Passive Transfer of Arthritis to Mice by Injection of Human Anti-Type II Collagen Antibody

PAUL H. WOOLEY, HARVINDER S. LUTHRA, SUJAY K. SINGH, ANGELA R. HUSE, John Stuart, CHELLA S. DAVID

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Abstract

The serum IgG fraction from a patient with seronegative rheumatoid-like arthritis which contained a high anti-type II collagen antibody titer was injected intravenously into mice susceptible to type II collagen-induced arthritis. A mild, transient, inflammatory arthritis was observed in 20 to 25% of the animals, whereas histologic signs of disease were evident in most of the injected mice. Purified human anti-type II collagen immunoglobulin injected into the knee joints of mice was also shown to induce a transient, inflammatory arthritis. Radiolabeled human anti-type II collagen IgG was shown to accumulate in the peripheral joints of mice, and the specificity of the antibody was shown to be similar to the specificity of anticollagen antibody eluted from the joints of mice with collagen-induced arthritis.

Original languageEnglish (US)
Pages (from-to)737-743
Number of pages7
JournalMayo Clinic Proceedings
Volume59
Issue number11-12
DOIs
StatePublished - Jan 1 1984

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Collagen Type II
Arthritis
Injections
Antibodies
Experimental Arthritis
Antibody Specificity
Immunoglobulin G
Joints
Knee Joint
Immunoglobulins
Rheumatoid Arthritis
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

WOOLEY, PAUL. H., LUTHRA, HARVINDER. S., SINGH, SUJAY. K., HUSE, ANGELA. R., Stuart, J., & DAVID, CHELLA. S. (1984). Passive Transfer of Arthritis to Mice by Injection of Human Anti-Type II Collagen Antibody. Mayo Clinic Proceedings, 59(11-12), 737-743. https://doi.org/10.1016/S0025-6196(12)65583-9

Passive Transfer of Arthritis to Mice by Injection of Human Anti-Type II Collagen Antibody. / WOOLEY, PAUL H.; LUTHRA, HARVINDER S.; SINGH, SUJAY K.; HUSE, ANGELA R.; Stuart, John; DAVID, CHELLA S.

In: Mayo Clinic Proceedings, Vol. 59, No. 11-12, 01.01.1984, p. 737-743.

Research output: Contribution to journalArticle

WOOLEY, PAULH, LUTHRA, HARVINDERS, SINGH, SUJAYK, HUSE, ANGELAR, Stuart, J & DAVID, CHELLAS 1984, 'Passive Transfer of Arthritis to Mice by Injection of Human Anti-Type II Collagen Antibody', Mayo Clinic Proceedings, vol. 59, no. 11-12, pp. 737-743. https://doi.org/10.1016/S0025-6196(12)65583-9
WOOLEY PAULH, LUTHRA HARVINDERS, SINGH SUJAYK, HUSE ANGELAR, Stuart J, DAVID CHELLAS. Passive Transfer of Arthritis to Mice by Injection of Human Anti-Type II Collagen Antibody. Mayo Clinic Proceedings. 1984 Jan 1;59(11-12):737-743. https://doi.org/10.1016/S0025-6196(12)65583-9
WOOLEY, PAUL H. ; LUTHRA, HARVINDER S. ; SINGH, SUJAY K. ; HUSE, ANGELA R. ; Stuart, John ; DAVID, CHELLA S. / Passive Transfer of Arthritis to Mice by Injection of Human Anti-Type II Collagen Antibody. In: Mayo Clinic Proceedings. 1984 ; Vol. 59, No. 11-12. pp. 737-743.
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