P450 Gene Nomenclature Based on Evolution

Daniel W. Nebert, David Nelson

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

This chapter discusses the P450 gene nomenclature based on evolution. P450 enzymes are important in the metabolism of numerous physiological substrates such as steroids, fatty acids, prostaglandins, cytokines, bile acids, and biogenic amines. It has been postulated that these enzymes might play an important role in controlling the steady-state level of endogenous effectors of growth and differentiation. Many of these enzymes also metabolize a wide range of foreign chemicals including environmental pollutants, drugs, and natural plant products. The metabolism of foreign chemicals can frequently produce toxic metabolites, some of which are believed to initiate carcinogenesis and tumor promotion. Each P450 gene almost always produces a single protein. Currently, there appear to be two examples in which “functional” alternative splicing might occur—that is, differential processing of the P450 transcript such that entire exons or portions of exons are exchanged to produce an enzyme with a new catalytic activity.

Original languageEnglish (US)
Pages (from-to)3-11
Number of pages9
JournalMethods in Enzymology
Volume206
Issue numberC
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

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Terminology
Genes
Metabolism
Exons
Enzymes
Environmental Pollutants
Biogenic Amines
Poisons
Alternative Splicing
Metabolites
Bile Acids and Salts
Cytochrome P-450 Enzyme System
Prostaglandins
Tumors
Catalyst activity
Carcinogenesis
Fatty Acids
Steroids
Cytokines
Substrates

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

P450 Gene Nomenclature Based on Evolution. / Nebert, Daniel W.; Nelson, David.

In: Methods in Enzymology, Vol. 206, No. C, 01.01.1991, p. 3-11.

Research output: Contribution to journalArticle

Nebert, Daniel W. ; Nelson, David. / P450 Gene Nomenclature Based on Evolution. In: Methods in Enzymology. 1991 ; Vol. 206, No. C. pp. 3-11.
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