Oxidative stress in cardiac repair and remodeling: Molecular pathways and therapeutic strategies

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cardiac remodeling occurs in a variety of heart diseases, contributing to ventricular dysfunction. Following myocardial infarction (MI), cardiac repair and remodeling appear in both infarcted and non-infarcted myocardium. Factors regulating cardiac repair/remodeling at different stages following MI are under investigation. There is growing recognition and experimental evidence that oxidative stress mediated by reactive oxygen species (ROS) plays a role in the pathogeneses of myocardial repair/remodeling in various cardiac diseases. After acute MI, oxidative stress is developed in both infarcted and non-infarcted myocardium. Accumulating evidence has demonstrated that ROS participates in several aspects of cardiac repair/ remodeling following infarction that includes cardiomyocyte apoptosis, inflammatory/fibrogenic responses, hypertrophy, and angiogenesis. The exact pathways on ROS-mediated myocardial remodeling are under investigation. The therapeutic potential of oxidative stress-directed drugs in myocardial remodeling following infarction has not been fully realized.

Original languageEnglish (US)
Title of host publicationCardiac Remodeling
Subtitle of host publicationMolecular Mechanisms
PublisherSpringer New York
Pages413-425
Number of pages13
ISBN (Electronic)9781461459309
ISBN (Print)9781461459293
DOIs
StatePublished - Jan 1 2013

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Oxidative stress
Reactive Oxygen Species
Oxidative Stress
Repair
Myocardial Infarction
Infarction
Heart Diseases
Myocardium
Ventricular Dysfunction
Cardiac Myocytes
Hypertrophy
Therapeutics
Apoptosis
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Oxidative stress in cardiac repair and remodeling : Molecular pathways and therapeutic strategies. / Sun, Yao.

Cardiac Remodeling: Molecular Mechanisms. Springer New York, 2013. p. 413-425.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sun, Yao. / Oxidative stress in cardiac repair and remodeling : Molecular pathways and therapeutic strategies. Cardiac Remodeling: Molecular Mechanisms. Springer New York, 2013. pp. 413-425
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