Oxidation and mitochondrial origin of NET DNA in the pathogenesis of lupus

Sylviane Muller, Marko Radic

Research output: Contribution to journalShort survey

9 Citations (Scopus)

Abstract

A new study of the pathogenesis of systemic lupus erythematosus (SLE) highlights the importance of mitochondria and mitochondrial reactive oxygen species (ROS) in the generation of neutrophil extracellular traps (NETs) that have the enhanced potential to elicit interferon-induced gene expression.

Original languageEnglish (US)
Pages (from-to)126-127
Number of pages2
JournalNature Medicine
Volume22
Issue number2
DOIs
StatePublished - Feb 4 2016

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Mitochondria
Gene expression
Systemic Lupus Erythematosus
Interferons
Reactive Oxygen Species
Gene Expression
Oxidation
DNA
Extracellular Traps

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Oxidation and mitochondrial origin of NET DNA in the pathogenesis of lupus. / Muller, Sylviane; Radic, Marko.

In: Nature Medicine, Vol. 22, No. 2, 04.02.2016, p. 126-127.

Research output: Contribution to journalShort survey

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