Outcomes of Robot-assisted Partial Nephrectomy for Clinical T2 Renal Tumors: A Multicenter Analysis (ROSULA Collaborative Group)

Riccardo Bertolo, Riccardo Autorino, Giuseppe Simone, Ithaar Derweesh, Juan D. Garisto, Andrea Minervini, Daniel Eun, Sisto Perdona, James Porter, Koon Ho Rha, Alexander Mottrie, Wesley White, Luigi Schips, Bo Yang, Kenneth Jacobsohn, Robert G. Uzzo, Ben Challacombe, Matteo Ferro, Jay Sulek, Umberto CapitanioUzoma A. Anele, Gabriele Tuderti, Manuela Costantini, Stephen Ryan, Ahmet Bindayi, Andrea Mari, Marco Carini, Aryeh Keehn, Giuseppe Quarto, Michael Liao, Kidon Chang, Alessandro Larcher, Geert De Naeyer, Ottavio De Cobelli, Francesco Berardinelli, Chao Zhang, Peter Langenstroer, Alexander Kutikov, David Chen, Nicolo De Luyk, Chandru P. Sundaram, Francesco Montorsi, Robert J. Stein, Georges Pascal Haber, Lance J. Hampton, Prokar Dasgupta, Michele Gallucci, Jihad Kaouk, Francesco Porpiglia

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: While partial nephrectomy (PN) represents the standard surgical management for cT1 renal masses, its role for cT2 tumors is controversial. Robot-assisted PN (RAPN) is being increasingly implemented worldwide. Objective: To analyze perioperative, functional, and oncological outcomes of RAPN for cT2 tumors. Design, setting, and participants: Retrospective analysis of a large multicenter, multinational dataset of patients with nonmetastatic cT2 masses treated with robotic surgery (ROSULA: RObotic SUrgery for LArge renal mass). Intervention: Robotic-assisted PN. Outcome measurements and statistical analysis: Patients’ demographics, lesion characteristics, perioperative variables, renal functional data, pathology, and oncological data were analyzed. Univariable and multivariable regression analyses assessed the relationships with the risk of intra-/postoperative complications, recurrence, and survival. Results and limitations: A total of 298 patients were analyzed. Median tumor size was 7.6 (7–8.5) cm. Median RENAL score was 9 (8–10). Median ischemia time was 25 (20–32) min. Median estimated blood loss was 150 (100–300) ml. Sixteen patients had intraoperative complications (5.4%), whereas 66 (22%) had postoperative complications (5% were Clavien grade ≥3). Multivariable analysis revealed that a lower RENAL score (odds ratio [OR] 0.46, 95% confidence interval [CI] 0.21–0.65, p = 0.02) and pathological pT2 stage (OR 0.51, 95% CI 0.12–0.86, p = 0.001) were protective against postoperative complications. A total of 243 lesions (82%) were malignant. Twenty patients (8%) had positive surgical margins. Ten deaths and 25 recurrences/metastases occurred at a median follow-up of 12 (5–35) mo. At univariable analysis, higher pT stage was predictive of a likelihood of recurrences/metastases (p = 0.048). While there was a significant deterioration of renal function at discharge, this remained stable over time at 1-yr follow-up. The main limitation of this study is its retrospective design. Conclusions: RAPN in the setting of select cT2 renal masses can safely be performed with acceptable outcomes. Further studies are warranted to corroborate our findings and to better define the role of robotic nephron sparing for this challenging indication. Patient summary: This report shows that robotic surgery can be used for safe removal of a large renal tumor in a minimally invasive fashion, maximizing preservation of renal function, and without compromising cancer control.

Original languageEnglish (US)
Pages (from-to)226-232
Number of pages7
JournalEuropean Urology
Volume74
Issue number2
DOIs
StatePublished - Aug 1 2018

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Nephrectomy
Robotics
Kidney
Neoplasms
Recurrence
Odds Ratio
Confidence Intervals
Neoplasm Metastasis
Nephrons
Intraoperative Complications
Ischemia
Regression Analysis
Demography
Pathology
Survival

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Bertolo, R., Autorino, R., Simone, G., Derweesh, I., Garisto, J. D., Minervini, A., ... Porpiglia, F. (2018). Outcomes of Robot-assisted Partial Nephrectomy for Clinical T2 Renal Tumors: A Multicenter Analysis (ROSULA Collaborative Group). European Urology, 74(2), 226-232. https://doi.org/10.1016/j.eururo.2018.05.004

Outcomes of Robot-assisted Partial Nephrectomy for Clinical T2 Renal Tumors : A Multicenter Analysis (ROSULA Collaborative Group). / Bertolo, Riccardo; Autorino, Riccardo; Simone, Giuseppe; Derweesh, Ithaar; Garisto, Juan D.; Minervini, Andrea; Eun, Daniel; Perdona, Sisto; Porter, James; Rha, Koon Ho; Mottrie, Alexander; White, Wesley; Schips, Luigi; Yang, Bo; Jacobsohn, Kenneth; Uzzo, Robert G.; Challacombe, Ben; Ferro, Matteo; Sulek, Jay; Capitanio, Umberto; Anele, Uzoma A.; Tuderti, Gabriele; Costantini, Manuela; Ryan, Stephen; Bindayi, Ahmet; Mari, Andrea; Carini, Marco; Keehn, Aryeh; Quarto, Giuseppe; Liao, Michael; Chang, Kidon; Larcher, Alessandro; De Naeyer, Geert; De Cobelli, Ottavio; Berardinelli, Francesco; Zhang, Chao; Langenstroer, Peter; Kutikov, Alexander; Chen, David; De Luyk, Nicolo; Sundaram, Chandru P.; Montorsi, Francesco; Stein, Robert J.; Haber, Georges Pascal; Hampton, Lance J.; Dasgupta, Prokar; Gallucci, Michele; Kaouk, Jihad; Porpiglia, Francesco.

In: European Urology, Vol. 74, No. 2, 01.08.2018, p. 226-232.

Research output: Contribution to journalArticle

Bertolo, R, Autorino, R, Simone, G, Derweesh, I, Garisto, JD, Minervini, A, Eun, D, Perdona, S, Porter, J, Rha, KH, Mottrie, A, White, W, Schips, L, Yang, B, Jacobsohn, K, Uzzo, RG, Challacombe, B, Ferro, M, Sulek, J, Capitanio, U, Anele, UA, Tuderti, G, Costantini, M, Ryan, S, Bindayi, A, Mari, A, Carini, M, Keehn, A, Quarto, G, Liao, M, Chang, K, Larcher, A, De Naeyer, G, De Cobelli, O, Berardinelli, F, Zhang, C, Langenstroer, P, Kutikov, A, Chen, D, De Luyk, N, Sundaram, CP, Montorsi, F, Stein, RJ, Haber, GP, Hampton, LJ, Dasgupta, P, Gallucci, M, Kaouk, J & Porpiglia, F 2018, 'Outcomes of Robot-assisted Partial Nephrectomy for Clinical T2 Renal Tumors: A Multicenter Analysis (ROSULA Collaborative Group)', European Urology, vol. 74, no. 2, pp. 226-232. https://doi.org/10.1016/j.eururo.2018.05.004
Bertolo, Riccardo ; Autorino, Riccardo ; Simone, Giuseppe ; Derweesh, Ithaar ; Garisto, Juan D. ; Minervini, Andrea ; Eun, Daniel ; Perdona, Sisto ; Porter, James ; Rha, Koon Ho ; Mottrie, Alexander ; White, Wesley ; Schips, Luigi ; Yang, Bo ; Jacobsohn, Kenneth ; Uzzo, Robert G. ; Challacombe, Ben ; Ferro, Matteo ; Sulek, Jay ; Capitanio, Umberto ; Anele, Uzoma A. ; Tuderti, Gabriele ; Costantini, Manuela ; Ryan, Stephen ; Bindayi, Ahmet ; Mari, Andrea ; Carini, Marco ; Keehn, Aryeh ; Quarto, Giuseppe ; Liao, Michael ; Chang, Kidon ; Larcher, Alessandro ; De Naeyer, Geert ; De Cobelli, Ottavio ; Berardinelli, Francesco ; Zhang, Chao ; Langenstroer, Peter ; Kutikov, Alexander ; Chen, David ; De Luyk, Nicolo ; Sundaram, Chandru P. ; Montorsi, Francesco ; Stein, Robert J. ; Haber, Georges Pascal ; Hampton, Lance J. ; Dasgupta, Prokar ; Gallucci, Michele ; Kaouk, Jihad ; Porpiglia, Francesco. / Outcomes of Robot-assisted Partial Nephrectomy for Clinical T2 Renal Tumors : A Multicenter Analysis (ROSULA Collaborative Group). In: European Urology. 2018 ; Vol. 74, No. 2. pp. 226-232.
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abstract = "Background: While partial nephrectomy (PN) represents the standard surgical management for cT1 renal masses, its role for cT2 tumors is controversial. Robot-assisted PN (RAPN) is being increasingly implemented worldwide. Objective: To analyze perioperative, functional, and oncological outcomes of RAPN for cT2 tumors. Design, setting, and participants: Retrospective analysis of a large multicenter, multinational dataset of patients with nonmetastatic cT2 masses treated with robotic surgery (ROSULA: RObotic SUrgery for LArge renal mass). Intervention: Robotic-assisted PN. Outcome measurements and statistical analysis: Patients’ demographics, lesion characteristics, perioperative variables, renal functional data, pathology, and oncological data were analyzed. Univariable and multivariable regression analyses assessed the relationships with the risk of intra-/postoperative complications, recurrence, and survival. Results and limitations: A total of 298 patients were analyzed. Median tumor size was 7.6 (7–8.5) cm. Median RENAL score was 9 (8–10). Median ischemia time was 25 (20–32) min. Median estimated blood loss was 150 (100–300) ml. Sixteen patients had intraoperative complications (5.4{\%}), whereas 66 (22{\%}) had postoperative complications (5{\%} were Clavien grade ≥3). Multivariable analysis revealed that a lower RENAL score (odds ratio [OR] 0.46, 95{\%} confidence interval [CI] 0.21–0.65, p = 0.02) and pathological pT2 stage (OR 0.51, 95{\%} CI 0.12–0.86, p = 0.001) were protective against postoperative complications. A total of 243 lesions (82{\%}) were malignant. Twenty patients (8{\%}) had positive surgical margins. Ten deaths and 25 recurrences/metastases occurred at a median follow-up of 12 (5–35) mo. At univariable analysis, higher pT stage was predictive of a likelihood of recurrences/metastases (p = 0.048). While there was a significant deterioration of renal function at discharge, this remained stable over time at 1-yr follow-up. The main limitation of this study is its retrospective design. Conclusions: RAPN in the setting of select cT2 renal masses can safely be performed with acceptable outcomes. Further studies are warranted to corroborate our findings and to better define the role of robotic nephron sparing for this challenging indication. Patient summary: This report shows that robotic surgery can be used for safe removal of a large renal tumor in a minimally invasive fashion, maximizing preservation of renal function, and without compromising cancer control.",
author = "Riccardo Bertolo and Riccardo Autorino and Giuseppe Simone and Ithaar Derweesh and Garisto, {Juan D.} and Andrea Minervini and Daniel Eun and Sisto Perdona and James Porter and Rha, {Koon Ho} and Alexander Mottrie and Wesley White and Luigi Schips and Bo Yang and Kenneth Jacobsohn and Uzzo, {Robert G.} and Ben Challacombe and Matteo Ferro and Jay Sulek and Umberto Capitanio and Anele, {Uzoma A.} and Gabriele Tuderti and Manuela Costantini and Stephen Ryan and Ahmet Bindayi and Andrea Mari and Marco Carini and Aryeh Keehn and Giuseppe Quarto and Michael Liao and Kidon Chang and Alessandro Larcher and {De Naeyer}, Geert and {De Cobelli}, Ottavio and Francesco Berardinelli and Chao Zhang and Peter Langenstroer and Alexander Kutikov and David Chen and {De Luyk}, Nicolo and Sundaram, {Chandru P.} and Francesco Montorsi and Stein, {Robert J.} and Haber, {Georges Pascal} and Hampton, {Lance J.} and Prokar Dasgupta and Michele Gallucci and Jihad Kaouk and Francesco Porpiglia",
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TY - JOUR

T1 - Outcomes of Robot-assisted Partial Nephrectomy for Clinical T2 Renal Tumors

T2 - A Multicenter Analysis (ROSULA Collaborative Group)

AU - Bertolo, Riccardo

AU - Autorino, Riccardo

AU - Simone, Giuseppe

AU - Derweesh, Ithaar

AU - Garisto, Juan D.

AU - Minervini, Andrea

AU - Eun, Daniel

AU - Perdona, Sisto

AU - Porter, James

AU - Rha, Koon Ho

AU - Mottrie, Alexander

AU - White, Wesley

AU - Schips, Luigi

AU - Yang, Bo

AU - Jacobsohn, Kenneth

AU - Uzzo, Robert G.

AU - Challacombe, Ben

AU - Ferro, Matteo

AU - Sulek, Jay

AU - Capitanio, Umberto

AU - Anele, Uzoma A.

AU - Tuderti, Gabriele

AU - Costantini, Manuela

AU - Ryan, Stephen

AU - Bindayi, Ahmet

AU - Mari, Andrea

AU - Carini, Marco

AU - Keehn, Aryeh

AU - Quarto, Giuseppe

AU - Liao, Michael

AU - Chang, Kidon

AU - Larcher, Alessandro

AU - De Naeyer, Geert

AU - De Cobelli, Ottavio

AU - Berardinelli, Francesco

AU - Zhang, Chao

AU - Langenstroer, Peter

AU - Kutikov, Alexander

AU - Chen, David

AU - De Luyk, Nicolo

AU - Sundaram, Chandru P.

AU - Montorsi, Francesco

AU - Stein, Robert J.

AU - Haber, Georges Pascal

AU - Hampton, Lance J.

AU - Dasgupta, Prokar

AU - Gallucci, Michele

AU - Kaouk, Jihad

AU - Porpiglia, Francesco

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Background: While partial nephrectomy (PN) represents the standard surgical management for cT1 renal masses, its role for cT2 tumors is controversial. Robot-assisted PN (RAPN) is being increasingly implemented worldwide. Objective: To analyze perioperative, functional, and oncological outcomes of RAPN for cT2 tumors. Design, setting, and participants: Retrospective analysis of a large multicenter, multinational dataset of patients with nonmetastatic cT2 masses treated with robotic surgery (ROSULA: RObotic SUrgery for LArge renal mass). Intervention: Robotic-assisted PN. Outcome measurements and statistical analysis: Patients’ demographics, lesion characteristics, perioperative variables, renal functional data, pathology, and oncological data were analyzed. Univariable and multivariable regression analyses assessed the relationships with the risk of intra-/postoperative complications, recurrence, and survival. Results and limitations: A total of 298 patients were analyzed. Median tumor size was 7.6 (7–8.5) cm. Median RENAL score was 9 (8–10). Median ischemia time was 25 (20–32) min. Median estimated blood loss was 150 (100–300) ml. Sixteen patients had intraoperative complications (5.4%), whereas 66 (22%) had postoperative complications (5% were Clavien grade ≥3). Multivariable analysis revealed that a lower RENAL score (odds ratio [OR] 0.46, 95% confidence interval [CI] 0.21–0.65, p = 0.02) and pathological pT2 stage (OR 0.51, 95% CI 0.12–0.86, p = 0.001) were protective against postoperative complications. A total of 243 lesions (82%) were malignant. Twenty patients (8%) had positive surgical margins. Ten deaths and 25 recurrences/metastases occurred at a median follow-up of 12 (5–35) mo. At univariable analysis, higher pT stage was predictive of a likelihood of recurrences/metastases (p = 0.048). While there was a significant deterioration of renal function at discharge, this remained stable over time at 1-yr follow-up. The main limitation of this study is its retrospective design. Conclusions: RAPN in the setting of select cT2 renal masses can safely be performed with acceptable outcomes. Further studies are warranted to corroborate our findings and to better define the role of robotic nephron sparing for this challenging indication. Patient summary: This report shows that robotic surgery can be used for safe removal of a large renal tumor in a minimally invasive fashion, maximizing preservation of renal function, and without compromising cancer control.

AB - Background: While partial nephrectomy (PN) represents the standard surgical management for cT1 renal masses, its role for cT2 tumors is controversial. Robot-assisted PN (RAPN) is being increasingly implemented worldwide. Objective: To analyze perioperative, functional, and oncological outcomes of RAPN for cT2 tumors. Design, setting, and participants: Retrospective analysis of a large multicenter, multinational dataset of patients with nonmetastatic cT2 masses treated with robotic surgery (ROSULA: RObotic SUrgery for LArge renal mass). Intervention: Robotic-assisted PN. Outcome measurements and statistical analysis: Patients’ demographics, lesion characteristics, perioperative variables, renal functional data, pathology, and oncological data were analyzed. Univariable and multivariable regression analyses assessed the relationships with the risk of intra-/postoperative complications, recurrence, and survival. Results and limitations: A total of 298 patients were analyzed. Median tumor size was 7.6 (7–8.5) cm. Median RENAL score was 9 (8–10). Median ischemia time was 25 (20–32) min. Median estimated blood loss was 150 (100–300) ml. Sixteen patients had intraoperative complications (5.4%), whereas 66 (22%) had postoperative complications (5% were Clavien grade ≥3). Multivariable analysis revealed that a lower RENAL score (odds ratio [OR] 0.46, 95% confidence interval [CI] 0.21–0.65, p = 0.02) and pathological pT2 stage (OR 0.51, 95% CI 0.12–0.86, p = 0.001) were protective against postoperative complications. A total of 243 lesions (82%) were malignant. Twenty patients (8%) had positive surgical margins. Ten deaths and 25 recurrences/metastases occurred at a median follow-up of 12 (5–35) mo. At univariable analysis, higher pT stage was predictive of a likelihood of recurrences/metastases (p = 0.048). While there was a significant deterioration of renal function at discharge, this remained stable over time at 1-yr follow-up. The main limitation of this study is its retrospective design. Conclusions: RAPN in the setting of select cT2 renal masses can safely be performed with acceptable outcomes. Further studies are warranted to corroborate our findings and to better define the role of robotic nephron sparing for this challenging indication. Patient summary: This report shows that robotic surgery can be used for safe removal of a large renal tumor in a minimally invasive fashion, maximizing preservation of renal function, and without compromising cancer control.

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