Overload-induced androgen receptor expression in the aged rat hindlimb receiving nandrolone decanoate

Won Jun Lee, Joseph McClung, G. A. Hand, James Carson

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

This study's purpose was to examine whether functional overload with nandrolone decanoate (ND) administration increased muscle mass and steroid receptor concentration in aged rat soleus (Sol) and plantaris (Plan) muscle. ND (6 mg/kg body wt) was administered once a week for 4 wk, whereas control rats received sesame seed oil injections. Functional overload of the hindlimb Sol and Plan was induced by synergistic gastrocnemius muscle ablation at the beginning of the fourth week. Adult (5 mo of age) and aged rats (25 mo of age) were randomly assigned to four groups: control, overload, control-ND, and overload-ND. Seven days of functional overload increased adult Sol muscle mass 27%, whereas the aged Sol muscle mass did not change. The aged overloaded Sol muscle receiving ND significantly increased muscle weight by 35% and total muscle protein by 24%. Aged Plan muscle did not increase muscle weight with overload or ND treatment. Androgen receptor protein was induced by ND treatment and functional Ov, and combining the two treatments induced Sol androgen receptor protein concentration above either alone. Sol glucocorticoid receptor protein concentration increased in overload groups of both ages. ND administration can increase aged Sol muscle mass and protein content after 7 days of functional overload, and the cooperative induction of androgen receptor may be important for this response.

Original languageEnglish (US)
Pages (from-to)1153-1161
Number of pages9
JournalJournal of Applied Physiology
Volume94
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

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Androgen Receptors
Hindlimb
Skeletal Muscle
Muscle Proteins
Muscles
Sesame Oil
Weights and Measures
Proteins
nandrolone decanoate
Steroid Receptors
Glucocorticoid Receptors
Seeds
Therapeutics
Age Groups
Control Groups
Injections

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Overload-induced androgen receptor expression in the aged rat hindlimb receiving nandrolone decanoate. / Lee, Won Jun; McClung, Joseph; Hand, G. A.; Carson, James.

In: Journal of Applied Physiology, Vol. 94, No. 3, 01.03.2003, p. 1153-1161.

Research output: Contribution to journalArticle

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