.0-8.0) in the intervention group and 18.1 (95% confidence interval 10.5-29.0) in the comparison group. Conclusion: The incidence rate of hip fracture in this population was reduced >70% with enrollment in an osteoporosis management system, avoiding this morbid complication of ADT.

Original languageEnglish (US)
Pages (from-to)1010-1017
Number of pages8
JournalUrology
Volume81
Issue number5
DOIs
StatePublished - May 1 2013
Externally publishedYes

Fingerprint

Hip Fractures
Androgens
Osteoporosis
Prostatic Neoplasms
Incidence
Therapeutics
X-Rays
Confidence Intervals
Leuprolide
Spontaneous Fractures
Managed Care Programs
Epilepsy
Cohort Studies
Retrospective Studies
Organizations
Delivery of Health Care
Bone and Bones
Injections
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Osteoporosis management program decreases incidence of hip fracture in patients with prostate cancer receiving androgen deprivation therapy. / Zhumkhawala, Ali Asghar; Gleason, Joseph; Craig Cheetham, T.; Niu, Fang; Loo, Ronald K.; Dell, Richard M.; Jacobsen, Steven J.; Chien, Gary W.

In: Urology, Vol. 81, No. 5, 01.05.2013, p. 1010-1017.

Research output: Contribution to journalArticle

Zhumkhawala, Ali Asghar ; Gleason, Joseph ; Craig Cheetham, T. ; Niu, Fang ; Loo, Ronald K. ; Dell, Richard M. ; Jacobsen, Steven J. ; Chien, Gary W. / Osteoporosis management program decreases incidence of hip fracture in patients with prostate cancer receiving androgen deprivation therapy. In: Urology. 2013 ; Vol. 81, No. 5. pp. 1010-1017.
@article{606a0dfd0400463db279beb217ca3853,
title = "Osteoporosis management program decreases incidence of hip fracture in patients with prostate cancer receiving androgen deprivation therapy",
abstract = "Objective: To evaluate the incidence of hip fracture in men with prostate cancer receiving androgen deprivation therapy (ADT). Materials and Methods: One of the detrimental side effects of ADT for prostate cancer is osteoporosis. Through an osteoporosis prevention program implemented in our healthcare system, the patients at risk undergo dual x-ray absorptiometry scans and receive treatment if the T-score indicates bone loss. We evaluated the incidence of hip fracture in men with prostate cancer who were receiving ADT through a retrospective, cohort study conducted within a managed care organization. The participants were all men newly diagnosed with prostate cancer from January 2003 to December 2007 receiving leuprolide injections. Patients who had had a dual x-ray absorptiometry scan beginning 3 months before the index date through the end of study were included in the intervention group; all others were included in the comparison group. The main outcome of interest was a hip fracture occurring after the index date, excluding cancer pathologic fractures, traumatic fractures, and fractures associated with epilepsy. Results: A total of 1071 patients were in the intervention group, and 411 were in the comparison group. In the intervention group, 18 hip fractures occurred compared with 17 in the comparison group. The incidence rate of hip fractures per 1000 person-years was 5.1 (95{\%} confidence interval 3.0-8.0) in the intervention group and 18.1 (95{\%} confidence interval 10.5-29.0) in the comparison group. Conclusion: The incidence rate of hip fracture in this population was reduced >70{\%} with enrollment in an osteoporosis management system, avoiding this morbid complication of ADT.",
author = "Zhumkhawala, {Ali Asghar} and Joseph Gleason and {Craig Cheetham}, T. and Fang Niu and Loo, {Ronald K.} and Dell, {Richard M.} and Jacobsen, {Steven J.} and Chien, {Gary W.}",
year = "2013",
month = "5",
day = "1",
doi = "10.1016/j.urology.2012.11.066",
language = "English (US)",
volume = "81",
pages = "1010--1017",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Osteoporosis management program decreases incidence of hip fracture in patients with prostate cancer receiving androgen deprivation therapy

AU - Zhumkhawala, Ali Asghar

AU - Gleason, Joseph

AU - Craig Cheetham, T.

AU - Niu, Fang

AU - Loo, Ronald K.

AU - Dell, Richard M.

AU - Jacobsen, Steven J.

AU - Chien, Gary W.

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Objective: To evaluate the incidence of hip fracture in men with prostate cancer receiving androgen deprivation therapy (ADT). Materials and Methods: One of the detrimental side effects of ADT for prostate cancer is osteoporosis. Through an osteoporosis prevention program implemented in our healthcare system, the patients at risk undergo dual x-ray absorptiometry scans and receive treatment if the T-score indicates bone loss. We evaluated the incidence of hip fracture in men with prostate cancer who were receiving ADT through a retrospective, cohort study conducted within a managed care organization. The participants were all men newly diagnosed with prostate cancer from January 2003 to December 2007 receiving leuprolide injections. Patients who had had a dual x-ray absorptiometry scan beginning 3 months before the index date through the end of study were included in the intervention group; all others were included in the comparison group. The main outcome of interest was a hip fracture occurring after the index date, excluding cancer pathologic fractures, traumatic fractures, and fractures associated with epilepsy. Results: A total of 1071 patients were in the intervention group, and 411 were in the comparison group. In the intervention group, 18 hip fractures occurred compared with 17 in the comparison group. The incidence rate of hip fractures per 1000 person-years was 5.1 (95% confidence interval 3.0-8.0) in the intervention group and 18.1 (95% confidence interval 10.5-29.0) in the comparison group. Conclusion: The incidence rate of hip fracture in this population was reduced >70% with enrollment in an osteoporosis management system, avoiding this morbid complication of ADT.

AB - Objective: To evaluate the incidence of hip fracture in men with prostate cancer receiving androgen deprivation therapy (ADT). Materials and Methods: One of the detrimental side effects of ADT for prostate cancer is osteoporosis. Through an osteoporosis prevention program implemented in our healthcare system, the patients at risk undergo dual x-ray absorptiometry scans and receive treatment if the T-score indicates bone loss. We evaluated the incidence of hip fracture in men with prostate cancer who were receiving ADT through a retrospective, cohort study conducted within a managed care organization. The participants were all men newly diagnosed with prostate cancer from January 2003 to December 2007 receiving leuprolide injections. Patients who had had a dual x-ray absorptiometry scan beginning 3 months before the index date through the end of study were included in the intervention group; all others were included in the comparison group. The main outcome of interest was a hip fracture occurring after the index date, excluding cancer pathologic fractures, traumatic fractures, and fractures associated with epilepsy. Results: A total of 1071 patients were in the intervention group, and 411 were in the comparison group. In the intervention group, 18 hip fractures occurred compared with 17 in the comparison group. The incidence rate of hip fractures per 1000 person-years was 5.1 (95% confidence interval 3.0-8.0) in the intervention group and 18.1 (95% confidence interval 10.5-29.0) in the comparison group. Conclusion: The incidence rate of hip fracture in this population was reduced >70% with enrollment in an osteoporosis management system, avoiding this morbid complication of ADT.

UR - http://www.scopus.com/inward/record.url?scp=84876693717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876693717&partnerID=8YFLogxK

U2 - 10.1016/j.urology.2012.11.066

DO - 10.1016/j.urology.2012.11.066

M3 - Article

VL - 81

SP - 1010

EP - 1017

JO - Urology

JF - Urology

SN - 0090-4295

IS - 5

ER -