Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia

Lack of the therapeutic role of local irradiation

Nobuko Hijiya, W. Liu, I. T. Sandlund, S. Jeha, B. I. Razzouk, R. C. Ribeiro, J. E. Rubnitz, Scott Howard, E. P. Kyzer, D. S. Redd, C. Cheng, G. K. Rivera, M. M. Hudson, M. V. Relling, C. H. Pui

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

To assess the prognosis of overt testicular disease at diagnosis of acute lymphoblastic leukemia, and any therapeutic role of irradiation for this involvement, we reviewed the data of 811 boys treated on St Jude studies Total X-XI (early period) and Total XII-XIV (recent period). In all, 19 boys (2.3%) had testicular disease at diagnosis. In the early period, patients with testicular leukemia had a poorer overall survival (OS) (P=0.003), event-free survival (EFS) (P=0.064), and higher cumulative incidence of relapse (P=0.041) than did other patients. During the recent period, patients with and without overt testicular leukemia did not differ in OS (P=0.257), EFS (P=0.102), or cumulative incidence of relapse (P=0.51). In a multivariate analysis, OS was lower for patients with testicular disease than for those without the involvement in the early period (P=0.047) but not in the recent one (P=0.75). Both patients who received irradiation for residual testicular disease at the end of induction subsequently died of leukemia. Of the other 17 patients who did not receive irradiation, only one developed testicular relapse in combination with bone marrow relapse. In conclusion, the prognostic impact of overt testicular disease has diminished. Irradiation appears to provide no survival advantage to this patient population.

Original languageEnglish (US)
Pages (from-to)1399-1403
Number of pages5
JournalLeukemia
Volume19
Issue number8
DOIs
StatePublished - Jan 1 2005

Fingerprint

Testicular Diseases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Recurrence
Leukemia
Survival
Therapeutics
Disease-Free Survival
Incidence
Multivariate Analysis
Bone Marrow

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Hijiya, N., Liu, W., Sandlund, I. T., Jeha, S., Razzouk, B. I., Ribeiro, R. C., ... Pui, C. H. (2005). Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia: Lack of the therapeutic role of local irradiation. Leukemia, 19(8), 1399-1403. https://doi.org/10.1038/sj.leu.2403843

Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia : Lack of the therapeutic role of local irradiation. / Hijiya, Nobuko; Liu, W.; Sandlund, I. T.; Jeha, S.; Razzouk, B. I.; Ribeiro, R. C.; Rubnitz, J. E.; Howard, Scott; Kyzer, E. P.; Redd, D. S.; Cheng, C.; Rivera, G. K.; Hudson, M. M.; Relling, M. V.; Pui, C. H.

In: Leukemia, Vol. 19, No. 8, 01.01.2005, p. 1399-1403.

Research output: Contribution to journalReview article

Hijiya, N, Liu, W, Sandlund, IT, Jeha, S, Razzouk, BI, Ribeiro, RC, Rubnitz, JE, Howard, S, Kyzer, EP, Redd, DS, Cheng, C, Rivera, GK, Hudson, MM, Relling, MV & Pui, CH 2005, 'Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia: Lack of the therapeutic role of local irradiation', Leukemia, vol. 19, no. 8, pp. 1399-1403. https://doi.org/10.1038/sj.leu.2403843
Hijiya, Nobuko ; Liu, W. ; Sandlund, I. T. ; Jeha, S. ; Razzouk, B. I. ; Ribeiro, R. C. ; Rubnitz, J. E. ; Howard, Scott ; Kyzer, E. P. ; Redd, D. S. ; Cheng, C. ; Rivera, G. K. ; Hudson, M. M. ; Relling, M. V. ; Pui, C. H. / Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia : Lack of the therapeutic role of local irradiation. In: Leukemia. 2005 ; Vol. 19, No. 8. pp. 1399-1403.
@article{d48feb920cda4e688cf5f7e586ae5a3e,
title = "Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia: Lack of the therapeutic role of local irradiation",
abstract = "To assess the prognosis of overt testicular disease at diagnosis of acute lymphoblastic leukemia, and any therapeutic role of irradiation for this involvement, we reviewed the data of 811 boys treated on St Jude studies Total X-XI (early period) and Total XII-XIV (recent period). In all, 19 boys (2.3{\%}) had testicular disease at diagnosis. In the early period, patients with testicular leukemia had a poorer overall survival (OS) (P=0.003), event-free survival (EFS) (P=0.064), and higher cumulative incidence of relapse (P=0.041) than did other patients. During the recent period, patients with and without overt testicular leukemia did not differ in OS (P=0.257), EFS (P=0.102), or cumulative incidence of relapse (P=0.51). In a multivariate analysis, OS was lower for patients with testicular disease than for those without the involvement in the early period (P=0.047) but not in the recent one (P=0.75). Both patients who received irradiation for residual testicular disease at the end of induction subsequently died of leukemia. Of the other 17 patients who did not receive irradiation, only one developed testicular relapse in combination with bone marrow relapse. In conclusion, the prognostic impact of overt testicular disease has diminished. Irradiation appears to provide no survival advantage to this patient population.",
author = "Nobuko Hijiya and W. Liu and Sandlund, {I. T.} and S. Jeha and Razzouk, {B. I.} and Ribeiro, {R. C.} and Rubnitz, {J. E.} and Scott Howard and Kyzer, {E. P.} and Redd, {D. S.} and C. Cheng and Rivera, {G. K.} and Hudson, {M. M.} and Relling, {M. V.} and Pui, {C. H.}",
year = "2005",
month = "1",
day = "1",
doi = "10.1038/sj.leu.2403843",
language = "English (US)",
volume = "19",
pages = "1399--1403",
journal = "Leukemia",
issn = "0887-6924",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia

T2 - Lack of the therapeutic role of local irradiation

AU - Hijiya, Nobuko

AU - Liu, W.

AU - Sandlund, I. T.

AU - Jeha, S.

AU - Razzouk, B. I.

AU - Ribeiro, R. C.

AU - Rubnitz, J. E.

AU - Howard, Scott

AU - Kyzer, E. P.

AU - Redd, D. S.

AU - Cheng, C.

AU - Rivera, G. K.

AU - Hudson, M. M.

AU - Relling, M. V.

AU - Pui, C. H.

PY - 2005/1/1

Y1 - 2005/1/1

N2 - To assess the prognosis of overt testicular disease at diagnosis of acute lymphoblastic leukemia, and any therapeutic role of irradiation for this involvement, we reviewed the data of 811 boys treated on St Jude studies Total X-XI (early period) and Total XII-XIV (recent period). In all, 19 boys (2.3%) had testicular disease at diagnosis. In the early period, patients with testicular leukemia had a poorer overall survival (OS) (P=0.003), event-free survival (EFS) (P=0.064), and higher cumulative incidence of relapse (P=0.041) than did other patients. During the recent period, patients with and without overt testicular leukemia did not differ in OS (P=0.257), EFS (P=0.102), or cumulative incidence of relapse (P=0.51). In a multivariate analysis, OS was lower for patients with testicular disease than for those without the involvement in the early period (P=0.047) but not in the recent one (P=0.75). Both patients who received irradiation for residual testicular disease at the end of induction subsequently died of leukemia. Of the other 17 patients who did not receive irradiation, only one developed testicular relapse in combination with bone marrow relapse. In conclusion, the prognostic impact of overt testicular disease has diminished. Irradiation appears to provide no survival advantage to this patient population.

AB - To assess the prognosis of overt testicular disease at diagnosis of acute lymphoblastic leukemia, and any therapeutic role of irradiation for this involvement, we reviewed the data of 811 boys treated on St Jude studies Total X-XI (early period) and Total XII-XIV (recent period). In all, 19 boys (2.3%) had testicular disease at diagnosis. In the early period, patients with testicular leukemia had a poorer overall survival (OS) (P=0.003), event-free survival (EFS) (P=0.064), and higher cumulative incidence of relapse (P=0.041) than did other patients. During the recent period, patients with and without overt testicular leukemia did not differ in OS (P=0.257), EFS (P=0.102), or cumulative incidence of relapse (P=0.51). In a multivariate analysis, OS was lower for patients with testicular disease than for those without the involvement in the early period (P=0.047) but not in the recent one (P=0.75). Both patients who received irradiation for residual testicular disease at the end of induction subsequently died of leukemia. Of the other 17 patients who did not receive irradiation, only one developed testicular relapse in combination with bone marrow relapse. In conclusion, the prognostic impact of overt testicular disease has diminished. Irradiation appears to provide no survival advantage to this patient population.

UR - http://www.scopus.com/inward/record.url?scp=23744467501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23744467501&partnerID=8YFLogxK

U2 - 10.1038/sj.leu.2403843

DO - 10.1038/sj.leu.2403843

M3 - Review article

VL - 19

SP - 1399

EP - 1403

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 8

ER -