Pancreatic nerve response induced by hypothalamic stimulation in rats

Hitoshi Kita, A. Niijima, Y. Oomura, S. Ishizuka, S. Aou, K. Yamabe, H. Yoshimatsu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Hypothalamic control of pancreatic vagal and splanchnic nerve activity was studied using anesthetized rats. Vagal nerve activity was inhibited by repetitive stimulation (2-100 Hz) of the ventromedial hypothalamic nucleus (VMH) and the ventromedial part of the lateral hypothalamic area (LHA), and facilitated by stimulation of the ventrolateral part of the LHA. Splanchnic nerve activity was facilitated by stimulation of the dorsal part of the LHA. Stimulation of the VMH and the ventromedial and central parts of the LHA produced complex responses in the splanchnic nerve. Inhibition was dominant during low frequency stimulation (less than 20 Hz) and facilitation dominated during high frequency stimulation (more than 50 Hz). The results provide evidence of hypothalamic control of autonomie nervous regulation of pancreatic hormone secretion, and demonstrate that ablation or stimulation of relatively limited regions in the hypothalamus affect these nerves.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalBrain Research Bulletin
Volume5
Issue numberSUPPL. 4
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

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Lateral Hypothalamic Area
Splanchnic Nerves
Ventromedial Hypothalamic Nucleus
Pancreatic Hormones
Hypothalamus

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Kita, H., Niijima, A., Oomura, Y., Ishizuka, S., Aou, S., Yamabe, K., & Yoshimatsu, H. (1980). Pancreatic nerve response induced by hypothalamic stimulation in rats. Brain Research Bulletin, 5(SUPPL. 4), 163-168. https://doi.org/10.1016/0361-9230(80)90245-2

Pancreatic nerve response induced by hypothalamic stimulation in rats. / Kita, Hitoshi; Niijima, A.; Oomura, Y.; Ishizuka, S.; Aou, S.; Yamabe, K.; Yoshimatsu, H.

In: Brain Research Bulletin, Vol. 5, No. SUPPL. 4, 01.01.1980, p. 163-168.

Research output: Contribution to journalArticle

Kita, H, Niijima, A, Oomura, Y, Ishizuka, S, Aou, S, Yamabe, K & Yoshimatsu, H 1980, 'Pancreatic nerve response induced by hypothalamic stimulation in rats', Brain Research Bulletin, vol. 5, no. SUPPL. 4, pp. 163-168. https://doi.org/10.1016/0361-9230(80)90245-2
Kita, Hitoshi ; Niijima, A. ; Oomura, Y. ; Ishizuka, S. ; Aou, S. ; Yamabe, K. ; Yoshimatsu, H. / Pancreatic nerve response induced by hypothalamic stimulation in rats. In: Brain Research Bulletin. 1980 ; Vol. 5, No. SUPPL. 4. pp. 163-168.
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