Outcome in hyperglycemic stroke with ultrasound-augmented thrombolytic therapy

S. R. Martini, M. D. Hill, Andrei Alexandrov, C. A. Molina, T. A. Kent

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Hyperglycemia independently predicts poor outcome after acute ischemic stroke. CLOTBUST (Combined Lysis Of Thrombus in Brain ischemia using transcranial Ultrasound and Systemic tPA) demonstrated that ultrasound-augmented thrombolysis improves recanalization and 24-hour outcome in patients with acute ischemic stroke. We hypothesized that ultrasound would preferentially benefit hyperglycemic patients, and reviewed CLOTBUST with respect to admission glucose and good outcome. We found that ultrasound's benefit on 90-day outcome was primarily apparent at higher glucose levels, suggesting that ultrasound therapy may improve outcome following hyperglycemic stroke.

Original languageEnglish (US)
Pages (from-to)700-702
Number of pages3
JournalNeurology
Volume67
Issue number4
DOIs
StatePublished - Aug 1 2006
Externally publishedYes

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Thrombolytic Therapy
Stroke
Glucose
Brain Ischemia
Hyperglycemia
Thrombosis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Outcome in hyperglycemic stroke with ultrasound-augmented thrombolytic therapy. / Martini, S. R.; Hill, M. D.; Alexandrov, Andrei; Molina, C. A.; Kent, T. A.

In: Neurology, Vol. 67, No. 4, 01.08.2006, p. 700-702.

Research output: Contribution to journalArticle

Martini, S. R. ; Hill, M. D. ; Alexandrov, Andrei ; Molina, C. A. ; Kent, T. A. / Outcome in hyperglycemic stroke with ultrasound-augmented thrombolytic therapy. In: Neurology. 2006 ; Vol. 67, No. 4. pp. 700-702.
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