Overlapping representation of primary tastes in a defined region of the gustatory cortex

Max Fletcher, M. Cameron Ogg, Lianyi Lu, Robert J. Ogg, John Boughter

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Both physiological and imaging approaches have led to often-disparate conclusions about the organization of taste information in gustatory cortex (GC). In this study, we used neuroanatomical and imaging approaches to delineate the likely area of insular cortex given to gustatory function and to characterize taste responses within this delineated area in female and male C57BL/6J mice. Anterograde tracers were injected into the taste thalamus (the medial parvicellular portion of the ventral posterior medial division, VPMpc) of mice and the thalamic terminal field was investigated across the cortex. Working within the delineated area, we used two-photon imaging to measure basic taste responses in >780 neurons in layer 2/3 located just posterior to the middle cerebral artery. A nonbiased, hierarchical cluster analysis revealed multiple clusters of cells responding best to either individual or combinations of taste stimuli. Taste quality was represented in the activity of taste-responsive cells; however, there was no apparent spatial organization of primary taste qualities in this region.

Original languageEnglish (US)
Pages (from-to)7595-7605
Number of pages11
JournalJournal of Neuroscience
Volume37
Issue number32
DOIs
StatePublished - Jan 1 2017

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Middle Cerebral Artery
Thalamus
Inbred C57BL Mouse
Photons
Cerebral Cortex
Cluster Analysis
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Overlapping representation of primary tastes in a defined region of the gustatory cortex. / Fletcher, Max; Ogg, M. Cameron; Lu, Lianyi; Ogg, Robert J.; Boughter, John.

In: Journal of Neuroscience, Vol. 37, No. 32, 01.01.2017, p. 7595-7605.

Research output: Contribution to journalArticle

Fletcher, Max ; Ogg, M. Cameron ; Lu, Lianyi ; Ogg, Robert J. ; Boughter, John. / Overlapping representation of primary tastes in a defined region of the gustatory cortex. In: Journal of Neuroscience. 2017 ; Vol. 37, No. 32. pp. 7595-7605.
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