Parental reports on early language and motor milestones in fragile X syndrome with and without autism spectrum disorders

Rebecca Hinton, Dejan B. Budimirovic, Peter B. Marschik, Victor B. Talisa, Christa Einspieler, Tanjala Gipson, Michael V. Johnston

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: This study examined features of early language and motor milestones in children with fragile X syndrome (FXS) and contrasted these features with a diagnosis of Autism Spectrum Disorder (ASD) later in life in these children. Methods: We retrospectively examined parental report of age of onset for walking and first words for primarily boys with FXS, both with ASD (FXS±ASD) and FXS-only. The diagnosis of ASD was established by DSM-IV criteria, which were complemented by the ADOS. The age of onset was analyzed as a continuous and categorical variable, which were compared to the upper limit of typically developing children. Results: Individuals with FXS-only are more delayed in the onset of first words than first walks. The finding represents a pattern suggesting a continuum as robustly demonstrated in individuals with FXS±ASD vs. FXS-only. Conclusion: Our results support validity of FXS±ASD co-morbidity as a distinct phenotype in individuals with FXS.

Original languageEnglish (US)
Pages (from-to)58-66
Number of pages9
JournalDevelopmental Neurorehabilitation
Volume16
Issue number1
DOIs
StatePublished - Jan 1 2013

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Fragile X Syndrome
Language
Age of Onset
Reproducibility of Results
Diagnostic and Statistical Manual of Mental Disorders
Walking
Autism Spectrum Disorder
Parents
Morbidity
Phenotype

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Rehabilitation
  • Developmental Neuroscience

Cite this

Parental reports on early language and motor milestones in fragile X syndrome with and without autism spectrum disorders. / Hinton, Rebecca; Budimirovic, Dejan B.; Marschik, Peter B.; Talisa, Victor B.; Einspieler, Christa; Gipson, Tanjala; Johnston, Michael V.

In: Developmental Neurorehabilitation, Vol. 16, No. 1, 01.01.2013, p. 58-66.

Research output: Contribution to journalArticle

Hinton, Rebecca ; Budimirovic, Dejan B. ; Marschik, Peter B. ; Talisa, Victor B. ; Einspieler, Christa ; Gipson, Tanjala ; Johnston, Michael V. / Parental reports on early language and motor milestones in fragile X syndrome with and without autism spectrum disorders. In: Developmental Neurorehabilitation. 2013 ; Vol. 16, No. 1. pp. 58-66.
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