Parameters of quantitative trait loci

Jian Yan, Weikuan Gu

Research output: Contribution to journalReview article

Abstract

Most traits of medical relevance follow quantitative inheritance patterns. The genetic dissection of quantitative traits poses special challenges for geneticists mainly because of low penetrance and gene-gene and gene-environment interactions. Emerging genome resources and technologies are enabling systematic investigation of the genetic architecture of quantitative traits in more efficient ways. This article summarizes the current state of medical quantitative trait locus (QTL) mapping - describing the methods, limitations, and achievements in the detection and characterization of QTLs.

Original languageEnglish (US)
Pages (from-to)335-346
Number of pages12
JournalCritical Reviews in Eukaryotic Gene Expression
Volume17
Issue number4
DOIs
StatePublished - Jan 1 2007

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Quantitative Trait Loci
Inheritance Patterns
Gene-Environment Interaction
Penetrance
Genes
Dissection
Genome
Technology

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

Cite this

Parameters of quantitative trait loci. / Yan, Jian; Gu, Weikuan.

In: Critical Reviews in Eukaryotic Gene Expression, Vol. 17, No. 4, 01.01.2007, p. 335-346.

Research output: Contribution to journalReview article

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