Patent foramen ovale: Assessment, clinical significance and therapeutic options

Farhan Aslam, Jamshid Shirani, Attiya Anwar Haque

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Foramen ovale plays an important function in the fetus but is of no physiologic significance after birth and closes in most individuals. In about one fourth of the population, however, foramen ovale remains open for life and has been associated with cerebrovascular accidents, especially in younger patients, presumably through paradoxical embolism. Patent foramen ovale (PFO) has also been associated with hypoxia, migraine headaches and neurologic findings of decompression illness in scuba divers. Availability of transesophageal echocardiography and its frequent use in the management of patients with stroke has lead to frequent detection of PFO. In addition, the recent development of devices and techniques for percutaneous closure of PFO has resulted in widespread enthusiasm for such interventions, even when a clear etiologic role for PFO may not be established. In the United States, the Federal Drug Administration (FDA) has approved two such devices through compassionate investigational device exemption without adequate data from large randomized clinical studies. Other such devices are undergoing evaluation in clinical trials. Expert opinions have been helpful for clinical decision making in management of patients with PFO associated with stroke, hypoxia, decompression sickness and migraine headaches.

Original languageEnglish (US)
Pages (from-to)1367-1372
Number of pages6
JournalSouthern medical journal
Volume99
Issue number12
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

Fingerprint

Patent Foramen Ovale
Foramen Ovale
Equipment and Supplies
Stroke
Migraine Disorders
Paradoxical Embolism
Therapeutics
Decompression Sickness
Transesophageal Echocardiography
Expert Testimony
Neurologic Manifestations
Decompression
Fetus
Clinical Trials
Parturition
Pharmaceutical Preparations
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Patent foramen ovale : Assessment, clinical significance and therapeutic options. / Aslam, Farhan; Shirani, Jamshid; Haque, Attiya Anwar.

In: Southern medical journal, Vol. 99, No. 12, 01.12.2006, p. 1367-1372.

Research output: Contribution to journalReview article

Aslam, Farhan ; Shirani, Jamshid ; Haque, Attiya Anwar. / Patent foramen ovale : Assessment, clinical significance and therapeutic options. In: Southern medical journal. 2006 ; Vol. 99, No. 12. pp. 1367-1372.
@article{1c29f71838c149f6bb7ee609d131a369,
title = "Patent foramen ovale: Assessment, clinical significance and therapeutic options",
abstract = "Foramen ovale plays an important function in the fetus but is of no physiologic significance after birth and closes in most individuals. In about one fourth of the population, however, foramen ovale remains open for life and has been associated with cerebrovascular accidents, especially in younger patients, presumably through paradoxical embolism. Patent foramen ovale (PFO) has also been associated with hypoxia, migraine headaches and neurologic findings of decompression illness in scuba divers. Availability of transesophageal echocardiography and its frequent use in the management of patients with stroke has lead to frequent detection of PFO. In addition, the recent development of devices and techniques for percutaneous closure of PFO has resulted in widespread enthusiasm for such interventions, even when a clear etiologic role for PFO may not be established. In the United States, the Federal Drug Administration (FDA) has approved two such devices through compassionate investigational device exemption without adequate data from large randomized clinical studies. Other such devices are undergoing evaluation in clinical trials. Expert opinions have been helpful for clinical decision making in management of patients with PFO associated with stroke, hypoxia, decompression sickness and migraine headaches.",
author = "Farhan Aslam and Jamshid Shirani and Haque, {Attiya Anwar}",
year = "2006",
month = "12",
day = "1",
doi = "10.1097/01.smj.0000251839.59000.47",
language = "English (US)",
volume = "99",
pages = "1367--1372",
journal = "Southern Medical Journal",
issn = "0038-4348",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - Patent foramen ovale

T2 - Assessment, clinical significance and therapeutic options

AU - Aslam, Farhan

AU - Shirani, Jamshid

AU - Haque, Attiya Anwar

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Foramen ovale plays an important function in the fetus but is of no physiologic significance after birth and closes in most individuals. In about one fourth of the population, however, foramen ovale remains open for life and has been associated with cerebrovascular accidents, especially in younger patients, presumably through paradoxical embolism. Patent foramen ovale (PFO) has also been associated with hypoxia, migraine headaches and neurologic findings of decompression illness in scuba divers. Availability of transesophageal echocardiography and its frequent use in the management of patients with stroke has lead to frequent detection of PFO. In addition, the recent development of devices and techniques for percutaneous closure of PFO has resulted in widespread enthusiasm for such interventions, even when a clear etiologic role for PFO may not be established. In the United States, the Federal Drug Administration (FDA) has approved two such devices through compassionate investigational device exemption without adequate data from large randomized clinical studies. Other such devices are undergoing evaluation in clinical trials. Expert opinions have been helpful for clinical decision making in management of patients with PFO associated with stroke, hypoxia, decompression sickness and migraine headaches.

AB - Foramen ovale plays an important function in the fetus but is of no physiologic significance after birth and closes in most individuals. In about one fourth of the population, however, foramen ovale remains open for life and has been associated with cerebrovascular accidents, especially in younger patients, presumably through paradoxical embolism. Patent foramen ovale (PFO) has also been associated with hypoxia, migraine headaches and neurologic findings of decompression illness in scuba divers. Availability of transesophageal echocardiography and its frequent use in the management of patients with stroke has lead to frequent detection of PFO. In addition, the recent development of devices and techniques for percutaneous closure of PFO has resulted in widespread enthusiasm for such interventions, even when a clear etiologic role for PFO may not be established. In the United States, the Federal Drug Administration (FDA) has approved two such devices through compassionate investigational device exemption without adequate data from large randomized clinical studies. Other such devices are undergoing evaluation in clinical trials. Expert opinions have been helpful for clinical decision making in management of patients with PFO associated with stroke, hypoxia, decompression sickness and migraine headaches.

UR - http://www.scopus.com/inward/record.url?scp=33845952302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845952302&partnerID=8YFLogxK

U2 - 10.1097/01.smj.0000251839.59000.47

DO - 10.1097/01.smj.0000251839.59000.47

M3 - Review article

C2 - 17233193

AN - SCOPUS:33845952302

VL - 99

SP - 1367

EP - 1372

JO - Southern Medical Journal

JF - Southern Medical Journal

SN - 0038-4348

IS - 12

ER -