Pain in Parkinson's disease

A cross-sectional study of its prevalence, types, and relationship to depression and quality of life

Peter Valkovic, Michal Minar, Helena Singliarova, Jan Harsany, Marta Hanakova, Jana Martinkova, Jan Benetin, Mark Ledoux

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Pain is an important and distressing symptom in Parkinson's disease (PD). Our aim was to determine the prevalence of pain, its various types and characteristics, as well as its impact on depression and quality of life (QoL) in patients with PD. How pain differs in early- and advanced-stage PD and male and female PD patients was of special interest. One hundred PD patients on dopaminergic medications had a neurological examination and participated in a structured interview on pain characteristics and completed standardized questionnaires. A total of 76% of the patients had pain. The following types of pain were present: musculoskeletal pain accounted for 41% of the total pain, dystonic pain for 17%, central neuropathic pain for 22%, radicular pain for 27%, and other pains (non-radicular low back pain, arthritic, and visceral pain) made up 24%. One type of pain affected 29% of all the subjects, two types 35%, three types 10%, and four types of pain were reported by 2%. All types of pain were more prevalent in advanced-stage PD subjects than in early-stage PD subjects, except for arthritic pain (subclassified under "other pain"). The frequency and intensity of actual, average, and worst experienced pain were significantly more severe in advanced-stage subjects. PD subjects with general pain and in advanced stages were more depressed and had poorer QoL. Depression correlated with worst pain in the last 24 hours and with pain periodicity (the worst depression score in patients with constant pain). QoL correlated with average pain in the last 7 days. Pain is a frequent problem in PD patients, and it worsens during the course of the disease.

Original languageEnglish (US)
Article numbere0136541
JournalPloS one
Volume10
Issue number8
DOIs
StatePublished - Aug 26 2015

Fingerprint

Parkinson disease
quality of life
cross-sectional studies
Parkinson Disease
pain
Cross-Sectional Studies
Quality of Life
Depression
Pain
arthritis
Arthritis
Visceral Pain
Musculoskeletal Pain

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Pain in Parkinson's disease : A cross-sectional study of its prevalence, types, and relationship to depression and quality of life. / Valkovic, Peter; Minar, Michal; Singliarova, Helena; Harsany, Jan; Hanakova, Marta; Martinkova, Jana; Benetin, Jan; Ledoux, Mark.

In: PloS one, Vol. 10, No. 8, e0136541, 26.08.2015.

Research output: Contribution to journalArticle

Valkovic, Peter ; Minar, Michal ; Singliarova, Helena ; Harsany, Jan ; Hanakova, Marta ; Martinkova, Jana ; Benetin, Jan ; Ledoux, Mark. / Pain in Parkinson's disease : A cross-sectional study of its prevalence, types, and relationship to depression and quality of life. In: PloS one. 2015 ; Vol. 10, No. 8.
@article{cf58e53a09f34908a075d48c17220a54,
title = "Pain in Parkinson's disease: A cross-sectional study of its prevalence, types, and relationship to depression and quality of life",
abstract = "Pain is an important and distressing symptom in Parkinson's disease (PD). Our aim was to determine the prevalence of pain, its various types and characteristics, as well as its impact on depression and quality of life (QoL) in patients with PD. How pain differs in early- and advanced-stage PD and male and female PD patients was of special interest. One hundred PD patients on dopaminergic medications had a neurological examination and participated in a structured interview on pain characteristics and completed standardized questionnaires. A total of 76{\%} of the patients had pain. The following types of pain were present: musculoskeletal pain accounted for 41{\%} of the total pain, dystonic pain for 17{\%}, central neuropathic pain for 22{\%}, radicular pain for 27{\%}, and other pains (non-radicular low back pain, arthritic, and visceral pain) made up 24{\%}. One type of pain affected 29{\%} of all the subjects, two types 35{\%}, three types 10{\%}, and four types of pain were reported by 2{\%}. All types of pain were more prevalent in advanced-stage PD subjects than in early-stage PD subjects, except for arthritic pain (subclassified under {"}other pain{"}). The frequency and intensity of actual, average, and worst experienced pain were significantly more severe in advanced-stage subjects. PD subjects with general pain and in advanced stages were more depressed and had poorer QoL. Depression correlated with worst pain in the last 24 hours and with pain periodicity (the worst depression score in patients with constant pain). QoL correlated with average pain in the last 7 days. Pain is a frequent problem in PD patients, and it worsens during the course of the disease.",
author = "Peter Valkovic and Michal Minar and Helena Singliarova and Jan Harsany and Marta Hanakova and Jana Martinkova and Jan Benetin and Mark Ledoux",
year = "2015",
month = "8",
day = "26",
doi = "10.1371/journal.pone.0136541",
language = "English (US)",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

TY - JOUR

T1 - Pain in Parkinson's disease

T2 - A cross-sectional study of its prevalence, types, and relationship to depression and quality of life

AU - Valkovic, Peter

AU - Minar, Michal

AU - Singliarova, Helena

AU - Harsany, Jan

AU - Hanakova, Marta

AU - Martinkova, Jana

AU - Benetin, Jan

AU - Ledoux, Mark

PY - 2015/8/26

Y1 - 2015/8/26

N2 - Pain is an important and distressing symptom in Parkinson's disease (PD). Our aim was to determine the prevalence of pain, its various types and characteristics, as well as its impact on depression and quality of life (QoL) in patients with PD. How pain differs in early- and advanced-stage PD and male and female PD patients was of special interest. One hundred PD patients on dopaminergic medications had a neurological examination and participated in a structured interview on pain characteristics and completed standardized questionnaires. A total of 76% of the patients had pain. The following types of pain were present: musculoskeletal pain accounted for 41% of the total pain, dystonic pain for 17%, central neuropathic pain for 22%, radicular pain for 27%, and other pains (non-radicular low back pain, arthritic, and visceral pain) made up 24%. One type of pain affected 29% of all the subjects, two types 35%, three types 10%, and four types of pain were reported by 2%. All types of pain were more prevalent in advanced-stage PD subjects than in early-stage PD subjects, except for arthritic pain (subclassified under "other pain"). The frequency and intensity of actual, average, and worst experienced pain were significantly more severe in advanced-stage subjects. PD subjects with general pain and in advanced stages were more depressed and had poorer QoL. Depression correlated with worst pain in the last 24 hours and with pain periodicity (the worst depression score in patients with constant pain). QoL correlated with average pain in the last 7 days. Pain is a frequent problem in PD patients, and it worsens during the course of the disease.

AB - Pain is an important and distressing symptom in Parkinson's disease (PD). Our aim was to determine the prevalence of pain, its various types and characteristics, as well as its impact on depression and quality of life (QoL) in patients with PD. How pain differs in early- and advanced-stage PD and male and female PD patients was of special interest. One hundred PD patients on dopaminergic medications had a neurological examination and participated in a structured interview on pain characteristics and completed standardized questionnaires. A total of 76% of the patients had pain. The following types of pain were present: musculoskeletal pain accounted for 41% of the total pain, dystonic pain for 17%, central neuropathic pain for 22%, radicular pain for 27%, and other pains (non-radicular low back pain, arthritic, and visceral pain) made up 24%. One type of pain affected 29% of all the subjects, two types 35%, three types 10%, and four types of pain were reported by 2%. All types of pain were more prevalent in advanced-stage PD subjects than in early-stage PD subjects, except for arthritic pain (subclassified under "other pain"). The frequency and intensity of actual, average, and worst experienced pain were significantly more severe in advanced-stage subjects. PD subjects with general pain and in advanced stages were more depressed and had poorer QoL. Depression correlated with worst pain in the last 24 hours and with pain periodicity (the worst depression score in patients with constant pain). QoL correlated with average pain in the last 7 days. Pain is a frequent problem in PD patients, and it worsens during the course of the disease.

UR - http://www.scopus.com/inward/record.url?scp=84943252468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943252468&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0136541

DO - 10.1371/journal.pone.0136541

M3 - Article

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 8

M1 - e0136541

ER -