Ovarian function’s role during cancer cachexia progression in the female mouse

Kimbell L. Hetzler, Justin P. Hardee, Holly A. Lavoie, E. Angela Murphy, James Carson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cachexia is a debilitating condition that occurs with chronic disease, including cancer; our research has shown that some regulation of cancer cachexia progression is affected by sex differences. The Apc Min/+ mouse is genetically predisposed to develop intestinal tumors; IL-6 signaling and hypogonadism are associated with cachexia severity in the male. This relationship in the female warrants further investigation, as we have shown that the ability of IL-6 to induce cachexia differs between the sexes. Since ovarian reproductive function relies on a complex system of endocrine signaling to affect whole body homeostasis, we examined the relationship between ovarian reproductive function and progression of cancer cachexia in the female Apc Min/+ mouse. Our study of ovarian reproductive function in female Apc Min/+ mice showed disease-related cessation of estrous cycling (acyclicity) in 38% of mice. Acyclicity, including morphological and functional losses and enhanced muscle inflammatory gene expression, was associated with severe cachexia. Interestingly, ovariectomy rescued body weight and muscle mass and function but increased muscle sensitivity to systemic IL-6 overexpression. In conclusion, our results provide evidence for a relationship between ovarian reproductive function and cachexia progression in female Apc Min/+ mice.

Original languageEnglish (US)
Pages (from-to)E447-E459
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume312
Issue number5
DOIs
StatePublished - May 15 2017

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Cachexia
Neoplasms
Interleukin-6
Muscles
Endocrine System
Hypogonadism
Ovariectomy
Sex Characteristics
Homeostasis
Chronic Disease
Body Weight
Gene Expression
Research

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

Cite this

Ovarian function’s role during cancer cachexia progression in the female mouse. / Hetzler, Kimbell L.; Hardee, Justin P.; Lavoie, Holly A.; Murphy, E. Angela; Carson, James.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 312, No. 5, 15.05.2017, p. E447-E459.

Research output: Contribution to journalArticle

Hetzler, Kimbell L. ; Hardee, Justin P. ; Lavoie, Holly A. ; Murphy, E. Angela ; Carson, James. / Ovarian function’s role during cancer cachexia progression in the female mouse. In: American Journal of Physiology - Endocrinology and Metabolism. 2017 ; Vol. 312, No. 5. pp. E447-E459.
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