Patterns of cerebral glucose utilization in depression, multiple infarct dementia, and Alzheimer's disease.

D. E. Kuhl, E. Metter, W. H. Riege

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Abstract

Patterns of local cerebral glucose utilization were determined in moderately to severely disabled patients with D (N = 7), MID (N = 6), and AD (N = 6), and in normal controls (N = 6), using positron emission tomography with the 18F-fluorodeoxyglucose method. Average global metabolic rate was decreased 30% in patients with AD, but overlap among the other groups reduced the discriminant value of this measure. In depressed patients, the cerebral metabolic pattern was normal, except for evidence of hypometabolic zone in the posterior-inferior frontal cortex which was of marginal statistical significance. In MID, focal metabolic defects were scattered throughout the brain and exceeded the extent of infarction. In AD, metabolism was markedly reduced in cortex, especially parietal cortex, but relatively preserved in caudate, thalamus, anterior cingulate gyrus, pre- and post-central gyrus, and calcarine occipital cortex, a pattern duplicating the degree and location of pathological and neurochemical alterations characteristic of this disorder.

Original languageEnglish (US)
Pages (from-to)211-226
Number of pages16
JournalResearch publications - Association for Research in Nervous and Mental Disease
Volume63
StatePublished - Jan 1 1985

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Dementia
Alzheimer Disease
Depression
Glucose
Occipital Lobe
Parietal Lobe
Somatosensory Cortex
Gyrus Cinguli
Fluorodeoxyglucose F18
Frontal Lobe
Thalamus
Positron-Emission Tomography
Infarction
Brain
cloricromen

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "Patterns of local cerebral glucose utilization were determined in moderately to severely disabled patients with D (N = 7), MID (N = 6), and AD (N = 6), and in normal controls (N = 6), using positron emission tomography with the 18F-fluorodeoxyglucose method. Average global metabolic rate was decreased 30{\%} in patients with AD, but overlap among the other groups reduced the discriminant value of this measure. In depressed patients, the cerebral metabolic pattern was normal, except for evidence of hypometabolic zone in the posterior-inferior frontal cortex which was of marginal statistical significance. In MID, focal metabolic defects were scattered throughout the brain and exceeded the extent of infarction. In AD, metabolism was markedly reduced in cortex, especially parietal cortex, but relatively preserved in caudate, thalamus, anterior cingulate gyrus, pre- and post-central gyrus, and calcarine occipital cortex, a pattern duplicating the degree and location of pathological and neurochemical alterations characteristic of this disorder.",
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AU - Metter, E.

AU - Riege, W. H.

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N2 - Patterns of local cerebral glucose utilization were determined in moderately to severely disabled patients with D (N = 7), MID (N = 6), and AD (N = 6), and in normal controls (N = 6), using positron emission tomography with the 18F-fluorodeoxyglucose method. Average global metabolic rate was decreased 30% in patients with AD, but overlap among the other groups reduced the discriminant value of this measure. In depressed patients, the cerebral metabolic pattern was normal, except for evidence of hypometabolic zone in the posterior-inferior frontal cortex which was of marginal statistical significance. In MID, focal metabolic defects were scattered throughout the brain and exceeded the extent of infarction. In AD, metabolism was markedly reduced in cortex, especially parietal cortex, but relatively preserved in caudate, thalamus, anterior cingulate gyrus, pre- and post-central gyrus, and calcarine occipital cortex, a pattern duplicating the degree and location of pathological and neurochemical alterations characteristic of this disorder.

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