Oxidative stress and cardiac repair/remodeling following infarction

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

Extensive cardiac remodeling after myocardial infarction (MI) contributes significantly to ventricular dysfunction. Factors regulating left ventricular remodeling at different stages after MI are under investigation. There is growing recognition and experimental evidence that oxidative stress mediated by reactive oxygen species plays a role in the pathogeneses of myocardial repair/remodeling in various cardiac diseases. After acute MI, oxidative stress is developed in both infarcted and noninfarcted myocardium. Accumulating evidence has demonstrated that oxidative stress participates in several aspects of cardiac repair/remodeling after infarction that include cardiomyocyte apoptosis, inflammatory/fibrogenic responses, and hypertrophy. The exact pathways on reactive oxygen species-mediated myocardial remodeling are under investigation. The therapeutic potential of oxidative stress-directed drugs in myocardial remodeling after infarction has not been fully realized.

Original languageEnglish (US)
Pages (from-to)197-205
Number of pages9
JournalAmerican Journal of the Medical Sciences
Volume334
Issue number3
DOIs
StatePublished - Jan 1 2007

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Infarction
Oxidative Stress
Myocardial Infarction
Reactive Oxygen Species
Ventricular Dysfunction
Ventricular Remodeling
Cardiac Myocytes
Hypertrophy
Heart Diseases
Myocardium
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Oxidative stress and cardiac repair/remodeling following infarction. / Sun, Yao.

In: American Journal of the Medical Sciences, Vol. 334, No. 3, 01.01.2007, p. 197-205.

Research output: Contribution to journalReview article

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