Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer

Daniel A. Barocas, Saundra Motley, Michael S. Cookson, Sam S. Chang, David F. Penson, Qi Dai, Ginger Milne, L. Jackson Roberts, Jason Morrow, Raoul S. Concepcion, Joseph A. Smith, Jay Fowke

Research output: Contribution to journalArticle

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Abstract

Purpose: Oxidative stress is implicated in prostate cancer by several lines of evidence. We studied the relationship between the level of F2-isoprostanes, a validated biomarker of oxidative stress, and prostate cancer and high grade prostatic intraepithelial neoplasia. Materials and Methods: This case-control analysis within the Nashville Men's Health Study included men recruited at prostate biopsy. Body morphometrics, health history and urine were collected from more than 2,000 men before biopsy. F2-isoprostanes were measured by gas chromatography/mass spectrometry within an age matched sample of Nashville Men's Health Study participants that included 140 patients with high grade prostatic intraepithelial neoplasia, 160 biopsy negative controls and 200 prostate cancer cases. Multivariable linear and logistic regression was used to determine the associations between F2-isoprostane level, and high grade prostatic intraepithelial neoplasia and prostate cancer. Results: Mean patient age was 66.9 years (SD 7.2) and 10.1% were nonwhite. Adjusted geometric mean F2-isoprostane levels were higher in patients with prostate cancer (1.82, 95% CI 1.662.00) or high grade prostatic intraepithelial neoplasia (1.82, 95% CI 1.681.96) than in controls (1.63, 95% CI 1.491.78, p <0.001), but were similar across Gleason scores (p = 0.511). The adjusted odds of high grade prostatic intraepithelial neoplasia and prostate cancer increased with increasing F2-isoprostane quartile (p-trend = 0.015 and 0.047, respectively) and the highest F2-isoprostane quartile was associated with significantly increased odds of prostate cancer (OR 2.44, 95% CI 1.175.09, p = 0.017). Conclusions: Pre-diagnosis urine F2-isoprostane level is increased in men with high grade prostatic intraepithelial neoplasia or prostate cancer, suggesting urinary F2-isoprostane provides a biomarker for the role for oxidative stress in prostate carcinogenesis. F2-isoprostanes may also serve to estimate the efficacy of interventions targeting oxidative stress mechanisms in prostate cancer prevention or treatment.

Original languageEnglish (US)
Pages (from-to)2102-2107
Number of pages6
JournalJournal of Urology
Volume185
Issue number6
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

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F2-Isoprostanes
Prostatic Intraepithelial Neoplasia
Prostatic Neoplasms
Oxidative Stress
Urine
Men's Health
Biopsy
Prostate
Biomarkers
Neoplasm Grading
Gas Chromatography-Mass Spectrometry
Linear Models
Carcinogenesis
Logistic Models

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Barocas, D. A., Motley, S., Cookson, M. S., Chang, S. S., Penson, D. F., Dai, Q., ... Fowke, J. (2011). Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer. Journal of Urology, 185(6), 2102-2107. https://doi.org/10.1016/j.juro.2011.02.020

Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer. / Barocas, Daniel A.; Motley, Saundra; Cookson, Michael S.; Chang, Sam S.; Penson, David F.; Dai, Qi; Milne, Ginger; Roberts, L. Jackson; Morrow, Jason; Concepcion, Raoul S.; Smith, Joseph A.; Fowke, Jay.

In: Journal of Urology, Vol. 185, No. 6, 01.06.2011, p. 2102-2107.

Research output: Contribution to journalArticle

Barocas, DA, Motley, S, Cookson, MS, Chang, SS, Penson, DF, Dai, Q, Milne, G, Roberts, LJ, Morrow, J, Concepcion, RS, Smith, JA & Fowke, J 2011, 'Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer', Journal of Urology, vol. 185, no. 6, pp. 2102-2107. https://doi.org/10.1016/j.juro.2011.02.020
Barocas DA, Motley S, Cookson MS, Chang SS, Penson DF, Dai Q et al. Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer. Journal of Urology. 2011 Jun 1;185(6):2102-2107. https://doi.org/10.1016/j.juro.2011.02.020
Barocas, Daniel A. ; Motley, Saundra ; Cookson, Michael S. ; Chang, Sam S. ; Penson, David F. ; Dai, Qi ; Milne, Ginger ; Roberts, L. Jackson ; Morrow, Jason ; Concepcion, Raoul S. ; Smith, Joseph A. ; Fowke, Jay. / Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer. In: Journal of Urology. 2011 ; Vol. 185, No. 6. pp. 2102-2107.
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abstract = "Purpose: Oxidative stress is implicated in prostate cancer by several lines of evidence. We studied the relationship between the level of F2-isoprostanes, a validated biomarker of oxidative stress, and prostate cancer and high grade prostatic intraepithelial neoplasia. Materials and Methods: This case-control analysis within the Nashville Men's Health Study included men recruited at prostate biopsy. Body morphometrics, health history and urine were collected from more than 2,000 men before biopsy. F2-isoprostanes were measured by gas chromatography/mass spectrometry within an age matched sample of Nashville Men's Health Study participants that included 140 patients with high grade prostatic intraepithelial neoplasia, 160 biopsy negative controls and 200 prostate cancer cases. Multivariable linear and logistic regression was used to determine the associations between F2-isoprostane level, and high grade prostatic intraepithelial neoplasia and prostate cancer. Results: Mean patient age was 66.9 years (SD 7.2) and 10.1{\%} were nonwhite. Adjusted geometric mean F2-isoprostane levels were higher in patients with prostate cancer (1.82, 95{\%} CI 1.662.00) or high grade prostatic intraepithelial neoplasia (1.82, 95{\%} CI 1.681.96) than in controls (1.63, 95{\%} CI 1.491.78, p <0.001), but were similar across Gleason scores (p = 0.511). The adjusted odds of high grade prostatic intraepithelial neoplasia and prostate cancer increased with increasing F2-isoprostane quartile (p-trend = 0.015 and 0.047, respectively) and the highest F2-isoprostane quartile was associated with significantly increased odds of prostate cancer (OR 2.44, 95{\%} CI 1.175.09, p = 0.017). Conclusions: Pre-diagnosis urine F2-isoprostane level is increased in men with high grade prostatic intraepithelial neoplasia or prostate cancer, suggesting urinary F2-isoprostane provides a biomarker for the role for oxidative stress in prostate carcinogenesis. F2-isoprostanes may also serve to estimate the efficacy of interventions targeting oxidative stress mechanisms in prostate cancer prevention or treatment.",
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AU - Barocas, Daniel A.

AU - Motley, Saundra

AU - Cookson, Michael S.

AU - Chang, Sam S.

AU - Penson, David F.

AU - Dai, Qi

AU - Milne, Ginger

AU - Roberts, L. Jackson

AU - Morrow, Jason

AU - Concepcion, Raoul S.

AU - Smith, Joseph A.

AU - Fowke, Jay

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N2 - Purpose: Oxidative stress is implicated in prostate cancer by several lines of evidence. We studied the relationship between the level of F2-isoprostanes, a validated biomarker of oxidative stress, and prostate cancer and high grade prostatic intraepithelial neoplasia. Materials and Methods: This case-control analysis within the Nashville Men's Health Study included men recruited at prostate biopsy. Body morphometrics, health history and urine were collected from more than 2,000 men before biopsy. F2-isoprostanes were measured by gas chromatography/mass spectrometry within an age matched sample of Nashville Men's Health Study participants that included 140 patients with high grade prostatic intraepithelial neoplasia, 160 biopsy negative controls and 200 prostate cancer cases. Multivariable linear and logistic regression was used to determine the associations between F2-isoprostane level, and high grade prostatic intraepithelial neoplasia and prostate cancer. Results: Mean patient age was 66.9 years (SD 7.2) and 10.1% were nonwhite. Adjusted geometric mean F2-isoprostane levels were higher in patients with prostate cancer (1.82, 95% CI 1.662.00) or high grade prostatic intraepithelial neoplasia (1.82, 95% CI 1.681.96) than in controls (1.63, 95% CI 1.491.78, p <0.001), but were similar across Gleason scores (p = 0.511). The adjusted odds of high grade prostatic intraepithelial neoplasia and prostate cancer increased with increasing F2-isoprostane quartile (p-trend = 0.015 and 0.047, respectively) and the highest F2-isoprostane quartile was associated with significantly increased odds of prostate cancer (OR 2.44, 95% CI 1.175.09, p = 0.017). Conclusions: Pre-diagnosis urine F2-isoprostane level is increased in men with high grade prostatic intraepithelial neoplasia or prostate cancer, suggesting urinary F2-isoprostane provides a biomarker for the role for oxidative stress in prostate carcinogenesis. F2-isoprostanes may also serve to estimate the efficacy of interventions targeting oxidative stress mechanisms in prostate cancer prevention or treatment.

AB - Purpose: Oxidative stress is implicated in prostate cancer by several lines of evidence. We studied the relationship between the level of F2-isoprostanes, a validated biomarker of oxidative stress, and prostate cancer and high grade prostatic intraepithelial neoplasia. Materials and Methods: This case-control analysis within the Nashville Men's Health Study included men recruited at prostate biopsy. Body morphometrics, health history and urine were collected from more than 2,000 men before biopsy. F2-isoprostanes were measured by gas chromatography/mass spectrometry within an age matched sample of Nashville Men's Health Study participants that included 140 patients with high grade prostatic intraepithelial neoplasia, 160 biopsy negative controls and 200 prostate cancer cases. Multivariable linear and logistic regression was used to determine the associations between F2-isoprostane level, and high grade prostatic intraepithelial neoplasia and prostate cancer. Results: Mean patient age was 66.9 years (SD 7.2) and 10.1% were nonwhite. Adjusted geometric mean F2-isoprostane levels were higher in patients with prostate cancer (1.82, 95% CI 1.662.00) or high grade prostatic intraepithelial neoplasia (1.82, 95% CI 1.681.96) than in controls (1.63, 95% CI 1.491.78, p <0.001), but were similar across Gleason scores (p = 0.511). The adjusted odds of high grade prostatic intraepithelial neoplasia and prostate cancer increased with increasing F2-isoprostane quartile (p-trend = 0.015 and 0.047, respectively) and the highest F2-isoprostane quartile was associated with significantly increased odds of prostate cancer (OR 2.44, 95% CI 1.175.09, p = 0.017). Conclusions: Pre-diagnosis urine F2-isoprostane level is increased in men with high grade prostatic intraepithelial neoplasia or prostate cancer, suggesting urinary F2-isoprostane provides a biomarker for the role for oxidative stress in prostate carcinogenesis. F2-isoprostanes may also serve to estimate the efficacy of interventions targeting oxidative stress mechanisms in prostate cancer prevention or treatment.

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