Outcomes after cataract extraction in young children with radiation-induced cataracts and retinoblastoma

Mary Ellen Hoehn, Farhan Irshad, Natalie C. Kerr, Matthew Wilson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: An expected side effect of external beam radiation therapy for retinoblastoma is cataract formation, which impairs a child's visual development and an ophthalmologist's ability to examine the eye. When surgery is indicated, the potential complications can be vision-or life-threatening. Here we report the results of cataract extraction with intraocular lens placement in young children with retinoblastoma. Methods: A retrospective chart review of all patients at St. Jude's Children's Research Hospital who had undergone external beam radiation therapy for retinoblastoma during a 25-year period was performed. Patients who required cataract extraction with IOL placement were included. Preoperative and postoperative visual acuity and ocular complications were recorded. Results: The chart review identified 40 patients (53 eyes) with cataracts, of whom 15 (19 eyes) had surgery. Of the 19 eyes, 2 (10.5%) developed a vitreous hemorrhage (one of which was subsequently enucleated secondary to phthisis, whereas the other resolved without further complications). A total of 12 eyes (63.2%) required Nd:YAG laser capsulotomies (mean, 3.6 months; range, 1-7 months). None developed recurrence or spread of disease. Thirteen eyes (68.4%) had improved visual acuity after cataract extraction and intraocular lens placement, 4 of which (30.8%) subsequently lost vision as the result of other complications of retinoblastoma treatment. Visual acuity outcomes were 20/20 to 20/60 in 3 eyes (15.8%); 20/70 to 20/200 in 4 (21.1%); and 20/400 or less in 10 (52.6%). One patient (5.2%) required enucleation. Conclusions: Patients who underwent cataract extraction after treatment for retinoblastoma had few postoperative adverse outcomes, and visual acuity improved in most patients immediately after surgery. However, some patients who showed initial improvement subsequently lost vision as the result of other complications from retinoblastoma treatment. ( J AAPOS 2010;14:232-234)

Original languageEnglish (US)
Pages (from-to)232-234
Number of pages3
JournalJournal of AAPOS
Volume14
Issue number3
DOIs
StatePublished - Jun 1 2010

Fingerprint

Cataract Extraction
Retinoblastoma
Cataract
Radiation
Visual Acuity
Intraocular Lenses
Radiotherapy
Vitreous Hemorrhage
Aptitude
Solid-State Lasers
Child Development
Therapeutics
Recurrence
Research

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Pediatrics, Perinatology, and Child Health

Cite this

Outcomes after cataract extraction in young children with radiation-induced cataracts and retinoblastoma. / Hoehn, Mary Ellen; Irshad, Farhan; Kerr, Natalie C.; Wilson, Matthew.

In: Journal of AAPOS, Vol. 14, No. 3, 01.06.2010, p. 232-234.

Research output: Contribution to journalArticle

Hoehn, Mary Ellen ; Irshad, Farhan ; Kerr, Natalie C. ; Wilson, Matthew. / Outcomes after cataract extraction in young children with radiation-induced cataracts and retinoblastoma. In: Journal of AAPOS. 2010 ; Vol. 14, No. 3. pp. 232-234.
@article{450561e9241b4c10a5ab1801d6a0c11c,
title = "Outcomes after cataract extraction in young children with radiation-induced cataracts and retinoblastoma",
abstract = "Background: An expected side effect of external beam radiation therapy for retinoblastoma is cataract formation, which impairs a child's visual development and an ophthalmologist's ability to examine the eye. When surgery is indicated, the potential complications can be vision-or life-threatening. Here we report the results of cataract extraction with intraocular lens placement in young children with retinoblastoma. Methods: A retrospective chart review of all patients at St. Jude's Children's Research Hospital who had undergone external beam radiation therapy for retinoblastoma during a 25-year period was performed. Patients who required cataract extraction with IOL placement were included. Preoperative and postoperative visual acuity and ocular complications were recorded. Results: The chart review identified 40 patients (53 eyes) with cataracts, of whom 15 (19 eyes) had surgery. Of the 19 eyes, 2 (10.5{\%}) developed a vitreous hemorrhage (one of which was subsequently enucleated secondary to phthisis, whereas the other resolved without further complications). A total of 12 eyes (63.2{\%}) required Nd:YAG laser capsulotomies (mean, 3.6 months; range, 1-7 months). None developed recurrence or spread of disease. Thirteen eyes (68.4{\%}) had improved visual acuity after cataract extraction and intraocular lens placement, 4 of which (30.8{\%}) subsequently lost vision as the result of other complications of retinoblastoma treatment. Visual acuity outcomes were 20/20 to 20/60 in 3 eyes (15.8{\%}); 20/70 to 20/200 in 4 (21.1{\%}); and 20/400 or less in 10 (52.6{\%}). One patient (5.2{\%}) required enucleation. Conclusions: Patients who underwent cataract extraction after treatment for retinoblastoma had few postoperative adverse outcomes, and visual acuity improved in most patients immediately after surgery. However, some patients who showed initial improvement subsequently lost vision as the result of other complications from retinoblastoma treatment. ( J AAPOS 2010;14:232-234)",
author = "Hoehn, {Mary Ellen} and Farhan Irshad and Kerr, {Natalie C.} and Matthew Wilson",
year = "2010",
month = "6",
day = "1",
doi = "10.1016/j.jaapos.2010.01.012",
language = "English (US)",
volume = "14",
pages = "232--234",
journal = "Journal of AAPOS",
issn = "1091-8531",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Outcomes after cataract extraction in young children with radiation-induced cataracts and retinoblastoma

AU - Hoehn, Mary Ellen

AU - Irshad, Farhan

AU - Kerr, Natalie C.

AU - Wilson, Matthew

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Background: An expected side effect of external beam radiation therapy for retinoblastoma is cataract formation, which impairs a child's visual development and an ophthalmologist's ability to examine the eye. When surgery is indicated, the potential complications can be vision-or life-threatening. Here we report the results of cataract extraction with intraocular lens placement in young children with retinoblastoma. Methods: A retrospective chart review of all patients at St. Jude's Children's Research Hospital who had undergone external beam radiation therapy for retinoblastoma during a 25-year period was performed. Patients who required cataract extraction with IOL placement were included. Preoperative and postoperative visual acuity and ocular complications were recorded. Results: The chart review identified 40 patients (53 eyes) with cataracts, of whom 15 (19 eyes) had surgery. Of the 19 eyes, 2 (10.5%) developed a vitreous hemorrhage (one of which was subsequently enucleated secondary to phthisis, whereas the other resolved without further complications). A total of 12 eyes (63.2%) required Nd:YAG laser capsulotomies (mean, 3.6 months; range, 1-7 months). None developed recurrence or spread of disease. Thirteen eyes (68.4%) had improved visual acuity after cataract extraction and intraocular lens placement, 4 of which (30.8%) subsequently lost vision as the result of other complications of retinoblastoma treatment. Visual acuity outcomes were 20/20 to 20/60 in 3 eyes (15.8%); 20/70 to 20/200 in 4 (21.1%); and 20/400 or less in 10 (52.6%). One patient (5.2%) required enucleation. Conclusions: Patients who underwent cataract extraction after treatment for retinoblastoma had few postoperative adverse outcomes, and visual acuity improved in most patients immediately after surgery. However, some patients who showed initial improvement subsequently lost vision as the result of other complications from retinoblastoma treatment. ( J AAPOS 2010;14:232-234)

AB - Background: An expected side effect of external beam radiation therapy for retinoblastoma is cataract formation, which impairs a child's visual development and an ophthalmologist's ability to examine the eye. When surgery is indicated, the potential complications can be vision-or life-threatening. Here we report the results of cataract extraction with intraocular lens placement in young children with retinoblastoma. Methods: A retrospective chart review of all patients at St. Jude's Children's Research Hospital who had undergone external beam radiation therapy for retinoblastoma during a 25-year period was performed. Patients who required cataract extraction with IOL placement were included. Preoperative and postoperative visual acuity and ocular complications were recorded. Results: The chart review identified 40 patients (53 eyes) with cataracts, of whom 15 (19 eyes) had surgery. Of the 19 eyes, 2 (10.5%) developed a vitreous hemorrhage (one of which was subsequently enucleated secondary to phthisis, whereas the other resolved without further complications). A total of 12 eyes (63.2%) required Nd:YAG laser capsulotomies (mean, 3.6 months; range, 1-7 months). None developed recurrence or spread of disease. Thirteen eyes (68.4%) had improved visual acuity after cataract extraction and intraocular lens placement, 4 of which (30.8%) subsequently lost vision as the result of other complications of retinoblastoma treatment. Visual acuity outcomes were 20/20 to 20/60 in 3 eyes (15.8%); 20/70 to 20/200 in 4 (21.1%); and 20/400 or less in 10 (52.6%). One patient (5.2%) required enucleation. Conclusions: Patients who underwent cataract extraction after treatment for retinoblastoma had few postoperative adverse outcomes, and visual acuity improved in most patients immediately after surgery. However, some patients who showed initial improvement subsequently lost vision as the result of other complications from retinoblastoma treatment. ( J AAPOS 2010;14:232-234)

UR - http://www.scopus.com/inward/record.url?scp=77955316178&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955316178&partnerID=8YFLogxK

U2 - 10.1016/j.jaapos.2010.01.012

DO - 10.1016/j.jaapos.2010.01.012

M3 - Article

C2 - 20399694

AN - SCOPUS:77955316178

VL - 14

SP - 232

EP - 234

JO - Journal of AAPOS

JF - Journal of AAPOS

SN - 1091-8531

IS - 3

ER -