Outcomes of surgical intervention for anomalous aortic origin of a coronary artery

A large contemporary prospective cohort study

Carlos M. Mery, Luis E. De León, Silvana Molossi, S. Kristen Sexson-Tejtel, Hitesh Agrawal, Rajesh Krishnamurthy, Prakash Masand, Athar M. Qureshi, E. Dean McKenzie, Charles D. Fraser

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective The purpose of this study was to prospectively analyze the outcomes of patients with anomalous aortic origin of a coronary artery undergoing surgical intervention according to a standardized management algorithm. Methods All patients aged 2 to 18 years undergoing surgical intervention for anomalous aortic origin of a coronary artery between December 2012 and April 2017 were prospectively included. Patients underwent stress nuclear perfusion imaging, stress cardiac magnetic resonance imaging, and retrospectively electrocardiogram-gated computed tomography angiography preoperatively. Patients were cleared for exercise at 3 months postoperatively if asymptomatic and repeat stress nuclear perfusion imaging, stress cardiac magnetic resonance imaging, and computed tomography angiography showed normal results. Results A total of 44 patients, with a median age of 14 years (8-18 years), underwent surgical intervention: 9 (20%) for the anomalous left coronary artery and 35 (80%) for the anomalous right coronary artery. Surgical procedures included unroofing in 35 patients (80%), translocation in 7 patients (16%), ostioplasty in 1 patient (2%), and side-side-anastomosis in 1 patient (2%). One patient who presented with aborted sudden cardiac death from an anomalous left coronary and underwent unroofing presented 1 year later with a recurrent episode and was found to have an unrecognized myocardial bridge and persistent compression of the coronary requiring reintervention. At last follow-up, 40 patients (91%) are asymptomatic and 4 patients have nonspecific chest pain; 42 patients (95%) have returned to full activity, and 2 patients are awaiting clearance. Conclusions Surgical treatment for anomalous aortic origin of a coronary artery is safe and should aim to associate the coronary ostium with the correct sinus, away from the intercoronary pillar. After surgery, the majority of patients are cleared for exercise and remain asymptomatic. Longer follow-up is needed to assess the true efficacy of surgery in the prevention of sudden cardiac death.

Original languageEnglish (US)
Pages (from-to)305-319.e4
JournalJournal of Thoracic and Cardiovascular Surgery
Volume155
Issue number1
DOIs
StatePublished - Jan 1 2018

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Coronary Vessels
Cohort Studies
Prospective Studies
Perfusion Imaging
Sudden Cardiac Death
Magnetic Resonance Imaging
Exercise
Chest Pain
Electrocardiography

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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Outcomes of surgical intervention for anomalous aortic origin of a coronary artery : A large contemporary prospective cohort study. / Mery, Carlos M.; De León, Luis E.; Molossi, Silvana; Sexson-Tejtel, S. Kristen; Agrawal, Hitesh; Krishnamurthy, Rajesh; Masand, Prakash; Qureshi, Athar M.; McKenzie, E. Dean; Fraser, Charles D.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 155, No. 1, 01.01.2018, p. 305-319.e4.

Research output: Contribution to journalArticle

Mery, CM, De León, LE, Molossi, S, Sexson-Tejtel, SK, Agrawal, H, Krishnamurthy, R, Masand, P, Qureshi, AM, McKenzie, ED & Fraser, CD 2018, 'Outcomes of surgical intervention for anomalous aortic origin of a coronary artery: A large contemporary prospective cohort study', Journal of Thoracic and Cardiovascular Surgery, vol. 155, no. 1, pp. 305-319.e4. https://doi.org/10.1016/j.jtcvs.2017.08.116
Mery, Carlos M. ; De León, Luis E. ; Molossi, Silvana ; Sexson-Tejtel, S. Kristen ; Agrawal, Hitesh ; Krishnamurthy, Rajesh ; Masand, Prakash ; Qureshi, Athar M. ; McKenzie, E. Dean ; Fraser, Charles D. / Outcomes of surgical intervention for anomalous aortic origin of a coronary artery : A large contemporary prospective cohort study. In: Journal of Thoracic and Cardiovascular Surgery. 2018 ; Vol. 155, No. 1. pp. 305-319.e4.
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abstract = "Objective The purpose of this study was to prospectively analyze the outcomes of patients with anomalous aortic origin of a coronary artery undergoing surgical intervention according to a standardized management algorithm. Methods All patients aged 2 to 18 years undergoing surgical intervention for anomalous aortic origin of a coronary artery between December 2012 and April 2017 were prospectively included. Patients underwent stress nuclear perfusion imaging, stress cardiac magnetic resonance imaging, and retrospectively electrocardiogram-gated computed tomography angiography preoperatively. Patients were cleared for exercise at 3 months postoperatively if asymptomatic and repeat stress nuclear perfusion imaging, stress cardiac magnetic resonance imaging, and computed tomography angiography showed normal results. Results A total of 44 patients, with a median age of 14 years (8-18 years), underwent surgical intervention: 9 (20{\%}) for the anomalous left coronary artery and 35 (80{\%}) for the anomalous right coronary artery. Surgical procedures included unroofing in 35 patients (80{\%}), translocation in 7 patients (16{\%}), ostioplasty in 1 patient (2{\%}), and side-side-anastomosis in 1 patient (2{\%}). One patient who presented with aborted sudden cardiac death from an anomalous left coronary and underwent unroofing presented 1 year later with a recurrent episode and was found to have an unrecognized myocardial bridge and persistent compression of the coronary requiring reintervention. At last follow-up, 40 patients (91{\%}) are asymptomatic and 4 patients have nonspecific chest pain; 42 patients (95{\%}) have returned to full activity, and 2 patients are awaiting clearance. Conclusions Surgical treatment for anomalous aortic origin of a coronary artery is safe and should aim to associate the coronary ostium with the correct sinus, away from the intercoronary pillar. After surgery, the majority of patients are cleared for exercise and remain asymptomatic. Longer follow-up is needed to assess the true efficacy of surgery in the prevention of sudden cardiac death.",
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T1 - Outcomes of surgical intervention for anomalous aortic origin of a coronary artery

T2 - A large contemporary prospective cohort study

AU - Mery, Carlos M.

AU - De León, Luis E.

AU - Molossi, Silvana

AU - Sexson-Tejtel, S. Kristen

AU - Agrawal, Hitesh

AU - Krishnamurthy, Rajesh

AU - Masand, Prakash

AU - Qureshi, Athar M.

AU - McKenzie, E. Dean

AU - Fraser, Charles D.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective The purpose of this study was to prospectively analyze the outcomes of patients with anomalous aortic origin of a coronary artery undergoing surgical intervention according to a standardized management algorithm. Methods All patients aged 2 to 18 years undergoing surgical intervention for anomalous aortic origin of a coronary artery between December 2012 and April 2017 were prospectively included. Patients underwent stress nuclear perfusion imaging, stress cardiac magnetic resonance imaging, and retrospectively electrocardiogram-gated computed tomography angiography preoperatively. Patients were cleared for exercise at 3 months postoperatively if asymptomatic and repeat stress nuclear perfusion imaging, stress cardiac magnetic resonance imaging, and computed tomography angiography showed normal results. Results A total of 44 patients, with a median age of 14 years (8-18 years), underwent surgical intervention: 9 (20%) for the anomalous left coronary artery and 35 (80%) for the anomalous right coronary artery. Surgical procedures included unroofing in 35 patients (80%), translocation in 7 patients (16%), ostioplasty in 1 patient (2%), and side-side-anastomosis in 1 patient (2%). One patient who presented with aborted sudden cardiac death from an anomalous left coronary and underwent unroofing presented 1 year later with a recurrent episode and was found to have an unrecognized myocardial bridge and persistent compression of the coronary requiring reintervention. At last follow-up, 40 patients (91%) are asymptomatic and 4 patients have nonspecific chest pain; 42 patients (95%) have returned to full activity, and 2 patients are awaiting clearance. Conclusions Surgical treatment for anomalous aortic origin of a coronary artery is safe and should aim to associate the coronary ostium with the correct sinus, away from the intercoronary pillar. After surgery, the majority of patients are cleared for exercise and remain asymptomatic. Longer follow-up is needed to assess the true efficacy of surgery in the prevention of sudden cardiac death.

AB - Objective The purpose of this study was to prospectively analyze the outcomes of patients with anomalous aortic origin of a coronary artery undergoing surgical intervention according to a standardized management algorithm. Methods All patients aged 2 to 18 years undergoing surgical intervention for anomalous aortic origin of a coronary artery between December 2012 and April 2017 were prospectively included. Patients underwent stress nuclear perfusion imaging, stress cardiac magnetic resonance imaging, and retrospectively electrocardiogram-gated computed tomography angiography preoperatively. Patients were cleared for exercise at 3 months postoperatively if asymptomatic and repeat stress nuclear perfusion imaging, stress cardiac magnetic resonance imaging, and computed tomography angiography showed normal results. Results A total of 44 patients, with a median age of 14 years (8-18 years), underwent surgical intervention: 9 (20%) for the anomalous left coronary artery and 35 (80%) for the anomalous right coronary artery. Surgical procedures included unroofing in 35 patients (80%), translocation in 7 patients (16%), ostioplasty in 1 patient (2%), and side-side-anastomosis in 1 patient (2%). One patient who presented with aborted sudden cardiac death from an anomalous left coronary and underwent unroofing presented 1 year later with a recurrent episode and was found to have an unrecognized myocardial bridge and persistent compression of the coronary requiring reintervention. At last follow-up, 40 patients (91%) are asymptomatic and 4 patients have nonspecific chest pain; 42 patients (95%) have returned to full activity, and 2 patients are awaiting clearance. Conclusions Surgical treatment for anomalous aortic origin of a coronary artery is safe and should aim to associate the coronary ostium with the correct sinus, away from the intercoronary pillar. After surgery, the majority of patients are cleared for exercise and remain asymptomatic. Longer follow-up is needed to assess the true efficacy of surgery in the prevention of sudden cardiac death.

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DO - 10.1016/j.jtcvs.2017.08.116

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