Passive transfer of resistance to frambesial infection in hamsters

R. F. Schell, J. L. Le Frock, Jegdish Babu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The immune mechanism by which hamsters acquire resistance to infection with Treponema pertenue, the causative agent of frambesia, or yaws, has not been elucidated. Serum or cells (spleen or lymph node) obtained from hamsters resistant to frambesial infection were transferred to normal syngenic recipients, who were subsequently infected with T. pertenue. The following parameters were used to measure the ability of immune serum or cells to confer resistance on recipient hamsters to frambesial infection: inhibition of the development of cutaneous lesions, decreased weight, and number of treponemes in the inguinal lymph nodes. This investigation demonstrated that immune serum conferred protection on recipient hamsters infected with T. pertenue. Discontinuation of the administration of immune serum (18 days after frambesial infection) did not result in the development of cutaneous lesions. Since the inguinal lymph nodes contained a sizeable number of treponemes (2.6 x 10 5), immune serum failed to prevent frambesial infection. Recipients of immune spleen or lymph node cells initially developed frambesial lesions 9 days after infection. The frambesial lesions began to resolve 12 to 14 days after infection and by day 21 had completely regressed. These results illustrated that humoral factors and cells are involved in resistance of the hamster to frambesial infection.

Original languageEnglish (US)
Pages (from-to)430-435
Number of pages6
JournalInfection and Immunity
Volume21
Issue number2
StatePublished - 1978
Externally publishedYes

Fingerprint

Cricetinae
Infection
Immune Sera
Lymph Nodes
Yaws
Groin
Spleen
Treponema
Skin
Weights and Measures
Serum

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Passive transfer of resistance to frambesial infection in hamsters. / Schell, R. F.; Le Frock, J. L.; Babu, Jegdish.

In: Infection and Immunity, Vol. 21, No. 2, 1978, p. 430-435.

Research output: Contribution to journalArticle

Schell, R. F. ; Le Frock, J. L. ; Babu, Jegdish. / Passive transfer of resistance to frambesial infection in hamsters. In: Infection and Immunity. 1978 ; Vol. 21, No. 2. pp. 430-435.
@article{144fba91645b46088da18acf0f07bb57,
title = "Passive transfer of resistance to frambesial infection in hamsters",
abstract = "The immune mechanism by which hamsters acquire resistance to infection with Treponema pertenue, the causative agent of frambesia, or yaws, has not been elucidated. Serum or cells (spleen or lymph node) obtained from hamsters resistant to frambesial infection were transferred to normal syngenic recipients, who were subsequently infected with T. pertenue. The following parameters were used to measure the ability of immune serum or cells to confer resistance on recipient hamsters to frambesial infection: inhibition of the development of cutaneous lesions, decreased weight, and number of treponemes in the inguinal lymph nodes. This investigation demonstrated that immune serum conferred protection on recipient hamsters infected with T. pertenue. Discontinuation of the administration of immune serum (18 days after frambesial infection) did not result in the development of cutaneous lesions. Since the inguinal lymph nodes contained a sizeable number of treponemes (2.6 x 10 5), immune serum failed to prevent frambesial infection. Recipients of immune spleen or lymph node cells initially developed frambesial lesions 9 days after infection. The frambesial lesions began to resolve 12 to 14 days after infection and by day 21 had completely regressed. These results illustrated that humoral factors and cells are involved in resistance of the hamster to frambesial infection.",
author = "Schell, {R. F.} and {Le Frock}, {J. L.} and Jegdish Babu",
year = "1978",
language = "English (US)",
volume = "21",
pages = "430--435",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "2",

}

TY - JOUR

T1 - Passive transfer of resistance to frambesial infection in hamsters

AU - Schell, R. F.

AU - Le Frock, J. L.

AU - Babu, Jegdish

PY - 1978

Y1 - 1978

N2 - The immune mechanism by which hamsters acquire resistance to infection with Treponema pertenue, the causative agent of frambesia, or yaws, has not been elucidated. Serum or cells (spleen or lymph node) obtained from hamsters resistant to frambesial infection were transferred to normal syngenic recipients, who were subsequently infected with T. pertenue. The following parameters were used to measure the ability of immune serum or cells to confer resistance on recipient hamsters to frambesial infection: inhibition of the development of cutaneous lesions, decreased weight, and number of treponemes in the inguinal lymph nodes. This investigation demonstrated that immune serum conferred protection on recipient hamsters infected with T. pertenue. Discontinuation of the administration of immune serum (18 days after frambesial infection) did not result in the development of cutaneous lesions. Since the inguinal lymph nodes contained a sizeable number of treponemes (2.6 x 10 5), immune serum failed to prevent frambesial infection. Recipients of immune spleen or lymph node cells initially developed frambesial lesions 9 days after infection. The frambesial lesions began to resolve 12 to 14 days after infection and by day 21 had completely regressed. These results illustrated that humoral factors and cells are involved in resistance of the hamster to frambesial infection.

AB - The immune mechanism by which hamsters acquire resistance to infection with Treponema pertenue, the causative agent of frambesia, or yaws, has not been elucidated. Serum or cells (spleen or lymph node) obtained from hamsters resistant to frambesial infection were transferred to normal syngenic recipients, who were subsequently infected with T. pertenue. The following parameters were used to measure the ability of immune serum or cells to confer resistance on recipient hamsters to frambesial infection: inhibition of the development of cutaneous lesions, decreased weight, and number of treponemes in the inguinal lymph nodes. This investigation demonstrated that immune serum conferred protection on recipient hamsters infected with T. pertenue. Discontinuation of the administration of immune serum (18 days after frambesial infection) did not result in the development of cutaneous lesions. Since the inguinal lymph nodes contained a sizeable number of treponemes (2.6 x 10 5), immune serum failed to prevent frambesial infection. Recipients of immune spleen or lymph node cells initially developed frambesial lesions 9 days after infection. The frambesial lesions began to resolve 12 to 14 days after infection and by day 21 had completely regressed. These results illustrated that humoral factors and cells are involved in resistance of the hamster to frambesial infection.

UR - http://www.scopus.com/inward/record.url?scp=0018095579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018095579&partnerID=8YFLogxK

M3 - Article

VL - 21

SP - 430

EP - 435

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 2

ER -