Pathogenic significance of P-fimbriated Escherichia coli in urinary tract infections

G. J. Domingue, J. A. Roberts, Rodolfo Laucirica, M. H. Ratner, D. P. Bell, G. M. Suarez, G. Kallenius, S. Svenson

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Abstract

The over-all aim of this study was to determine the pathogenic significance, and bacteriological and serological characteristics of P-fimbriated organisms isolated from a general population of patients with bacteriuria. A P-receptor specific particle agglutination test was used to identify P-fimbriated bacteria among 2,010 isolates from male and female patients with bacteriuria (age range infancy to 91 years). Of the 2,010 isolates 206 (10.2 per cent) were positive for P-fimbriae by the P-receptor specific particle agglutination test. Only Escherichia coli was found to be P-fimbriated, with an incidence of 21.5 per cent among 956 Escherichia coli isolates. The critical characteristic of pyelonephritic strains of Escherichia coli was P-fimbriation. In cases of nonobstructive acute pyelonephritis 100 per cent of the infecting bacteria were P-fimbriated. The data indicated clearly that the serotype, biotype, presence of type 1 fimbriae (mannose sensitive), undefined mannoseresistant adhesions, hemolysin production and motility of P-fimbriated Escherichia coli were clinically unimportant differential strain characteristics and not indicative of the virulence of P-fimbriated Escherichia coli within clinical syndromes. Isogenic P-fimbriated Escherichia coli strains were isolated from noncompromised patients in all clinical categories, that is pyelonephritis, asymptomatic bacteriuria and cystitis. A variety of bacterial strains appears to be capable of causing acute pyelonephritis in the presence of obstructive uropathic conditions, regardless of P-fimbriation. Therefore, P-fimbriation becomes a noncritical factor in compromised patients. The P-receptor specific particle agglutination test is a simple and rapid method to determine whether bacteria are P-fimbriated and may be an important screening method to identify those bacteria isolated from individuals at risk for nonobstructive acute pyelonephritis.

Original languageEnglish (US)
Pages (from-to)983-988
Number of pages6
JournalJournal of Urology
Volume133
Issue number6
StatePublished - Jan 1 1985

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Urinary Tract Infections
Pyelonephritis
Escherichia coli
Bacteriuria
Agglutination Tests
Bacteria
Hemolysin Proteins
Cystitis
Mannose
Virulence
Incidence
Population

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Domingue, G. J., Roberts, J. A., Laucirica, R., Ratner, M. H., Bell, D. P., Suarez, G. M., ... Svenson, S. (1985). Pathogenic significance of P-fimbriated Escherichia coli in urinary tract infections. Journal of Urology, 133(6), 983-988.

Pathogenic significance of P-fimbriated Escherichia coli in urinary tract infections. / Domingue, G. J.; Roberts, J. A.; Laucirica, Rodolfo; Ratner, M. H.; Bell, D. P.; Suarez, G. M.; Kallenius, G.; Svenson, S.

In: Journal of Urology, Vol. 133, No. 6, 01.01.1985, p. 983-988.

Research output: Contribution to journalArticle

Domingue, GJ, Roberts, JA, Laucirica, R, Ratner, MH, Bell, DP, Suarez, GM, Kallenius, G & Svenson, S 1985, 'Pathogenic significance of P-fimbriated Escherichia coli in urinary tract infections', Journal of Urology, vol. 133, no. 6, pp. 983-988.
Domingue GJ, Roberts JA, Laucirica R, Ratner MH, Bell DP, Suarez GM et al. Pathogenic significance of P-fimbriated Escherichia coli in urinary tract infections. Journal of Urology. 1985 Jan 1;133(6):983-988.
Domingue, G. J. ; Roberts, J. A. ; Laucirica, Rodolfo ; Ratner, M. H. ; Bell, D. P. ; Suarez, G. M. ; Kallenius, G. ; Svenson, S. / Pathogenic significance of P-fimbriated Escherichia coli in urinary tract infections. In: Journal of Urology. 1985 ; Vol. 133, No. 6. pp. 983-988.
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