Parabrachial neuron discharge in the cat is altered during the carbachol-induced REM sleep-like state (DCarb)

Kirk A. Gilbert, Ralph Lydic

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Pontine parabrachial neurons have been suggested to play a regulatory role in both respiratory and sleep cycle control. Encouraged by the finding that microinjections of the cholinergic agonist carbachol into the medial pontine reticular formation (mPRF) of the cat produced respiratory changes paralleling those observed during rapid eye movement (REM) sleep (Neurosci. Lett., 102 (1989) 211-216), this study tested the hypothesis that cholinergic mechanisms in the mPRF can also cause state-dependent changes in the discharge of parabrachial neurons. This paper describes extracellular recordings of parabrachial neurons during REM sleep and during the carbachol-induced REM sleep-like state (DCarb). Cells which were activated (REM-on) or inactivated (REM-off) during REM maintained these same state-dependent firing patterns during the DCarb state. These results support the hypothesis that cholinergic mechanisms in the mPRF can cause state-dependent changes in the discharge of parabrachial neurons.

Original languageEnglish (US)
Pages (from-to)241-244
Number of pages4
JournalNeuroscience Letters
Volume120
Issue number2
DOIs
StatePublished - Dec 11 1990
Externally publishedYes

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REM Sleep
Carbachol
Sleep
Cats
Neurons
Cholinergic Agents
Cholinergic Agonists
Microinjections
Pontine Tegmentum

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Parabrachial neuron discharge in the cat is altered during the carbachol-induced REM sleep-like state (DCarb). / Gilbert, Kirk A.; Lydic, Ralph.

In: Neuroscience Letters, Vol. 120, No. 2, 11.12.1990, p. 241-244.

Research output: Contribution to journalArticle

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