P450 superfamily

Update on new sequences, gene mapping, accession numbers and nomenclature

David Nelson, Luc Koymans, Tetsuya Kamataki, John J. Stegeman, René Feyereisen, David J. Waxman, Michael R. Waterman, Osamu Gotoh, Minor J. Coon, Ron W. Estabrook, Irwin C. Gunsalus, Daniel W. Nebert

Research output: Contribution to journalReview article

2479 Citations (Scopus)

Abstract

We provide here a list of 481 P450 genes and 22 pseudogenes, plus all accession numbers that have been reported as of October 18, 1995. These genes have been described in 85 eukaryote (including vertebrates, invertebrates, fungi, and plants) and 20 prokaryotic species. Of 74 gene families so far described, 14 families exist in all mammals examined to date. These 14 families comprise 26 mammalian subfamilies, of which 20 and 15 have been mapped in the human genome and the mouse genome, respectively. Each subfamily usually represents a cluster of tightly linked genes widely scattered throughout the genome, but there are exceptions. Interestingly, the CYP51 family has been found in mammals, filamentous fungi and yeast, and plants - attesting to the fact that this P450 gene family is very ancient. One functional CYP51 gene and two processed pseudogenes, which are the first examples of intronless pseudogenes within the P450 superfamily, have been mapped to three different human chromosomes. This revision supersedes the four previous updates in which a nomenclature system, based on divergent evolution of the superfamily, has been described. For the gene, we recommend that the italicized root symbol 'CYP' for human ('Cyp' for mouse and Drosophila), representing 'cytochrome P450', be followed by an Arabic number denoting the family, a letter designating the subfamily (when two or more exist), and an Arabic numeral representing the individual gene within the subfamily. A hyphen is no longer recommended in mouse gene nomenclature. 'P' ('ps' in mouse and Drosophila) after the gene number denotes a pseudogene; 'X' after the gene number means its use has been discontinued. If a gene is the sole member of a family, the subfamily letter and gene number would be helpful but need not be included. The human nomenclature system should be used for all species other than mouse and Drosophila. The cDNAs, mRNAs and enzymes in all species (including mouse) should include all capital letters, and without italics or hyphens. This nomenclature system is similar to that proposed in our previous updates.

Original languageEnglish (US)
Pages (from-to)1-42
Number of pages42
JournalPharmacogenetics
Volume6
Issue number1
DOIs
StatePublished - Apr 2 1996

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Chromosome Mapping
Terminology
Pseudogenes
Genes
Drosophila
Mammals
Fungi
Genome
Human Chromosomes
Human Genome
Invertebrates
Eukaryota
Cytochrome P-450 Enzyme System
Vertebrates
Complementary DNA
Yeasts

All Science Journal Classification (ASJC) codes

  • Genetics
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Nelson, D., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., ... Nebert, D. W. (1996). P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6(1), 1-42. https://doi.org/10.1097/00008571-199602000-00002

P450 superfamily : Update on new sequences, gene mapping, accession numbers and nomenclature. / Nelson, David; Koymans, Luc; Kamataki, Tetsuya; Stegeman, John J.; Feyereisen, René; Waxman, David J.; Waterman, Michael R.; Gotoh, Osamu; Coon, Minor J.; Estabrook, Ron W.; Gunsalus, Irwin C.; Nebert, Daniel W.

In: Pharmacogenetics, Vol. 6, No. 1, 02.04.1996, p. 1-42.

Research output: Contribution to journalReview article

Nelson, D, Koymans, L, Kamataki, T, Stegeman, JJ, Feyereisen, R, Waxman, DJ, Waterman, MR, Gotoh, O, Coon, MJ, Estabrook, RW, Gunsalus, IC & Nebert, DW 1996, 'P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature', Pharmacogenetics, vol. 6, no. 1, pp. 1-42. https://doi.org/10.1097/00008571-199602000-00002
Nelson, David ; Koymans, Luc ; Kamataki, Tetsuya ; Stegeman, John J. ; Feyereisen, René ; Waxman, David J. ; Waterman, Michael R. ; Gotoh, Osamu ; Coon, Minor J. ; Estabrook, Ron W. ; Gunsalus, Irwin C. ; Nebert, Daniel W. / P450 superfamily : Update on new sequences, gene mapping, accession numbers and nomenclature. In: Pharmacogenetics. 1996 ; Vol. 6, No. 1. pp. 1-42.
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