Outcome of childhood acute lymphoblastic leukaemia in resource-poor countries

Monika L. Metzger, Scott Howard, Ligia C. Fu, Armando Peña, Rene Stefan, Michael L. Hancock, Zhe Zhang, Ching Hon Pui, Judy Wilimas, Raul C. Ribeiro

Research output: Contribution to journalArticle

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Abstract

The causes of treatment failure in childhood acute lymphoblastic leukaemia are thought to differ between resource-rich and resource-poor countries. We assessed the records of 168 patients treated for this disease in Honduras. Abandonment of treatment (n=38), the main cause of failure, was associated with prolonged travel time to the treatment facility (2-5 h: hazard ratio 3.1, 95% CI 1.2-8.1 vs >5 h: 3.7, 1.3-10.9) and age younger than 4.5 years (2.6, 1.1-6.3). 35 patients died of treatment-related effects. Outcome could be substantially improved by interventions that help to prevent abandonment of therapy (such as funding for transport, satellite clinics, and support groups), and by prompt treatment of infection.

Original languageEnglish (US)
Pages (from-to)706-708
Number of pages3
JournalLancet
Volume362
Issue number9385
DOIs
StatePublished - Aug 30 2003
Externally publishedYes

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Honduras
Therapeutics
Self-Help Groups
Treatment Failure
Infection

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Metzger, M. L., Howard, S., Fu, L. C., Peña, A., Stefan, R., Hancock, M. L., ... Ribeiro, R. C. (2003). Outcome of childhood acute lymphoblastic leukaemia in resource-poor countries. Lancet, 362(9385), 706-708. https://doi.org/10.1016/S0140-6736(03)14228-6

Outcome of childhood acute lymphoblastic leukaemia in resource-poor countries. / Metzger, Monika L.; Howard, Scott; Fu, Ligia C.; Peña, Armando; Stefan, Rene; Hancock, Michael L.; Zhang, Zhe; Pui, Ching Hon; Wilimas, Judy; Ribeiro, Raul C.

In: Lancet, Vol. 362, No. 9385, 30.08.2003, p. 706-708.

Research output: Contribution to journalArticle

Metzger, ML, Howard, S, Fu, LC, Peña, A, Stefan, R, Hancock, ML, Zhang, Z, Pui, CH, Wilimas, J & Ribeiro, RC 2003, 'Outcome of childhood acute lymphoblastic leukaemia in resource-poor countries', Lancet, vol. 362, no. 9385, pp. 706-708. https://doi.org/10.1016/S0140-6736(03)14228-6
Metzger, Monika L. ; Howard, Scott ; Fu, Ligia C. ; Peña, Armando ; Stefan, Rene ; Hancock, Michael L. ; Zhang, Zhe ; Pui, Ching Hon ; Wilimas, Judy ; Ribeiro, Raul C. / Outcome of childhood acute lymphoblastic leukaemia in resource-poor countries. In: Lancet. 2003 ; Vol. 362, No. 9385. pp. 706-708.
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