Oxidative stress is associated with weight gain in recipients at 12-months following kidney transplantation

Young Eun Cho, Hyung Suk Kim, Chen Lai, Ansley Stanfill, Ann Cashion

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Weight gain after kidney transplantation (Tx) is considered a risk factor for poor outcomes. Increased oxidative stress is associated with not only chronic renal disease and Tx, but also obesity and cardiovascular disease. The aim of this pilot study was to test whether oxidative stress is related to weight gain at 12-months after kidney Tx and to obtain preliminary insight into potential mechanisms involved. Design & methods: Recipients (n = 33) were classified into two groups; weight loss and weight gain, based on their weight changes at 12-months post-transplant. Total antioxidant capacity (TAOC) and lipid peroxidation (TBARS) were measured to evaluate oxidative stress from plasma at baseline and 12-months. A secondary data analysis was conducted to identify potential gene regulation. Results: Seventeen recipients lost (- 6.63 ± 5.52 kg), and sixteen recipients gained weight (8.94 ± 6.18 kg). TAOC was significantly decreased at 12-months compared to baseline for the total group, however, there was no significant difference between groups at either time point. TBARS was higher in weight gain group, at both time points, and it was significantly higher at 12-months (p = 0.012). Gene expression profiling analysis showed that 7 transcripts annotated to reactive oxygen species related genes in adipose tissue were expressed significantly lower in weight gain group at baseline, which might be a negative feedback mechanism to reduce oxidative stress. Conclusion: These results may indicate that elevated oxidative stress (TBARS) is associated with weight gain after kidney Tx and that incorporating early clinical prevention strategies known to decrease oxidative stress could be recommended.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalClinical Biochemistry
Volume49
Issue number3
DOIs
StatePublished - Feb 1 2016

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Oxidative stress
Kidney Transplantation
Weight Gain
Oxidative Stress
Gene expression
Antioxidants
Kidney
Weights and Measures
Transplants
Gene Expression Profiling
Chronic Renal Insufficiency
Lipid Peroxidation
Genes
Adipose Tissue
Weight Loss
Reactive Oxygen Species
Cardiovascular Diseases
Obesity
Tissue
Feedback

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

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Oxidative stress is associated with weight gain in recipients at 12-months following kidney transplantation. / Cho, Young Eun; Kim, Hyung Suk; Lai, Chen; Stanfill, Ansley; Cashion, Ann.

In: Clinical Biochemistry, Vol. 49, No. 3, 01.02.2016, p. 237-242.

Research output: Contribution to journalArticle

Cho, Young Eun ; Kim, Hyung Suk ; Lai, Chen ; Stanfill, Ansley ; Cashion, Ann. / Oxidative stress is associated with weight gain in recipients at 12-months following kidney transplantation. In: Clinical Biochemistry. 2016 ; Vol. 49, No. 3. pp. 237-242.
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