Patterns of weight change associated with long-term weight change and cardiovascular disease risk factors in the look AHEAD study

Rebecca H. Neiberg, Rena R. Wing, George A. Bray, David M. Reboussin, Amy D. Rickman, Karen Johnson, Abbas E. Kitabchi, Lucy F. Faulconbridge, Dalane W. Kitzman, Mark A. Espeland

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

This article provides an assessment of the associations that weight-loss patterns during the first year of an intensive lifestyle intervention have with 4-year maintenance and health outcomes. Two components described patterns of weight change during the first year of intervention: one reflected the typical pattern of weight loss over the 12 months, but distinguished those who lost larger amounts across the monthly intervals from those who lost less. The second component reflected the weight change trajectory, and distinguished a pattern of initial weight loss followed by regain vs. a more sustained pattern of weight loss. Two thousand four hundred and thirty eight individuals aged 45-76 years with type 2 diabetes mellitus, who enrolled in the weight-loss intervention of a randomized clinical trial, were assigned scores according to how their weight losses reflected these patterns. Relationships these scores had with weight losses and health outcomes (glycosolated hemoglobinhemoglobin A1c (HbA1c); systolic blood pressure, high-density lipoprotein (HDL)-cholesterol, and triglycerides) over 4 years were described. When compared to those with lower scores on the two components, both individuals who had larger month-to-month weight losses in year 1 and whose weight loss was more sustained during the first year had better maintenance of weight loss over 4 years, independent of characteristics traditionally linked to weight loss success (P < 0.001). While relationships with year 4 weight loss were stronger, the pattern of larger monthly weight loss during year 1 was also independently predictive of year 4 levels of HbA1c, HDL-cholesterol, and systolic blood pressure.

Original languageEnglish (US)
Pages (from-to)2048-2056
Number of pages9
JournalObesity
Volume20
Issue number10
DOIs
StatePublished - Oct 1 2012

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Weight Loss
Cardiovascular Diseases
Weights and Measures
Blood Pressure
HDL Cholesterol
Maintenance
Health
Type 2 Diabetes Mellitus
Life Style
Randomized Controlled Trials

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Neiberg, R. H., Wing, R. R., Bray, G. A., Reboussin, D. M., Rickman, A. D., Johnson, K., ... Espeland, M. A. (2012). Patterns of weight change associated with long-term weight change and cardiovascular disease risk factors in the look AHEAD study. Obesity, 20(10), 2048-2056. https://doi.org/10.1038/oby.2012.33

Patterns of weight change associated with long-term weight change and cardiovascular disease risk factors in the look AHEAD study. / Neiberg, Rebecca H.; Wing, Rena R.; Bray, George A.; Reboussin, David M.; Rickman, Amy D.; Johnson, Karen; Kitabchi, Abbas E.; Faulconbridge, Lucy F.; Kitzman, Dalane W.; Espeland, Mark A.

In: Obesity, Vol. 20, No. 10, 01.10.2012, p. 2048-2056.

Research output: Contribution to journalArticle

Neiberg, RH, Wing, RR, Bray, GA, Reboussin, DM, Rickman, AD, Johnson, K, Kitabchi, AE, Faulconbridge, LF, Kitzman, DW & Espeland, MA 2012, 'Patterns of weight change associated with long-term weight change and cardiovascular disease risk factors in the look AHEAD study', Obesity, vol. 20, no. 10, pp. 2048-2056. https://doi.org/10.1038/oby.2012.33
Neiberg, Rebecca H. ; Wing, Rena R. ; Bray, George A. ; Reboussin, David M. ; Rickman, Amy D. ; Johnson, Karen ; Kitabchi, Abbas E. ; Faulconbridge, Lucy F. ; Kitzman, Dalane W. ; Espeland, Mark A. / Patterns of weight change associated with long-term weight change and cardiovascular disease risk factors in the look AHEAD study. In: Obesity. 2012 ; Vol. 20, No. 10. pp. 2048-2056.
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