Paraoxonase Arg 192 allele is an independent risk factor for three-vessel stenosis of coronary artery disease

Asad Vaisi-Raygani, Hori Ghaneialvar, Zohreh Rahimi, Haidar Tavilani, Tayebeh Pourmotabbed, Ebrahim Shakiba, Aliakbar Vaisi-Raygani, Amir Kiani, Mahdi Aminian, Reza Alibakhshi, Cynthia Bartels

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Abstract

The role of the paraoxonase (PON1) codon 192 polymorphism [glutamine (Q)/arginine (R)] in coronary artery disease (CAD) is controversial. The aim of the present study was to evaluate whether the PON1 gene polymorphism is an independent risk factor for severity of coronary artery disease in patients from west of Iran. The PON1-Arg-192 genotypes were detected by PCR-RFLP in 414 individuals undergoing their first coronary angiography. Patients were placed into one of two groups: CAD and control without CAD or diabetes. The frequency of PON1-Arg-192 allele was significantly higher in the CAD (23.4 vs. 16%, P = 0.032) than in the control group and there was a higher risk of developing CAD (OR = 1.6, P = 0.02). In addition, this difference remained significant after adjustment for without history of diabetes (OR = 1.47, P = 0.048), presence of normolipidemia and absence of history of blood pressure (OR = 1.4, P = 0.05). This result indicated PON1-Arg-192 allele is a risk factor of CAD also when correcting for conventional risk factors. We found a significant association between the PON1-Arg-192 genotype (QR? RR) and the extent of CAD in CAD patients and CAD subjects without diabetes, represented by the increased frequency of three-vessel disease with OR = 1.49, P = 0.046; χ 2 = 3.82, P = 0.048 and OR = 1.46, P = 0.05; χ 2 = 3.48, P = 0.051, respectively. The CAD patients carrying PON1-Arg-192 genotype (QR + RR) had lower plasma HDL-C level (P = 0.019) and higher plasma LDL-C(P = 0.01) and TG(P = 0.05). Our results indicated that PON1-Arg-192 allele can be important independent risk factor of CAD in a west population of Iran, with carriers of PON1-Arg-192 having an increased frequency of threevessel disease and also having a distinct plasma lipids profile. Larger collaborative studies are needed to confirm these results.

Original languageEnglish (US)
Pages (from-to)5421-5428
Number of pages8
JournalMolecular Biology Reports
Volume38
Issue number8
DOIs
StatePublished - Nov 1 2011

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Aryldialkylphosphatase
Coronary Artery Disease
Pathologic Constriction
Alleles
Genotype
Iran
Coronary Angiography
Glutamine
Codon
Restriction Fragment Length Polymorphisms
Arginine

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

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Paraoxonase Arg 192 allele is an independent risk factor for three-vessel stenosis of coronary artery disease. / Vaisi-Raygani, Asad; Ghaneialvar, Hori; Rahimi, Zohreh; Tavilani, Haidar; Pourmotabbed, Tayebeh; Shakiba, Ebrahim; Vaisi-Raygani, Aliakbar; Kiani, Amir; Aminian, Mahdi; Alibakhshi, Reza; Bartels, Cynthia.

In: Molecular Biology Reports, Vol. 38, No. 8, 01.11.2011, p. 5421-5428.

Research output: Contribution to journalArticle

Vaisi-Raygani, A, Ghaneialvar, H, Rahimi, Z, Tavilani, H, Pourmotabbed, T, Shakiba, E, Vaisi-Raygani, A, Kiani, A, Aminian, M, Alibakhshi, R & Bartels, C 2011, 'Paraoxonase Arg 192 allele is an independent risk factor for three-vessel stenosis of coronary artery disease', Molecular Biology Reports, vol. 38, no. 8, pp. 5421-5428. https://doi.org/10.1007/s11033-011-0696-3
Vaisi-Raygani, Asad ; Ghaneialvar, Hori ; Rahimi, Zohreh ; Tavilani, Haidar ; Pourmotabbed, Tayebeh ; Shakiba, Ebrahim ; Vaisi-Raygani, Aliakbar ; Kiani, Amir ; Aminian, Mahdi ; Alibakhshi, Reza ; Bartels, Cynthia. / Paraoxonase Arg 192 allele is an independent risk factor for three-vessel stenosis of coronary artery disease. In: Molecular Biology Reports. 2011 ; Vol. 38, No. 8. pp. 5421-5428.
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abstract = "The role of the paraoxonase (PON1) codon 192 polymorphism [glutamine (Q)/arginine (R)] in coronary artery disease (CAD) is controversial. The aim of the present study was to evaluate whether the PON1 gene polymorphism is an independent risk factor for severity of coronary artery disease in patients from west of Iran. The PON1-Arg-192 genotypes were detected by PCR-RFLP in 414 individuals undergoing their first coronary angiography. Patients were placed into one of two groups: CAD and control without CAD or diabetes. The frequency of PON1-Arg-192 allele was significantly higher in the CAD (23.4 vs. 16{\%}, P = 0.032) than in the control group and there was a higher risk of developing CAD (OR = 1.6, P = 0.02). In addition, this difference remained significant after adjustment for without history of diabetes (OR = 1.47, P = 0.048), presence of normolipidemia and absence of history of blood pressure (OR = 1.4, P = 0.05). This result indicated PON1-Arg-192 allele is a risk factor of CAD also when correcting for conventional risk factors. We found a significant association between the PON1-Arg-192 genotype (QR? RR) and the extent of CAD in CAD patients and CAD subjects without diabetes, represented by the increased frequency of three-vessel disease with OR = 1.49, P = 0.046; χ 2 = 3.82, P = 0.048 and OR = 1.46, P = 0.05; χ 2 = 3.48, P = 0.051, respectively. The CAD patients carrying PON1-Arg-192 genotype (QR + RR) had lower plasma HDL-C level (P = 0.019) and higher plasma LDL-C(P = 0.01) and TG(P = 0.05). Our results indicated that PON1-Arg-192 allele can be important independent risk factor of CAD in a west population of Iran, with carriers of PON1-Arg-192 having an increased frequency of threevessel disease and also having a distinct plasma lipids profile. Larger collaborative studies are needed to confirm these results.",
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AU - Vaisi-Raygani, Asad

AU - Ghaneialvar, Hori

AU - Rahimi, Zohreh

AU - Tavilani, Haidar

AU - Pourmotabbed, Tayebeh

AU - Shakiba, Ebrahim

AU - Vaisi-Raygani, Aliakbar

AU - Kiani, Amir

AU - Aminian, Mahdi

AU - Alibakhshi, Reza

AU - Bartels, Cynthia

PY - 2011/11/1

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N2 - The role of the paraoxonase (PON1) codon 192 polymorphism [glutamine (Q)/arginine (R)] in coronary artery disease (CAD) is controversial. The aim of the present study was to evaluate whether the PON1 gene polymorphism is an independent risk factor for severity of coronary artery disease in patients from west of Iran. The PON1-Arg-192 genotypes were detected by PCR-RFLP in 414 individuals undergoing their first coronary angiography. Patients were placed into one of two groups: CAD and control without CAD or diabetes. The frequency of PON1-Arg-192 allele was significantly higher in the CAD (23.4 vs. 16%, P = 0.032) than in the control group and there was a higher risk of developing CAD (OR = 1.6, P = 0.02). In addition, this difference remained significant after adjustment for without history of diabetes (OR = 1.47, P = 0.048), presence of normolipidemia and absence of history of blood pressure (OR = 1.4, P = 0.05). This result indicated PON1-Arg-192 allele is a risk factor of CAD also when correcting for conventional risk factors. We found a significant association between the PON1-Arg-192 genotype (QR? RR) and the extent of CAD in CAD patients and CAD subjects without diabetes, represented by the increased frequency of three-vessel disease with OR = 1.49, P = 0.046; χ 2 = 3.82, P = 0.048 and OR = 1.46, P = 0.05; χ 2 = 3.48, P = 0.051, respectively. The CAD patients carrying PON1-Arg-192 genotype (QR + RR) had lower plasma HDL-C level (P = 0.019) and higher plasma LDL-C(P = 0.01) and TG(P = 0.05). Our results indicated that PON1-Arg-192 allele can be important independent risk factor of CAD in a west population of Iran, with carriers of PON1-Arg-192 having an increased frequency of threevessel disease and also having a distinct plasma lipids profile. Larger collaborative studies are needed to confirm these results.

AB - The role of the paraoxonase (PON1) codon 192 polymorphism [glutamine (Q)/arginine (R)] in coronary artery disease (CAD) is controversial. The aim of the present study was to evaluate whether the PON1 gene polymorphism is an independent risk factor for severity of coronary artery disease in patients from west of Iran. The PON1-Arg-192 genotypes were detected by PCR-RFLP in 414 individuals undergoing their first coronary angiography. Patients were placed into one of two groups: CAD and control without CAD or diabetes. The frequency of PON1-Arg-192 allele was significantly higher in the CAD (23.4 vs. 16%, P = 0.032) than in the control group and there was a higher risk of developing CAD (OR = 1.6, P = 0.02). In addition, this difference remained significant after adjustment for without history of diabetes (OR = 1.47, P = 0.048), presence of normolipidemia and absence of history of blood pressure (OR = 1.4, P = 0.05). This result indicated PON1-Arg-192 allele is a risk factor of CAD also when correcting for conventional risk factors. We found a significant association between the PON1-Arg-192 genotype (QR? RR) and the extent of CAD in CAD patients and CAD subjects without diabetes, represented by the increased frequency of three-vessel disease with OR = 1.49, P = 0.046; χ 2 = 3.82, P = 0.048 and OR = 1.46, P = 0.05; χ 2 = 3.48, P = 0.051, respectively. The CAD patients carrying PON1-Arg-192 genotype (QR + RR) had lower plasma HDL-C level (P = 0.019) and higher plasma LDL-C(P = 0.01) and TG(P = 0.05). Our results indicated that PON1-Arg-192 allele can be important independent risk factor of CAD in a west population of Iran, with carriers of PON1-Arg-192 having an increased frequency of threevessel disease and also having a distinct plasma lipids profile. Larger collaborative studies are needed to confirm these results.

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