Dolor y malestar. Un ejemplo experimental de interacción neuro-inmune

Translated title of the contribution: Pain and sickness. An experimental example of neuro-immune interaction

Victor Tortorici, David Vásquez-Dundell, Sindy Devis, Carlos Fernandez Pena Acuna, Beatriz Brito

Research output: Contribution to journalArticle

Abstract

The definition of sickness/illness behavior involves a constellation of signs and symptoms such as fever, decrease of physical activity, anorexia, decrease of libido, insomnia and changes of the pain threshold, among others. These manifestations are necessary to face infectious processes and are apparently initiated and controlled by the immune and the nervous system, so that they represent an ideal example of interaction between both components. In the present study the behavioral changes in the pain threshold induced by the i.p. administration of lipopolysaccharide, an endotoxin derived from gram-negative bacterial cell walls, were analyzed. Additionally, changes in the discharge pattern of two neuronal populations of the medullary reticular formation, the off- and on-cells, which apparently act as the executory arm of the endogenous pain modulatory system were determined after endotoxin administration. The results indicate that depending on the LPS dose (100 or 200 μg/kg) different modulatory mechanisms might be activated, which in turn seem to be the consequence of the activation of the two different classes of medullary neurons. Antinociception was produced after administration of 100 μg/kg of LPS. That was associated to an increase of the off-cell firing and a reduction of the on-cell activity. Hyperalgesia was produced after administration of 200 μg/kg of LPS. That effect was accompanied by an inhibition of the off-cell activity and an increase of the on-cell firing. These findings suggest that changes of the pain threshold that occur during sickness/illness involve the differential participation of the two control options of the endogenous pain modulatory system and of specialized mechanisms of communication between the immune and the nervous system.

Original languageSpanish
Pages (from-to)139-148
Number of pages10
JournalActa Cientifica Venezolana
Volume56
Issue number4
StatePublished - Dec 1 2005

Fingerprint

pain
Pain Threshold
Pain
Neurology
Illness Behavior
nervous system
Endotoxins
endotoxins
Nervous System
cells
Immune System
physical activity
libido
Libido
Reticular Formation
Neurons
Hyperalgesia
Lipopolysaccharides
Sleep Initiation and Maintenance Disorders
Anorexia

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Tortorici, V., Vásquez-Dundell, D., Devis, S., Fernandez Pena Acuna, C., & Brito, B. (2005). Dolor y malestar. Un ejemplo experimental de interacción neuro-inmune. Acta Cientifica Venezolana, 56(4), 139-148.

Dolor y malestar. Un ejemplo experimental de interacción neuro-inmune. / Tortorici, Victor; Vásquez-Dundell, David; Devis, Sindy; Fernandez Pena Acuna, Carlos; Brito, Beatriz.

In: Acta Cientifica Venezolana, Vol. 56, No. 4, 01.12.2005, p. 139-148.

Research output: Contribution to journalArticle

Tortorici, V, Vásquez-Dundell, D, Devis, S, Fernandez Pena Acuna, C & Brito, B 2005, 'Dolor y malestar. Un ejemplo experimental de interacción neuro-inmune', Acta Cientifica Venezolana, vol. 56, no. 4, pp. 139-148.
Tortorici V, Vásquez-Dundell D, Devis S, Fernandez Pena Acuna C, Brito B. Dolor y malestar. Un ejemplo experimental de interacción neuro-inmune. Acta Cientifica Venezolana. 2005 Dec 1;56(4):139-148.
Tortorici, Victor ; Vásquez-Dundell, David ; Devis, Sindy ; Fernandez Pena Acuna, Carlos ; Brito, Beatriz. / Dolor y malestar. Un ejemplo experimental de interacción neuro-inmune. In: Acta Cientifica Venezolana. 2005 ; Vol. 56, No. 4. pp. 139-148.
@article{af15093b82be4b0aa671dc57ddd54cb1,
title = "Dolor y malestar. Un ejemplo experimental de interacci{\'o}n neuro-inmune",
abstract = "The definition of sickness/illness behavior involves a constellation of signs and symptoms such as fever, decrease of physical activity, anorexia, decrease of libido, insomnia and changes of the pain threshold, among others. These manifestations are necessary to face infectious processes and are apparently initiated and controlled by the immune and the nervous system, so that they represent an ideal example of interaction between both components. In the present study the behavioral changes in the pain threshold induced by the i.p. administration of lipopolysaccharide, an endotoxin derived from gram-negative bacterial cell walls, were analyzed. Additionally, changes in the discharge pattern of two neuronal populations of the medullary reticular formation, the off- and on-cells, which apparently act as the executory arm of the endogenous pain modulatory system were determined after endotoxin administration. The results indicate that depending on the LPS dose (100 or 200 μg/kg) different modulatory mechanisms might be activated, which in turn seem to be the consequence of the activation of the two different classes of medullary neurons. Antinociception was produced after administration of 100 μg/kg of LPS. That was associated to an increase of the off-cell firing and a reduction of the on-cell activity. Hyperalgesia was produced after administration of 200 μg/kg of LPS. That effect was accompanied by an inhibition of the off-cell activity and an increase of the on-cell firing. These findings suggest that changes of the pain threshold that occur during sickness/illness involve the differential participation of the two control options of the endogenous pain modulatory system and of specialized mechanisms of communication between the immune and the nervous system.",
author = "Victor Tortorici and David V{\'a}squez-Dundell and Sindy Devis and {Fernandez Pena Acuna}, Carlos and Beatriz Brito",
year = "2005",
month = "12",
day = "1",
language = "Spanish",
volume = "56",
pages = "139--148",
journal = "Acta Cientifica Venezolana",
issn = "0001-5504",
publisher = "Edificio FundaVAC - AsoVAC",
number = "4",

}

TY - JOUR

T1 - Dolor y malestar. Un ejemplo experimental de interacción neuro-inmune

AU - Tortorici, Victor

AU - Vásquez-Dundell, David

AU - Devis, Sindy

AU - Fernandez Pena Acuna, Carlos

AU - Brito, Beatriz

PY - 2005/12/1

Y1 - 2005/12/1

N2 - The definition of sickness/illness behavior involves a constellation of signs and symptoms such as fever, decrease of physical activity, anorexia, decrease of libido, insomnia and changes of the pain threshold, among others. These manifestations are necessary to face infectious processes and are apparently initiated and controlled by the immune and the nervous system, so that they represent an ideal example of interaction between both components. In the present study the behavioral changes in the pain threshold induced by the i.p. administration of lipopolysaccharide, an endotoxin derived from gram-negative bacterial cell walls, were analyzed. Additionally, changes in the discharge pattern of two neuronal populations of the medullary reticular formation, the off- and on-cells, which apparently act as the executory arm of the endogenous pain modulatory system were determined after endotoxin administration. The results indicate that depending on the LPS dose (100 or 200 μg/kg) different modulatory mechanisms might be activated, which in turn seem to be the consequence of the activation of the two different classes of medullary neurons. Antinociception was produced after administration of 100 μg/kg of LPS. That was associated to an increase of the off-cell firing and a reduction of the on-cell activity. Hyperalgesia was produced after administration of 200 μg/kg of LPS. That effect was accompanied by an inhibition of the off-cell activity and an increase of the on-cell firing. These findings suggest that changes of the pain threshold that occur during sickness/illness involve the differential participation of the two control options of the endogenous pain modulatory system and of specialized mechanisms of communication between the immune and the nervous system.

AB - The definition of sickness/illness behavior involves a constellation of signs and symptoms such as fever, decrease of physical activity, anorexia, decrease of libido, insomnia and changes of the pain threshold, among others. These manifestations are necessary to face infectious processes and are apparently initiated and controlled by the immune and the nervous system, so that they represent an ideal example of interaction between both components. In the present study the behavioral changes in the pain threshold induced by the i.p. administration of lipopolysaccharide, an endotoxin derived from gram-negative bacterial cell walls, were analyzed. Additionally, changes in the discharge pattern of two neuronal populations of the medullary reticular formation, the off- and on-cells, which apparently act as the executory arm of the endogenous pain modulatory system were determined after endotoxin administration. The results indicate that depending on the LPS dose (100 or 200 μg/kg) different modulatory mechanisms might be activated, which in turn seem to be the consequence of the activation of the two different classes of medullary neurons. Antinociception was produced after administration of 100 μg/kg of LPS. That was associated to an increase of the off-cell firing and a reduction of the on-cell activity. Hyperalgesia was produced after administration of 200 μg/kg of LPS. That effect was accompanied by an inhibition of the off-cell activity and an increase of the on-cell firing. These findings suggest that changes of the pain threshold that occur during sickness/illness involve the differential participation of the two control options of the endogenous pain modulatory system and of specialized mechanisms of communication between the immune and the nervous system.

UR - http://www.scopus.com/inward/record.url?scp=72149114861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72149114861&partnerID=8YFLogxK

M3 - Article

VL - 56

SP - 139

EP - 148

JO - Acta Cientifica Venezolana

JF - Acta Cientifica Venezolana

SN - 0001-5504

IS - 4

ER -