Parental history of type 2 diabetes abrogates ethnic disparities in key glucoregulatory indices

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Abstract

Context: There are ethnic differences in glucoregulation and prevalence of type 2 diabetes, but studies on the role of genetics in modifying ethnic effects in normoglycemic African-Americans and Caucasians are limited. Therefore, we investigated glucoregulation in normoglycemic African- Americans and Caucasians with or without parental diabetes. Design: Fifty subjects with parental diabetes (from the Pathobiology of Prediabetes in a Biracial Cohort Study) and 50 subjects without parental diabetes were matched in age, sex, ethnicity, and body mass index (BMI). Subjects underwent a 75-g oral glucose tolerance test (OGTT), physical examination, anthropometry, biochemistries, indirect calorimetry and assessment of body composition, insulin sensitivity by euglycemic clamp (Si-clamp), and b-cell function by Disposition index. Results: The mean age was 40.5 ± 11.6 years, BMI 28.7 ± 5.9 kg/m2, fasting plasma glucose 90.2 ± 5.9 mg/dL, and 2-hour postglucose 120.0 ± 26.8 mg/dL. Offspring with parental diabetes showed higher glycemic excursion during OGTT-Area under the curve-glucose (16,005.6 ± 2324.7 vs 14,973.8 ± 1819.9, P< 0.005), lower Si-clamp (0.132 ± 0.068 vs 0.162 ± 0.081 mmol/kg fat-free mass/min/pmol/L, P< 0.05), and lower Disposition index (8.74 ± 5.72 vs 11.83 ± 7.49, P , 0.05). Compared with lean subjects without parental diabetes, b cell function was lower by ;30% in lean subjects with parental diabetes, ;40% in obese subjects without parental diabetes, and ;50% in obese individuals with parental diabetes (P< 0.0001). African-Americans without parental diabetes had ;40%lower insulin sensitivity (P <0.001), twofold higher acute insulin secretion (P<0.001), but ;30% lower Disposition index (P , 0.01) compared with Caucasians without parental diabetes. Remarkably, there were no significant differences by ethnicity in these glucoregulatory measures among subjects with parental diabetes. Conclusion: Offspring with parental diabetes harbor substantial impairments in glucoregulation compared with individuals without parental diabetes. Ethnic disparities in glucoregulation were abrogated by parental diabetes.

Original languageEnglish (US)
Pages (from-to)514-522
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume103
Issue number2
DOIs
StatePublished - Feb 1 2018

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Medical problems
African Americans
Type 2 Diabetes Mellitus
Glucose Clamp Technique
Glucose Tolerance Test
Insulin Resistance
Body Mass Index
Prediabetic State
Glucose
Indirect Calorimetry
Anthropometry
Body Composition
Biochemistry
Physical Examination
Area Under Curve
Fasting
Cohort Studies
Fats
Insulin
Clamping devices

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

@article{6de2df95fe914e16a0e2026826367f40,
title = "Parental history of type 2 diabetes abrogates ethnic disparities in key glucoregulatory indices",
abstract = "Context: There are ethnic differences in glucoregulation and prevalence of type 2 diabetes, but studies on the role of genetics in modifying ethnic effects in normoglycemic African-Americans and Caucasians are limited. Therefore, we investigated glucoregulation in normoglycemic African- Americans and Caucasians with or without parental diabetes. Design: Fifty subjects with parental diabetes (from the Pathobiology of Prediabetes in a Biracial Cohort Study) and 50 subjects without parental diabetes were matched in age, sex, ethnicity, and body mass index (BMI). Subjects underwent a 75-g oral glucose tolerance test (OGTT), physical examination, anthropometry, biochemistries, indirect calorimetry and assessment of body composition, insulin sensitivity by euglycemic clamp (Si-clamp), and b-cell function by Disposition index. Results: The mean age was 40.5 ± 11.6 years, BMI 28.7 ± 5.9 kg/m2, fasting plasma glucose 90.2 ± 5.9 mg/dL, and 2-hour postglucose 120.0 ± 26.8 mg/dL. Offspring with parental diabetes showed higher glycemic excursion during OGTT-Area under the curve-glucose (16,005.6 ± 2324.7 vs 14,973.8 ± 1819.9, P< 0.005), lower Si-clamp (0.132 ± 0.068 vs 0.162 ± 0.081 mmol/kg fat-free mass/min/pmol/L, P< 0.05), and lower Disposition index (8.74 ± 5.72 vs 11.83 ± 7.49, P , 0.05). Compared with lean subjects without parental diabetes, b cell function was lower by ;30{\%} in lean subjects with parental diabetes, ;40{\%} in obese subjects without parental diabetes, and ;50{\%} in obese individuals with parental diabetes (P< 0.0001). African-Americans without parental diabetes had ;40{\%}lower insulin sensitivity (P <0.001), twofold higher acute insulin secretion (P<0.001), but ;30{\%} lower Disposition index (P , 0.01) compared with Caucasians without parental diabetes. Remarkably, there were no significant differences by ethnicity in these glucoregulatory measures among subjects with parental diabetes. Conclusion: Offspring with parental diabetes harbor substantial impairments in glucoregulation compared with individuals without parental diabetes. Ethnic disparities in glucoregulation were abrogated by parental diabetes.",
author = "Ebenezer Nyenwe and Ibiye Owei and Jim Wan and Samuel Dagogo-Jack",
year = "2018",
month = "2",
day = "1",
doi = "10.1210/jc.2017-01895",
language = "English (US)",
volume = "103",
pages = "514--522",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "2",

}

TY - JOUR

T1 - Parental history of type 2 diabetes abrogates ethnic disparities in key glucoregulatory indices

AU - Nyenwe, Ebenezer

AU - Owei, Ibiye

AU - Wan, Jim

AU - Dagogo-Jack, Samuel

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Context: There are ethnic differences in glucoregulation and prevalence of type 2 diabetes, but studies on the role of genetics in modifying ethnic effects in normoglycemic African-Americans and Caucasians are limited. Therefore, we investigated glucoregulation in normoglycemic African- Americans and Caucasians with or without parental diabetes. Design: Fifty subjects with parental diabetes (from the Pathobiology of Prediabetes in a Biracial Cohort Study) and 50 subjects without parental diabetes were matched in age, sex, ethnicity, and body mass index (BMI). Subjects underwent a 75-g oral glucose tolerance test (OGTT), physical examination, anthropometry, biochemistries, indirect calorimetry and assessment of body composition, insulin sensitivity by euglycemic clamp (Si-clamp), and b-cell function by Disposition index. Results: The mean age was 40.5 ± 11.6 years, BMI 28.7 ± 5.9 kg/m2, fasting plasma glucose 90.2 ± 5.9 mg/dL, and 2-hour postglucose 120.0 ± 26.8 mg/dL. Offspring with parental diabetes showed higher glycemic excursion during OGTT-Area under the curve-glucose (16,005.6 ± 2324.7 vs 14,973.8 ± 1819.9, P< 0.005), lower Si-clamp (0.132 ± 0.068 vs 0.162 ± 0.081 mmol/kg fat-free mass/min/pmol/L, P< 0.05), and lower Disposition index (8.74 ± 5.72 vs 11.83 ± 7.49, P , 0.05). Compared with lean subjects without parental diabetes, b cell function was lower by ;30% in lean subjects with parental diabetes, ;40% in obese subjects without parental diabetes, and ;50% in obese individuals with parental diabetes (P< 0.0001). African-Americans without parental diabetes had ;40%lower insulin sensitivity (P <0.001), twofold higher acute insulin secretion (P<0.001), but ;30% lower Disposition index (P , 0.01) compared with Caucasians without parental diabetes. Remarkably, there were no significant differences by ethnicity in these glucoregulatory measures among subjects with parental diabetes. Conclusion: Offspring with parental diabetes harbor substantial impairments in glucoregulation compared with individuals without parental diabetes. Ethnic disparities in glucoregulation were abrogated by parental diabetes.

AB - Context: There are ethnic differences in glucoregulation and prevalence of type 2 diabetes, but studies on the role of genetics in modifying ethnic effects in normoglycemic African-Americans and Caucasians are limited. Therefore, we investigated glucoregulation in normoglycemic African- Americans and Caucasians with or without parental diabetes. Design: Fifty subjects with parental diabetes (from the Pathobiology of Prediabetes in a Biracial Cohort Study) and 50 subjects without parental diabetes were matched in age, sex, ethnicity, and body mass index (BMI). Subjects underwent a 75-g oral glucose tolerance test (OGTT), physical examination, anthropometry, biochemistries, indirect calorimetry and assessment of body composition, insulin sensitivity by euglycemic clamp (Si-clamp), and b-cell function by Disposition index. Results: The mean age was 40.5 ± 11.6 years, BMI 28.7 ± 5.9 kg/m2, fasting plasma glucose 90.2 ± 5.9 mg/dL, and 2-hour postglucose 120.0 ± 26.8 mg/dL. Offspring with parental diabetes showed higher glycemic excursion during OGTT-Area under the curve-glucose (16,005.6 ± 2324.7 vs 14,973.8 ± 1819.9, P< 0.005), lower Si-clamp (0.132 ± 0.068 vs 0.162 ± 0.081 mmol/kg fat-free mass/min/pmol/L, P< 0.05), and lower Disposition index (8.74 ± 5.72 vs 11.83 ± 7.49, P , 0.05). Compared with lean subjects without parental diabetes, b cell function was lower by ;30% in lean subjects with parental diabetes, ;40% in obese subjects without parental diabetes, and ;50% in obese individuals with parental diabetes (P< 0.0001). African-Americans without parental diabetes had ;40%lower insulin sensitivity (P <0.001), twofold higher acute insulin secretion (P<0.001), but ;30% lower Disposition index (P , 0.01) compared with Caucasians without parental diabetes. Remarkably, there were no significant differences by ethnicity in these glucoregulatory measures among subjects with parental diabetes. Conclusion: Offspring with parental diabetes harbor substantial impairments in glucoregulation compared with individuals without parental diabetes. Ethnic disparities in glucoregulation were abrogated by parental diabetes.

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U2 - 10.1210/jc.2017-01895

DO - 10.1210/jc.2017-01895

M3 - Article

VL - 103

SP - 514

EP - 522

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 2

ER -