Overweight and obesity over the adult life course and incident mobility limitation in older adults

The health, aging and body composition study

Denise K. Houston, Jingzhong Ding, Barbara J. Nicklas, Tamara B. Harris, Jung Sun Lee, Michael C. Nevitt, Susan M. Rubin, Frances Tylavsky, Stephen B. Kritchevsky

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Obesity in middle and old age predicts mobility limitation; however, the cumulative effect of overweight and/or obesity over the adult life course is unknown. The association between overweight and/or obesity in young, middle, and late adulthood and its cumulative effect on incident mobility limitation was examined among community-dwelling US adults aged 70-79 years at baseline (1997-1998) in the Health, Aging and Body Composition Study (n=2,845). Body mass index was calculated by using recalled weight at ages 25 and 50 years and measured weight at ages 70-79 years. Mobility limitation (difficulty walking 1/4 mile (0.4 km) or climbing 10 steps) was assessed semiannually over 7 years of follow-up and was reported by 43.0% of men and 53.7% of women. Men and women who were overweight or obese at all 3 time points had an increased risk of mobility limitation (hazard ratio=1.61, 95% confidence interval: 1.25, 2.06 and hazard ratio=2.85, 95% confidence interval: 2.15, 3.78, respectively) compared with those who were normal weight throughout. Furthermore, there was a significant graded response (P<0.0001) on risk of mobility limitation for the cumulative effect of obesity in men and overweight and/or obesity in women. Onset of overweight and obesity in earlier life contributes to an increased risk of mobility limitation in old age.

Original languageEnglish (US)
Pages (from-to)927-936
Number of pages10
JournalAmerican Journal of Epidemiology
Volume169
Issue number8
DOIs
StatePublished - Apr 2009

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Mobility Limitation
Body Composition
Obesity
Health
Weights and Measures
Confidence Intervals
Independent Living
Body Mass Index

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Overweight and obesity over the adult life course and incident mobility limitation in older adults : The health, aging and body composition study. / Houston, Denise K.; Ding, Jingzhong; Nicklas, Barbara J.; Harris, Tamara B.; Lee, Jung Sun; Nevitt, Michael C.; Rubin, Susan M.; Tylavsky, Frances; Kritchevsky, Stephen B.

In: American Journal of Epidemiology, Vol. 169, No. 8, 04.2009, p. 927-936.

Research output: Contribution to journalArticle

Houston, Denise K. ; Ding, Jingzhong ; Nicklas, Barbara J. ; Harris, Tamara B. ; Lee, Jung Sun ; Nevitt, Michael C. ; Rubin, Susan M. ; Tylavsky, Frances ; Kritchevsky, Stephen B. / Overweight and obesity over the adult life course and incident mobility limitation in older adults : The health, aging and body composition study. In: American Journal of Epidemiology. 2009 ; Vol. 169, No. 8. pp. 927-936.
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